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Differential gene expression analysis of placentas with increased vascular resistance and pre-eclampsia using whole-genome microarrays.

Centlow, Magnus; Wingren, Christer; Borrebaeck, Carl; Brownstein, M J and Hansson, Stefan LU (2011) In Journal of Pregnancy 2011(Mar 8).
Abstract
Pre-eclampsia is a pregnancy complication characterized by hypertension and proteinuria. There are several factors associated with an increased risk of developing pre-eclampsia, one of which is increased uterine artery resistance, referred to as "notching". However, some women do not progress into pre-eclampsia whereas others may have a higher risk of doing so. The placenta, central in pre-eclampsia pathology, may express genes associated with either protection or progression into pre-eclampsia. In order to search for genes associated with protection or progression, whole-genome profiling was performed. Placental tissue from 15 controls, 10 pre-eclamptic, 5 pre-eclampsia with notching, and 5 with notching only were analyzed using... (More)
Pre-eclampsia is a pregnancy complication characterized by hypertension and proteinuria. There are several factors associated with an increased risk of developing pre-eclampsia, one of which is increased uterine artery resistance, referred to as "notching". However, some women do not progress into pre-eclampsia whereas others may have a higher risk of doing so. The placenta, central in pre-eclampsia pathology, may express genes associated with either protection or progression into pre-eclampsia. In order to search for genes associated with protection or progression, whole-genome profiling was performed. Placental tissue from 15 controls, 10 pre-eclamptic, 5 pre-eclampsia with notching, and 5 with notching only were analyzed using microarray and antibody microarrays to study some of the same gene product and functionally related ones. The microarray showed 148 genes to be significantly altered between the four groups. In the preeclamptic group compared to notch only, there was increased expression of genes related to chemotaxis and the NF-kappa B pathway and decreased expression of genes related to antigen processing and presentation, such as human leukocyte antigen B. Our results indicate that progression of pre-eclampsia from notching may involve the development of inflammation. Increased expression of antigen-presenting genes, as seen in the notch-only placenta, may prevent this inflammatory response and, thereby, protect the patient from developing pre-eclampsia. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Pregnancy
volume
2011
issue
Mar 8
publisher
Hindawi Publishing Corporation
external identifiers
  • pmid:21490790
  • scopus:84862506779
ISSN
2090-2727
DOI
10.1155/2011/472354
project
CREATE Health
language
English
LU publication?
yes
id
481fc47d-9b99-46f7-8636-b45f8915ebd4 (old id 1937123)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21490790?dopt=Abstract
date added to LUP
2011-05-02 14:20:20
date last changed
2017-06-04 04:32:15
@article{481fc47d-9b99-46f7-8636-b45f8915ebd4,
  abstract     = {Pre-eclampsia is a pregnancy complication characterized by hypertension and proteinuria. There are several factors associated with an increased risk of developing pre-eclampsia, one of which is increased uterine artery resistance, referred to as "notching". However, some women do not progress into pre-eclampsia whereas others may have a higher risk of doing so. The placenta, central in pre-eclampsia pathology, may express genes associated with either protection or progression into pre-eclampsia. In order to search for genes associated with protection or progression, whole-genome profiling was performed. Placental tissue from 15 controls, 10 pre-eclamptic, 5 pre-eclampsia with notching, and 5 with notching only were analyzed using microarray and antibody microarrays to study some of the same gene product and functionally related ones. The microarray showed 148 genes to be significantly altered between the four groups. In the preeclamptic group compared to notch only, there was increased expression of genes related to chemotaxis and the NF-kappa B pathway and decreased expression of genes related to antigen processing and presentation, such as human leukocyte antigen B. Our results indicate that progression of pre-eclampsia from notching may involve the development of inflammation. Increased expression of antigen-presenting genes, as seen in the notch-only placenta, may prevent this inflammatory response and, thereby, protect the patient from developing pre-eclampsia.},
  articleno    = {472354},
  author       = {Centlow, Magnus and Wingren, Christer and Borrebaeck, Carl and Brownstein, M J and Hansson, Stefan},
  issn         = {2090-2727},
  language     = {eng},
  number       = {Mar 8},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Journal of Pregnancy},
  title        = {Differential gene expression analysis of placentas with increased vascular resistance and pre-eclampsia using whole-genome microarrays.},
  url          = {http://dx.doi.org/10.1155/2011/472354},
  volume       = {2011},
  year         = {2011},
}