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Role of viral ribonucleoproteins in human papillomavirus type 16 gene expression

Kajitani, Naoko LU and Schwartz, Stefan LU (2020) In Viruses 12(10).
Abstract

Human papillomaviruses (HPVs) depend on the cellular RNA-processing machineries including alternative RNA splicing and polyadenylation to coordinate HPV gene expression. HPV RNA processing is controlled by cis-regulatory RNA elements and trans-regulatory factors since the HPV splice sites are suboptimal. The definition of HPV exons and introns may differ between individual HPV mRNA species and is complicated by the fact that many HPV protein-coding sequences overlap. The formation of HPV ribonucleoproteins consisting of HPV pre-mRNAs and multiple cellular RNA-binding proteins may result in the different outcomes of HPV gene expression, which contributes to the HPV life cycle progression and HPV-associated cancer development. In this... (More)

Human papillomaviruses (HPVs) depend on the cellular RNA-processing machineries including alternative RNA splicing and polyadenylation to coordinate HPV gene expression. HPV RNA processing is controlled by cis-regulatory RNA elements and trans-regulatory factors since the HPV splice sites are suboptimal. The definition of HPV exons and introns may differ between individual HPV mRNA species and is complicated by the fact that many HPV protein-coding sequences overlap. The formation of HPV ribonucleoproteins consisting of HPV pre-mRNAs and multiple cellular RNA-binding proteins may result in the different outcomes of HPV gene expression, which contributes to the HPV life cycle progression and HPV-associated cancer development. In this review, we summarize the regulation of HPV16 gene expression at the level of RNA processing with focus on the interactions between HPV16 pre-mRNAs and cellular RNA-binding factors.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HnRNP, Human papillomavirus (HPV), Papillomavirus, Polyadenylation, Splicing, SR proteins
in
Viruses
volume
12
issue
10
article number
1110
publisher
MDPI AG
external identifiers
  • scopus:85092320962
  • pmid:33007936
ISSN
1999-4915
DOI
10.3390/v12101110
language
English
LU publication?
yes
id
190594aa-c0d0-4d39-89dc-54fbc732686d
date added to LUP
2020-11-06 08:27:09
date last changed
2024-06-14 02:58:56
@article{190594aa-c0d0-4d39-89dc-54fbc732686d,
  abstract     = {{<p>Human papillomaviruses (HPVs) depend on the cellular RNA-processing machineries including alternative RNA splicing and polyadenylation to coordinate HPV gene expression. HPV RNA processing is controlled by cis-regulatory RNA elements and trans-regulatory factors since the HPV splice sites are suboptimal. The definition of HPV exons and introns may differ between individual HPV mRNA species and is complicated by the fact that many HPV protein-coding sequences overlap. The formation of HPV ribonucleoproteins consisting of HPV pre-mRNAs and multiple cellular RNA-binding proteins may result in the different outcomes of HPV gene expression, which contributes to the HPV life cycle progression and HPV-associated cancer development. In this review, we summarize the regulation of HPV16 gene expression at the level of RNA processing with focus on the interactions between HPV16 pre-mRNAs and cellular RNA-binding factors.</p>}},
  author       = {{Kajitani, Naoko and Schwartz, Stefan}},
  issn         = {{1999-4915}},
  keywords     = {{HnRNP; Human papillomavirus (HPV); Papillomavirus; Polyadenylation; Splicing; SR proteins}},
  language     = {{eng}},
  number       = {{10}},
  publisher    = {{MDPI AG}},
  series       = {{Viruses}},
  title        = {{Role of viral ribonucleoproteins in human papillomavirus type 16 gene expression}},
  url          = {{http://dx.doi.org/10.3390/v12101110}},
  doi          = {{10.3390/v12101110}},
  volume       = {{12}},
  year         = {{2020}},
}