Advanced

Risk of acute myocardial infarction and stroke after discharge from in-hospital care due to complicated and uncomplicated peptic ulcer disease.

Sadr-Azodi, Omid; Sundquist, Jan LU ; Ji, Jianguang LU ; Lundell, Lars and Sundquist, Kristina LU (2011) In European Journal of Gastroenterology and Hepathology 23. p.461-466
Abstract
BACKGROUND: The incidence of acute cardiovascular and cerebrovascular events in patients treated for complicated or uncomplicated peptic ulcer disease (PUD) has not been ascertained completely. METHOD: All patients with in-hospital treatment due to PUD between 1987 and 2007, who did not have any past history of acute or chronic cardiovascular or cerebrovascular disease, were identified through the Swedish Patient Register. Standardized incidence ratios were calculated to compare the subsequent incidence of acute myocardial infarction (AMI), ischemic, or hemorrhagic stroke after hospital admission in six different subgroups of PUD relative to the general population. To partly account for the impact of smoking, the incidence of lung cancer... (More)
BACKGROUND: The incidence of acute cardiovascular and cerebrovascular events in patients treated for complicated or uncomplicated peptic ulcer disease (PUD) has not been ascertained completely. METHOD: All patients with in-hospital treatment due to PUD between 1987 and 2007, who did not have any past history of acute or chronic cardiovascular or cerebrovascular disease, were identified through the Swedish Patient Register. Standardized incidence ratios were calculated to compare the subsequent incidence of acute myocardial infarction (AMI), ischemic, or hemorrhagic stroke after hospital admission in six different subgroups of PUD relative to the general population. To partly account for the impact of smoking, the incidence of lung cancer in those treated for PUD was compared with that of the general population. RESULTS: A total of 84 156 patients with no past history of acute or chronic cardiovascular or cerebrovascular disease were discharged from hospital due to PUD. The risk of AMI, ischemic, or hemorrhagic stroke was increased from 2-fold to 4-fold within the first 60 days of hospitalization due to PUD compared with the general population. This risk remained 30-70% higher among all subgroups of PUD compared with the general population throughout the entire follow-up period. CONCLUSION: Patients treated in hospital for PUD have a higher risk of AMI and stroke compared with the general population. Careful surveillance of these patients seems to be indicated, particularly during the first 60 days after discharge. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Gastroenterology and Hepathology
volume
23
pages
461 - 466
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000290144500003
  • pmid:21499109
  • scopus:79955577706
ISSN
1473-5687
DOI
10.1097/MEG.0b013e328346a559
language
English
LU publication?
yes
id
f2d5453c-c6c8-4c05-afbf-7d437f03ea06 (old id 1937006)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21499109?dopt=Abstract
date added to LUP
2011-05-02 14:52:53
date last changed
2017-05-21 04:34:00
@article{f2d5453c-c6c8-4c05-afbf-7d437f03ea06,
  abstract     = {BACKGROUND: The incidence of acute cardiovascular and cerebrovascular events in patients treated for complicated or uncomplicated peptic ulcer disease (PUD) has not been ascertained completely. METHOD: All patients with in-hospital treatment due to PUD between 1987 and 2007, who did not have any past history of acute or chronic cardiovascular or cerebrovascular disease, were identified through the Swedish Patient Register. Standardized incidence ratios were calculated to compare the subsequent incidence of acute myocardial infarction (AMI), ischemic, or hemorrhagic stroke after hospital admission in six different subgroups of PUD relative to the general population. To partly account for the impact of smoking, the incidence of lung cancer in those treated for PUD was compared with that of the general population. RESULTS: A total of 84 156 patients with no past history of acute or chronic cardiovascular or cerebrovascular disease were discharged from hospital due to PUD. The risk of AMI, ischemic, or hemorrhagic stroke was increased from 2-fold to 4-fold within the first 60 days of hospitalization due to PUD compared with the general population. This risk remained 30-70% higher among all subgroups of PUD compared with the general population throughout the entire follow-up period. CONCLUSION: Patients treated in hospital for PUD have a higher risk of AMI and stroke compared with the general population. Careful surveillance of these patients seems to be indicated, particularly during the first 60 days after discharge.},
  author       = {Sadr-Azodi, Omid and Sundquist, Jan and Ji, Jianguang and Lundell, Lars and Sundquist, Kristina},
  issn         = {1473-5687},
  language     = {eng},
  pages        = {461--466},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Gastroenterology and Hepathology},
  title        = {Risk of acute myocardial infarction and stroke after discharge from in-hospital care due to complicated and uncomplicated peptic ulcer disease.},
  url          = {http://dx.doi.org/10.1097/MEG.0b013e328346a559},
  volume       = {23},
  year         = {2011},
}