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Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice

Niemiec, T.; Sikorska, J.; Harrison, A.; Szmidt, M.; Sawosz, E.; Wirth-Dzieciolowska, E.; Wilczak, J. and Pierzynowski, Stefan LU (2011) In Journal of Physiology and Pharmacology 62(1). p.37-43
Abstract
The objective of this study was to evaluate the effect of alpha-ketoglutarate on redox state parameters and arterial elasticity in elderly mice. Mice in the control group were fed with standard diet, while the experimental animals received the diet supplemented either with calcium (Ca-AKG) or sodium salt of alpha-ketoglutarate (Na-AKG). The experimental animals were divided into 4 groups with 10 individuals in each: control I (12 months old), control II (2 months old), experimental group I fed with Ca-AKG (12 months old) and experimental group II fed with Na-AKG (12 months old). Mice treated with Ca-AKG as well as the control II animals demonstrated significantly higher level of total antioxidant status (TAS), comparing to the control I... (More)
The objective of this study was to evaluate the effect of alpha-ketoglutarate on redox state parameters and arterial elasticity in elderly mice. Mice in the control group were fed with standard diet, while the experimental animals received the diet supplemented either with calcium (Ca-AKG) or sodium salt of alpha-ketoglutarate (Na-AKG). The experimental animals were divided into 4 groups with 10 individuals in each: control I (12 months old), control II (2 months old), experimental group I fed with Ca-AKG (12 months old) and experimental group II fed with Na-AKG (12 months old). Mice treated with Ca-AKG as well as the control II animals demonstrated significantly higher level of total antioxidant status (TAS), comparing to the control I animals and those treated with Ca-AKG. Thiobarbituric acid reactive substances (TBARS) level in blood plasma was found significantly lower in young and Ca-AKG treated mice. TBARS liver concentration was significantly different in each examined group. The study also demonstrates the decrease in TBARS level in Ca-AKG treated animals. Treatment with Na-AKG significantly increased glutathione peroxidase activity and decreased the activity of superoxide dismutase. The presented results suggest that Ca-AKG protects the organism against the free radicals related elderly processes. The study presents also the effect of Ca-AKG treatment on arterial elastic characteristics in elderly mice. The beneficial effect of Ca-AKG on ageing organisms was confirmed via redox state stabilization and blood vessel elasticity improvement. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alpha-ketoglutarate, aorta elasticity, glutathione peroxidase, redox, reactive oxygen species, total antioxidant status, superoxide, dismutase, thiobarbituric acid reactive substances
in
Journal of Physiology and Pharmacology
volume
62
issue
1
pages
37 - 43
publisher
Polish Physiological Society
external identifiers
  • wos:000289542300005
  • scopus:79954559816
ISSN
0867-5910
language
English
LU publication?
yes
id
cace6242-b46d-4117-ba54-b222cc7146cb (old id 1965566)
alternative location
http://www.jpp.krakow.pl/journal/archive/02_11/articles/05_article.html
date added to LUP
2011-05-20 14:20:43
date last changed
2017-08-13 03:49:53
@article{cace6242-b46d-4117-ba54-b222cc7146cb,
  abstract     = {The objective of this study was to evaluate the effect of alpha-ketoglutarate on redox state parameters and arterial elasticity in elderly mice. Mice in the control group were fed with standard diet, while the experimental animals received the diet supplemented either with calcium (Ca-AKG) or sodium salt of alpha-ketoglutarate (Na-AKG). The experimental animals were divided into 4 groups with 10 individuals in each: control I (12 months old), control II (2 months old), experimental group I fed with Ca-AKG (12 months old) and experimental group II fed with Na-AKG (12 months old). Mice treated with Ca-AKG as well as the control II animals demonstrated significantly higher level of total antioxidant status (TAS), comparing to the control I animals and those treated with Ca-AKG. Thiobarbituric acid reactive substances (TBARS) level in blood plasma was found significantly lower in young and Ca-AKG treated mice. TBARS liver concentration was significantly different in each examined group. The study also demonstrates the decrease in TBARS level in Ca-AKG treated animals. Treatment with Na-AKG significantly increased glutathione peroxidase activity and decreased the activity of superoxide dismutase. The presented results suggest that Ca-AKG protects the organism against the free radicals related elderly processes. The study presents also the effect of Ca-AKG treatment on arterial elastic characteristics in elderly mice. The beneficial effect of Ca-AKG on ageing organisms was confirmed via redox state stabilization and blood vessel elasticity improvement.},
  author       = {Niemiec, T. and Sikorska, J. and Harrison, A. and Szmidt, M. and Sawosz, E. and Wirth-Dzieciolowska, E. and Wilczak, J. and Pierzynowski, Stefan},
  issn         = {0867-5910},
  keyword      = {alpha-ketoglutarate,aorta elasticity,glutathione peroxidase,redox,reactive oxygen species,total antioxidant status,superoxide,dismutase,thiobarbituric acid reactive substances},
  language     = {eng},
  number       = {1},
  pages        = {37--43},
  publisher    = {Polish Physiological Society},
  series       = {Journal of Physiology and Pharmacology},
  title        = {Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice},
  volume       = {62},
  year         = {2011},
}