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Older Men With Low Serum IGF-1 Have an Increased Risk of Incident Fractures: The MrOS Sweden Study

Ohlsson, Claes; Mellstrom, Dan; Carlzon, Daniel; Orwoll, Eric; Ljunggren, Osten; Karlsson, Magnus LU and Vandenput, Liesbeth (2011) In Journal of Bone and Mineral Research 26(4). p.865-872
Abstract
Osteoporosis-related fractures constitute a major health concern not only in women but also in men. Insulin-like growth factor 1 (IGF-1) is a key determinant of bone mass, but the association between serum IGF-1 and incident fractures in men remains unclear. To determine the predictive value of serum IGF-1 for fracture risk in men, older men (n = 2902, mean age of 75 years) participating in the prospective, population-based Osteoporotic Fractures in Men (MrOS) Sweden study were followed for a mean of 3.3 years. Serum IGF-1 was measured at baseline by radioimmunoassay. Fractures occurring after the baseline visit were validated. In age-adjusted hazards regression analyses, serum IGF-1 associated inversely with risk of all fractures [hazard... (More)
Osteoporosis-related fractures constitute a major health concern not only in women but also in men. Insulin-like growth factor 1 (IGF-1) is a key determinant of bone mass, but the association between serum IGF-1 and incident fractures in men remains unclear. To determine the predictive value of serum IGF-1 for fracture risk in men, older men (n = 2902, mean age of 75 years) participating in the prospective, population-based Osteoporotic Fractures in Men (MrOS) Sweden study were followed for a mean of 3.3 years. Serum IGF-1 was measured at baseline by radioimmunoassay. Fractures occurring after the baseline visit were validated. In age-adjusted hazards regression analyses, serum IGF-1 associated inversely with risk of all fractures [hazard ratio (HR) per SD decrease = 1.23, 95% confidence interval (CI) 1.07-1.41], hip fractures (HR per SD decrease = 1.45, 95% CI 1.07-1.97), and clinical vertebral fractures (HR per SD decrease = 1.40, 95% CI 1.10-1-78). The predictive role of serum IGF-1 for fracture risk was unaffected by adjustment for height, weight, prevalent fractures, falls, and major prevalent diseases. Further adjustment for bone mineral density (BMD) resulted in an attenuated but still significant association between serum IGF-1 and fracture risk. Serum IGF-1 below but not above the median was inversely related to fracture incidence. The population-attributable risk proportion was 7.5% for all fractures and 22.9% for hip fractures. Taken together, older men with low serum IGF-1 have an increased fracture risk, especially for the two most important fracture types, hip and vertebral fractures. The association between serum IGF-1 and fracture risk is partly mediated via BMD. (C) 2011 American Society for Bone and Mineral Research. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
POPULATION STUDIES, INSULIN-LIKE GROWTH FACTOR 1, AGING, MEN, FRACTURE
in
Journal of Bone and Mineral Research
volume
26
issue
4
pages
865 - 872
publisher
AMBMR
external identifiers
  • wos:000288861400021
  • scopus:79953031666
ISSN
1523-4681
DOI
10.1002/jbmr.281
language
English
LU publication?
yes
id
dd9aee36-322f-48f3-8f14-3212c5852e87 (old id 1925293)
date added to LUP
2011-05-02 09:56:10
date last changed
2017-11-05 03:05:38
@article{dd9aee36-322f-48f3-8f14-3212c5852e87,
  abstract     = {Osteoporosis-related fractures constitute a major health concern not only in women but also in men. Insulin-like growth factor 1 (IGF-1) is a key determinant of bone mass, but the association between serum IGF-1 and incident fractures in men remains unclear. To determine the predictive value of serum IGF-1 for fracture risk in men, older men (n = 2902, mean age of 75 years) participating in the prospective, population-based Osteoporotic Fractures in Men (MrOS) Sweden study were followed for a mean of 3.3 years. Serum IGF-1 was measured at baseline by radioimmunoassay. Fractures occurring after the baseline visit were validated. In age-adjusted hazards regression analyses, serum IGF-1 associated inversely with risk of all fractures [hazard ratio (HR) per SD decrease = 1.23, 95% confidence interval (CI) 1.07-1.41], hip fractures (HR per SD decrease = 1.45, 95% CI 1.07-1.97), and clinical vertebral fractures (HR per SD decrease = 1.40, 95% CI 1.10-1-78). The predictive role of serum IGF-1 for fracture risk was unaffected by adjustment for height, weight, prevalent fractures, falls, and major prevalent diseases. Further adjustment for bone mineral density (BMD) resulted in an attenuated but still significant association between serum IGF-1 and fracture risk. Serum IGF-1 below but not above the median was inversely related to fracture incidence. The population-attributable risk proportion was 7.5% for all fractures and 22.9% for hip fractures. Taken together, older men with low serum IGF-1 have an increased fracture risk, especially for the two most important fracture types, hip and vertebral fractures. The association between serum IGF-1 and fracture risk is partly mediated via BMD. (C) 2011 American Society for Bone and Mineral Research.},
  author       = {Ohlsson, Claes and Mellstrom, Dan and Carlzon, Daniel and Orwoll, Eric and Ljunggren, Osten and Karlsson, Magnus and Vandenput, Liesbeth},
  issn         = {1523-4681},
  keyword      = {POPULATION STUDIES,INSULIN-LIKE GROWTH FACTOR 1,AGING,MEN,FRACTURE},
  language     = {eng},
  number       = {4},
  pages        = {865--872},
  publisher    = {AMBMR},
  series       = {Journal of Bone and Mineral Research},
  title        = {Older Men With Low Serum IGF-1 Have an Increased Risk of Incident Fractures: The MrOS Sweden Study},
  url          = {http://dx.doi.org/10.1002/jbmr.281},
  volume       = {26},
  year         = {2011},
}