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Familial risk factors shared by venous thromboembolism and cancer: A nationwide epidemiological study of Swedish families.

Zöller, Bengt LU ; Ji, Jianguang LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2011) In Thrombosis Research 128. p.141-148
Abstract
BACKGROUND: Cancer and venous thromboembolism (VTE) are associated disorders. In the present nationwide study, we analyzed the risk of cancer in siblings, offspring and spouses of individuals hospitalized for VTE (and vice versa) with the aim of identifying shared familial risk factors for cancer and VTE. MATERIAL AND METHODS: The Multigeneration Register was linked to the Swedish Hospital Discharge Register and the Swedish Cancer Registry. Associations between the familial risks for VTE and cancer were examined by measuring the risk of developing specific cancers in the offspring of individuals diagnosed with VTE, and the risk of VTE in the offspring of individuals diagnosed with specific cancers. The analysis was repeated for siblings... (More)
BACKGROUND: Cancer and venous thromboembolism (VTE) are associated disorders. In the present nationwide study, we analyzed the risk of cancer in siblings, offspring and spouses of individuals hospitalized for VTE (and vice versa) with the aim of identifying shared familial risk factors for cancer and VTE. MATERIAL AND METHODS: The Multigeneration Register was linked to the Swedish Hospital Discharge Register and the Swedish Cancer Registry. Associations between the familial risks for VTE and cancer were examined by measuring the risk of developing specific cancers in the offspring of individuals diagnosed with VTE, and the risk of VTE in the offspring of individuals diagnosed with specific cancers. The analysis was repeated for siblings and spouses. RESULTS: No overall associations between cancer and VTE were observed in parent-offspring pairs. In contrast, the risk of cancer was slightly increased in siblings of VTE patients (OR 1.03, 95% CI 1.01-1.06), and the risk of VTE was also increased in siblings of cancer patients (OR 1.07, 95% CI 1.04-1.10). Risks of cancer were also slightly increased in the husbands (OR 1.09, 95% CI 1.07-1.11) and wives (OR 1.02, 95% 1.00-1.05) of individuals with VTE. CONCLUSION: The present study provides evidence for minor familial risk factors shared by VTE and common cancers. These could be mostly environmental because of the positive associations in the spouse and sibling analyses and negative associations in the parent-offspring analysis, although the possibility of shared genetic risk factors also exists. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Thrombosis Research
volume
128
pages
141 - 148
external identifiers
  • wos:000292773900008
  • pmid:21489607
  • scopus:79960408855
ISSN
1879-2472
DOI
10.1016/j.thromres.2011.03.020
language
English
LU publication?
yes
id
03356d86-9857-4920-80a7-1661d14b82f9 (old id 1937145)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21489607?dopt=Abstract
date added to LUP
2011-05-02 14:03:47
date last changed
2017-01-01 07:40:55
@article{03356d86-9857-4920-80a7-1661d14b82f9,
  abstract     = {BACKGROUND: Cancer and venous thromboembolism (VTE) are associated disorders. In the present nationwide study, we analyzed the risk of cancer in siblings, offspring and spouses of individuals hospitalized for VTE (and vice versa) with the aim of identifying shared familial risk factors for cancer and VTE. MATERIAL AND METHODS: The Multigeneration Register was linked to the Swedish Hospital Discharge Register and the Swedish Cancer Registry. Associations between the familial risks for VTE and cancer were examined by measuring the risk of developing specific cancers in the offspring of individuals diagnosed with VTE, and the risk of VTE in the offspring of individuals diagnosed with specific cancers. The analysis was repeated for siblings and spouses. RESULTS: No overall associations between cancer and VTE were observed in parent-offspring pairs. In contrast, the risk of cancer was slightly increased in siblings of VTE patients (OR 1.03, 95% CI 1.01-1.06), and the risk of VTE was also increased in siblings of cancer patients (OR 1.07, 95% CI 1.04-1.10). Risks of cancer were also slightly increased in the husbands (OR 1.09, 95% CI 1.07-1.11) and wives (OR 1.02, 95% 1.00-1.05) of individuals with VTE. CONCLUSION: The present study provides evidence for minor familial risk factors shared by VTE and common cancers. These could be mostly environmental because of the positive associations in the spouse and sibling analyses and negative associations in the parent-offspring analysis, although the possibility of shared genetic risk factors also exists.},
  author       = {Zöller, Bengt and Ji, Jianguang and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1879-2472},
  language     = {eng},
  pages        = {141--148},
  series       = {Thrombosis Research},
  title        = {Familial risk factors shared by venous thromboembolism and cancer: A nationwide epidemiological study of Swedish families.},
  url          = {http://dx.doi.org/10.1016/j.thromres.2011.03.020},
  volume       = {128},
  year         = {2011},
}