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Evaluation of depolarization changes during acute myocardial ischemia by analysis of QRS slopes.

Ringborn, Michael LU ; Romero, Daniel; Pueyo, Esther; Pahlm, Olle LU ; Wagner, Galen S; Laguna, Pablo and Platonov, Pyotr LU (2011) In Journal of Electrocardiology 44(4). p.416-424
Abstract
OBJECTIVE: This study evaluates depolarization changes in acute myocardial ischemia by analysis of QRS slopes. METHODS: In 38 patients undergoing elective percutaneous coronary intervention, changes in upward slope between Q and R waves and downward slope between R and S waves (DS) were analyzed. In leads V1 to V3, upward slope of the S wave was additionally analyzed. Ischemia was quantified by myocardial scintigraphy. Also, conventional QRS and ST measures were determined. RESULTS: QRS slope changes correlated significantly with ischemia (for DS: r = 0.71, P < .0001 for extent, and r = 0.73, P < .0001 for severity). Best corresponding correlation for conventional electrocardiogram parameters was the sum of R-wave amplitude change (r... (More)
OBJECTIVE: This study evaluates depolarization changes in acute myocardial ischemia by analysis of QRS slopes. METHODS: In 38 patients undergoing elective percutaneous coronary intervention, changes in upward slope between Q and R waves and downward slope between R and S waves (DS) were analyzed. In leads V1 to V3, upward slope of the S wave was additionally analyzed. Ischemia was quantified by myocardial scintigraphy. Also, conventional QRS and ST measures were determined. RESULTS: QRS slope changes correlated significantly with ischemia (for DS: r = 0.71, P < .0001 for extent, and r = 0.73, P < .0001 for severity). Best corresponding correlation for conventional electrocardiogram parameters was the sum of R-wave amplitude change (r = 0.63, P < .0001; r = 0.60, P < .0001) and the sum of ST-segment elevation (r = 0.67, P < .0001; r = 0.73, P < .0001). Prediction of extent and severity of ischemia increased by 12.2% and 7.1% by adding DS to ST. CONCLUSIONS: The downward slope between R and S waves correlates with ischemia and could have potential value in risk stratification in acute ischemia in addition to ST-T analysis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Electrocardiology
volume
44
issue
4
pages
416 - 424
publisher
Elsevier
external identifiers
  • wos:000292577600005
  • pmid:21524754
  • scopus:79959702194
ISSN
1532-8430
DOI
10.1016/j.jelectrocard.2011.03.005
language
English
LU publication?
yes
id
08fc20ed-e677-47bc-bf47-d2d2372d3935 (old id 1936650)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21524754?dopt=Abstract
date added to LUP
2011-05-02 16:59:10
date last changed
2017-04-23 03:09:35
@article{08fc20ed-e677-47bc-bf47-d2d2372d3935,
  abstract     = {OBJECTIVE: This study evaluates depolarization changes in acute myocardial ischemia by analysis of QRS slopes. METHODS: In 38 patients undergoing elective percutaneous coronary intervention, changes in upward slope between Q and R waves and downward slope between R and S waves (DS) were analyzed. In leads V1 to V3, upward slope of the S wave was additionally analyzed. Ischemia was quantified by myocardial scintigraphy. Also, conventional QRS and ST measures were determined. RESULTS: QRS slope changes correlated significantly with ischemia (for DS: r = 0.71, P &lt; .0001 for extent, and r = 0.73, P &lt; .0001 for severity). Best corresponding correlation for conventional electrocardiogram parameters was the sum of R-wave amplitude change (r = 0.63, P &lt; .0001; r = 0.60, P &lt; .0001) and the sum of ST-segment elevation (r = 0.67, P &lt; .0001; r = 0.73, P &lt; .0001). Prediction of extent and severity of ischemia increased by 12.2% and 7.1% by adding DS to ST. CONCLUSIONS: The downward slope between R and S waves correlates with ischemia and could have potential value in risk stratification in acute ischemia in addition to ST-T analysis.},
  author       = {Ringborn, Michael and Romero, Daniel and Pueyo, Esther and Pahlm, Olle and Wagner, Galen S and Laguna, Pablo and Platonov, Pyotr},
  issn         = {1532-8430},
  language     = {eng},
  number       = {4},
  pages        = {416--424},
  publisher    = {Elsevier},
  series       = {Journal of Electrocardiology},
  title        = {Evaluation of depolarization changes during acute myocardial ischemia by analysis of QRS slopes.},
  url          = {http://dx.doi.org/10.1016/j.jelectrocard.2011.03.005},
  volume       = {44},
  year         = {2011},
}