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Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation

Wirestam, Ronnie LU orcid ; Engvall, Christian ; Ryding, Erik ; Holtas, Stig ; Stahlberg, Freddy and Reinstrup, Peter (2009) 3rd International Conference on Bioinformatics and Biomedical Engineering p.2291-2294
Abstract
Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously... (More)
Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously published DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied. (Less)
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author
; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
magnetic resonance imaging, perfusion, cerebral blood flow, mean, transit time, hypocapnia
host publication
2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11
pages
2291 - 2294
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
conference name
3rd International Conference on Bioinformatics and Biomedical Engineering
conference dates
2009-06-11 - 2009-06-16
external identifiers
  • wos:000286342801119
  • scopus:72749090604
language
English
LU publication?
yes
id
7f3c1aa7-1a65-4698-9146-6acba2c16b18 (old id 1917519)
date added to LUP
2016-04-04 12:04:05
date last changed
2021-06-16 02:21:39
@inproceedings{7f3c1aa7-1a65-4698-9146-6acba2c16b18,
  abstract     = {Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously published DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.},
  author       = {Wirestam, Ronnie and Engvall, Christian and Ryding, Erik and Holtas, Stig and Stahlberg, Freddy and Reinstrup, Peter},
  booktitle    = {2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11},
  language     = {eng},
  pages        = {2291--2294},
  publisher    = {IEEE - Institute of Electrical and Electronics Engineers Inc.},
  title        = {Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation},
  year         = {2009},
}