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High constant incidence rates of second primary cancers of the head and neck: a pooled analysis of 13 cancer registries

Bosetti, Cristina; Scelo, Ghislaine; Chuang, Shu-Chun; Tonita, Jon M.; Tamaro, Sharon; Jonasson, Jon G.; Kliewer, Erich V.; Hemminki, Kari LU ; Weiderpass, Elisabete and Pukkala, Eero, et al. (2011) In International Journal of Cancer 129(1). p.173-179
Abstract
Scanty data are available on the incidence (i.e., the absolute risk) of second cancers of the head and neck (HN) and its pattern with age. We investigated this issue using data from a multicentric study of 13 population-based cancer registries from Europe, Canada, Australia and Singapore for the years 1943-2000. A total of 99,257 patients had a first primary HN cancer (15,985 tongue, 22,378 mouth, 20,758 pharyngeal, and 40,190 laryngeal cancer), contributing to 489,855 person-years of follow-up. A total of 1,294 of the patients (1.3%) were diagnosed with second HN cancers (342 tongue, 345 mouth, 418 pharynx and 189 larynx). Male incidence rates of first HN cancer steeply increased from 0.68/100,000 at age 30-34 to 46.2/100,000 at age... (More)
Scanty data are available on the incidence (i.e., the absolute risk) of second cancers of the head and neck (HN) and its pattern with age. We investigated this issue using data from a multicentric study of 13 population-based cancer registries from Europe, Canada, Australia and Singapore for the years 1943-2000. A total of 99,257 patients had a first primary HN cancer (15,985 tongue, 22,378 mouth, 20,758 pharyngeal, and 40,190 laryngeal cancer), contributing to 489,855 person-years of follow-up. A total of 1,294 of the patients (1.3%) were diagnosed with second HN cancers (342 tongue, 345 mouth, 418 pharynx and 189 larynx). Male incidence rates of first HN cancer steeply increased from 0.68/100,000 at age 30-34 to 46.2/100,000 at age 70-74, and leveled off at older age; female incidence increased from 0.50/100,000 at age 30-34 to 16.5/100,000 at age 80-84. However, age-specific incidence of second HN cancers after a first HN cancer in men was around 200-300/100,000 between age 40-44 and age 70-74 and tended to decline at subsequent ages (150/100,000 at age 80-84); in women, incidence of second HN cancers was around 200-300/100,000 between age 45-49 and 80-84. The patterns of age-specific incidence were consistent for different subsites of second HN cancer and sexes; moreover, they were similar for age-specific incidence of first primary HN cancer in patients who subsequently developed a second HN cancer. The incidence of second HN cancers does not increase with age, but remains constant, or if anything, decreases with advancing age. (Less)
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publication status
published
subject
keywords
second neoplasms, head and neck cancer, incidence, age
in
International Journal of Cancer
volume
129
issue
1
pages
173 - 179
publisher
John Wiley & Sons
external identifiers
  • wos:000289987300017
  • scopus:79955449361
ISSN
0020-7136
DOI
10.1002/ijc.25652
language
English
LU publication?
yes
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af6fc9b7-8d4e-4c4c-8398-7b4351eec82a (old id 1964431)
date added to LUP
2011-06-01 10:37:58
date last changed
2017-03-12 03:06:48
@article{af6fc9b7-8d4e-4c4c-8398-7b4351eec82a,
  abstract     = {Scanty data are available on the incidence (i.e., the absolute risk) of second cancers of the head and neck (HN) and its pattern with age. We investigated this issue using data from a multicentric study of 13 population-based cancer registries from Europe, Canada, Australia and Singapore for the years 1943-2000. A total of 99,257 patients had a first primary HN cancer (15,985 tongue, 22,378 mouth, 20,758 pharyngeal, and 40,190 laryngeal cancer), contributing to 489,855 person-years of follow-up. A total of 1,294 of the patients (1.3%) were diagnosed with second HN cancers (342 tongue, 345 mouth, 418 pharynx and 189 larynx). Male incidence rates of first HN cancer steeply increased from 0.68/100,000 at age 30-34 to 46.2/100,000 at age 70-74, and leveled off at older age; female incidence increased from 0.50/100,000 at age 30-34 to 16.5/100,000 at age 80-84. However, age-specific incidence of second HN cancers after a first HN cancer in men was around 200-300/100,000 between age 40-44 and age 70-74 and tended to decline at subsequent ages (150/100,000 at age 80-84); in women, incidence of second HN cancers was around 200-300/100,000 between age 45-49 and 80-84. The patterns of age-specific incidence were consistent for different subsites of second HN cancer and sexes; moreover, they were similar for age-specific incidence of first primary HN cancer in patients who subsequently developed a second HN cancer. The incidence of second HN cancers does not increase with age, but remains constant, or if anything, decreases with advancing age.},
  author       = {Bosetti, Cristina and Scelo, Ghislaine and Chuang, Shu-Chun and Tonita, Jon M. and Tamaro, Sharon and Jonasson, Jon G. and Kliewer, Erich V. and Hemminki, Kari and Weiderpass, Elisabete and Pukkala, Eero and Tracey, Elizabeth and Olsen, Jorgen H. and Pompe-Kirn, Vera and Brewster, David H. and Martos, Carmen and Chia, Kee-Seng and Brennan, Paul and Hashibe, Mia and Levi, Fabio and La Vecchia, Carlo and Boffetta, Paolo},
  issn         = {0020-7136},
  keyword      = {second neoplasms,head and neck cancer,incidence,age},
  language     = {eng},
  number       = {1},
  pages        = {173--179},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {High constant incidence rates of second primary cancers of the head and neck: a pooled analysis of 13 cancer registries},
  url          = {http://dx.doi.org/10.1002/ijc.25652},
  volume       = {129},
  year         = {2011},
}