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Physical activity and lymphoid neoplasms in the European Prospective Investigation into Cancer and nutrition (EPIC)

van Veklhoven, Catharina M.; Khan, Aneire E.; Teucher, Birgit; Rohrmann, Sabine; Raaschou-Nielsen, Ole; Tjonneland, Anne; Overvad, Kim; Vigl, Matthaeus; Boeing, Heiner and Benetou, Vassiliki, et al. (2011) In European Journal of Cancer 47(5). p.748-760
Abstract
Background: Lymphoid neoplasms are a heterogeneous group of cancers that originate in the lymphatic cells of the immune system. Several risk factors have been identified or suggested, but they all account for only a small proportion of the lymphoid neoplasm incidence. It has been hypothesised that regular exercise may modulate the immune system and thereby reduce the risk of developing the disease. Design and methods: The European Investigation into Cancer and Nutrition (EPIC) cohort consists of 521,457 adults, recruited by 23 centres in 10 European countries. The analytical cohort included 343,756 participants, with 778 non-Hodgkin lymphoma (NHL) cases (376 men and 402 women) and 690 B-cell non-Hodgkin lymphoma (B-NHL) cases (326 men and... (More)
Background: Lymphoid neoplasms are a heterogeneous group of cancers that originate in the lymphatic cells of the immune system. Several risk factors have been identified or suggested, but they all account for only a small proportion of the lymphoid neoplasm incidence. It has been hypothesised that regular exercise may modulate the immune system and thereby reduce the risk of developing the disease. Design and methods: The European Investigation into Cancer and Nutrition (EPIC) cohort consists of 521,457 adults, recruited by 23 centres in 10 European countries. The analytical cohort included 343,756 participants, with 778 non-Hodgkin lymphoma (NHL) cases (376 men and 402 women) and 690 B-cell non-Hodgkin lymphoma (B-NHL) cases (326 men and 364 women). Multivariate Cox regression models were used to calculate hazard ratios (HR) for the association between total, recreational, occupational, and household physical activity and NHL and B-NHL risk, as well as the risk for several B-NHL subtypes. Models were stratified by study centre and age at recruitment and adjusted for various potential confounding factors. Results: We found no evidence of any effect of total physical activity on NHL (adjusted p-trend = 0.76 and 0.30 for men and women, respectively) and B-NHL risk (adjusted p-trend = 0.99 and 0.21 for men and women, respectively) for either men or women. Also no robust results were found for B-NHL subtype analyses among men or women. Conclusions: This study provided no consistent evidence for an association between various physical activity measures and the risk of lymphoid neoplasms or any of the B-NHL subtypes. (C) 2010 Elsevier Ltd. All rights reserved. (Less)
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keywords
Lymphoid neoplasm, Hodgkin lymphoma, Non-Hodgkin lymphoma, Multiple, myeloma, Lymphocytic leukaemia, Physical activity, Cohort study
in
European Journal of Cancer
volume
47
issue
5
pages
748 - 760
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000288881700014
  • scopus:79952101640
ISSN
1879-0852
DOI
10.1016/j.ejca.2010.11.010
language
English
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yes
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2bd4b73f-ca11-4e7d-b70d-c15964bda079 (old id 1925408)
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2011-05-02 09:34:21
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2017-08-13 03:23:34
@article{2bd4b73f-ca11-4e7d-b70d-c15964bda079,
  abstract     = {Background: Lymphoid neoplasms are a heterogeneous group of cancers that originate in the lymphatic cells of the immune system. Several risk factors have been identified or suggested, but they all account for only a small proportion of the lymphoid neoplasm incidence. It has been hypothesised that regular exercise may modulate the immune system and thereby reduce the risk of developing the disease. Design and methods: The European Investigation into Cancer and Nutrition (EPIC) cohort consists of 521,457 adults, recruited by 23 centres in 10 European countries. The analytical cohort included 343,756 participants, with 778 non-Hodgkin lymphoma (NHL) cases (376 men and 402 women) and 690 B-cell non-Hodgkin lymphoma (B-NHL) cases (326 men and 364 women). Multivariate Cox regression models were used to calculate hazard ratios (HR) for the association between total, recreational, occupational, and household physical activity and NHL and B-NHL risk, as well as the risk for several B-NHL subtypes. Models were stratified by study centre and age at recruitment and adjusted for various potential confounding factors. Results: We found no evidence of any effect of total physical activity on NHL (adjusted p-trend = 0.76 and 0.30 for men and women, respectively) and B-NHL risk (adjusted p-trend = 0.99 and 0.21 for men and women, respectively) for either men or women. Also no robust results were found for B-NHL subtype analyses among men or women. Conclusions: This study provided no consistent evidence for an association between various physical activity measures and the risk of lymphoid neoplasms or any of the B-NHL subtypes. (C) 2010 Elsevier Ltd. All rights reserved.},
  author       = {van Veklhoven, Catharina M. and Khan, Aneire E. and Teucher, Birgit and Rohrmann, Sabine and Raaschou-Nielsen, Ole and Tjonneland, Anne and Overvad, Kim and Vigl, Matthaeus and Boeing, Heiner and Benetou, Vassiliki and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Masala, Giovanna and Mattiello, Amalia and Krogh, Vittorio and Tumino, Rosario and Vermeulen, Roel and Monninkhof, Evelyn and May, Anne M. and Bueno-de-Mesquita, Bas and Lund, Eiliv and Ardanaz, Eva and Maria Huerta, Jose and Jakszyn, Paula and Dorronsoro, Miren and Argueelles, Marcial and Sanchez, Maria-Jose and Hallmans, Goran and Manjer, Jonas and Borgquist, Signe and Allen, Naomi E. and Travis, Ruth C. and Khaw, Kay Tee and Wareham, Nick and Boffetta, Paolo and Vineis, Paolo and Riboli, Elio},
  issn         = {1879-0852},
  keyword      = {Lymphoid neoplasm,Hodgkin lymphoma,Non-Hodgkin lymphoma,Multiple,myeloma,Lymphocytic leukaemia,Physical activity,Cohort study},
  language     = {eng},
  number       = {5},
  pages        = {748--760},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Physical activity and lymphoid neoplasms in the European Prospective Investigation into Cancer and nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1016/j.ejca.2010.11.010},
  volume       = {47},
  year         = {2011},
}