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Long-term course of Mycobacterium tuberculosis infection in Swedish birth cohorts during the twentieth century.

Winqvist, Niclas LU ; Björk, Jonas LU ; Miörner, Håkan LU and Björkman, Per LU (2011) In The International Journal of Tuberculosis and Lung Disease 15(6). p.736-740
Abstract
Abstract

SETTING:

Sweden under transition from high to low tuberculosis (TB) incidence from 1920 to 2009.



OBJECTIVE:

To correlate estimates of TB infection in birth cohorts with the longitudinal incidence of active TB to assess the long-term risk and time pattern of reactivated TB.



DESIGN:

Time trend analysis on TB incidence using age-cohort modelling.



RESULTS:

The overall TB incidence decreased from 700 per 100 000 population in 1920 to 1.4 in 2009 in the Sweden-born population. The estimated disease rate (number of cases divided by the estimated number of infected in 1967), for each birth cohort between 1920 and 1940, was stable on a... (More)
Abstract

SETTING:

Sweden under transition from high to low tuberculosis (TB) incidence from 1920 to 2009.



OBJECTIVE:

To correlate estimates of TB infection in birth cohorts with the longitudinal incidence of active TB to assess the long-term risk and time pattern of reactivated TB.



DESIGN:

Time trend analysis on TB incidence using age-cohort modelling.



RESULTS:

The overall TB incidence decreased from 700 per 100 000 population in 1920 to 1.4 in 2009 in the Sweden-born population. The estimated disease rate (number of cases divided by the estimated number of infected in 1967), for each birth cohort between 1920 and 1940, was stable on a level between 9.8% and 10.7%. The reactivation rate of latent TB infection (LTBI) was 2% after 1967, when indigenous transmission had disappeared.



CONCLUSION:

Although approximately 10% of persons with LTBI developed active TB, the majority of cases occurred shortly after infection, and the rates of reactivation declined over time. This indicates extensive spontaneous clearance of LTBI (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The International Journal of Tuberculosis and Lung Disease
volume
15
issue
6
pages
736 - 740
publisher
International Union against Tuberculosis and Lung Disease
external identifiers
  • wos:000293724800006
  • pmid:21575291
  • scopus:79955855159
ISSN
1815-7920
DOI
10.5588/ijtld.10.0683
language
English
LU publication?
yes
id
c96f2b44-656e-4eae-b5de-aa2d2adc0723 (old id 1972525)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21575291?dopt=Abstract
date added to LUP
2011-06-07 20:00:14
date last changed
2017-11-19 04:16:09
@article{c96f2b44-656e-4eae-b5de-aa2d2adc0723,
  abstract     = {Abstract<br/><br>
SETTING:<br/><br>
Sweden under transition from high to low tuberculosis (TB) incidence from 1920 to 2009.<br/><br>
<br/><br>
OBJECTIVE:<br/><br>
To correlate estimates of TB infection in birth cohorts with the longitudinal incidence of active TB to assess the long-term risk and time pattern of reactivated TB.<br/><br>
<br/><br>
DESIGN:<br/><br>
Time trend analysis on TB incidence using age-cohort modelling.<br/><br>
<br/><br>
RESULTS:<br/><br>
The overall TB incidence decreased from 700 per 100 000 population in 1920 to 1.4 in 2009 in the Sweden-born population. The estimated disease rate (number of cases divided by the estimated number of infected in 1967), for each birth cohort between 1920 and 1940, was stable on a level between 9.8% and 10.7%. The reactivation rate of latent TB infection (LTBI) was 2% after 1967, when indigenous transmission had disappeared.<br/><br>
<br/><br>
CONCLUSION:<br/><br>
Although approximately 10% of persons with LTBI developed active TB, the majority of cases occurred shortly after infection, and the rates of reactivation declined over time. This indicates extensive spontaneous clearance of LTBI},
  author       = {Winqvist, Niclas and Björk, Jonas and Miörner, Håkan and Björkman, Per},
  issn         = {1815-7920},
  language     = {eng},
  number       = {6},
  pages        = {736--740},
  publisher    = {International Union against Tuberculosis and Lung Disease},
  series       = {The International Journal of Tuberculosis and Lung Disease},
  title        = {Long-term course of Mycobacterium tuberculosis infection in Swedish birth cohorts during the twentieth century.},
  url          = {http://dx.doi.org/10.5588/ijtld.10.0683},
  volume       = {15},
  year         = {2011},
}