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Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.

Lambertsen, Kate L ; Deierborg, Tomas LU ; Gregersen, Rikke ; Clausen, Bettina H ; Wirenfeldt, Martin ; Nielsen, Helle H ; Dalmau, Ishar ; Diemer, Nils H ; Dagnaes-Hansen, Frederik and Johansen, Flemming F , et al. (2011) In Journal of Neuropathology and Experimental Neurology 70(6). p.481-494
Abstract
Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation... (More)
Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation of BM-derived cells was observed in BM-chimeric rats. These results suggest that reactive microglia in rats originate from resident microglia, whereas they have a mixed BM-derived and resident origin in mice, depending on the severity of ischemic tissue damage. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuropathology and Experimental Neurology
volume
70
issue
6
pages
481 - 494
publisher
American Association of Neuropathologists
external identifiers
  • wos:000290751700007
  • pmid:21572335
  • scopus:79957472286
ISSN
1554-6578
DOI
10.1097/NEN.0b013e31821db3aa
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
id
bfceca6f-54f0-414e-97c3-f24e7a997084 (old id 1972579)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21572335?dopt=Abstract
date added to LUP
2016-04-04 09:12:02
date last changed
2022-02-06 01:52:22
@article{bfceca6f-54f0-414e-97c3-f24e7a997084,
  abstract     = {{Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation of BM-derived cells was observed in BM-chimeric rats. These results suggest that reactive microglia in rats originate from resident microglia, whereas they have a mixed BM-derived and resident origin in mice, depending on the severity of ischemic tissue damage.}},
  author       = {{Lambertsen, Kate L and Deierborg, Tomas and Gregersen, Rikke and Clausen, Bettina H and Wirenfeldt, Martin and Nielsen, Helle H and Dalmau, Ishar and Diemer, Nils H and Dagnaes-Hansen, Frederik and Johansen, Flemming F and Keating, Armand and Finsen, Bente}},
  issn         = {{1554-6578}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{481--494}},
  publisher    = {{American Association of Neuropathologists}},
  series       = {{Journal of Neuropathology and Experimental Neurology}},
  title        = {{Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.}},
  url          = {{http://dx.doi.org/10.1097/NEN.0b013e31821db3aa}},
  doi          = {{10.1097/NEN.0b013e31821db3aa}},
  volume       = {{70}},
  year         = {{2011}},
}