Advanced

Matrix Metalloproteinases - keys to healthier blood vessels in diabetes?

Mulder, Hindrik LU (2011) In Journal of Endocrinology 210(1). p.1-2
Abstract
In this issue of J Endocrinol, Schuyler et al. show that intimal lesions in atherosclerosis-prone diabetic apoE-/- mice are reduced by insulin treatment. An increase of metalloproteinase-9 expression was observed in untreated diabetic apoE-/- mice; this was absent in insulin-treated mice. The study suggests that hindering of tissue-remodeling metalloproteinases may account for the beneficial effects of proper metabolic control in patients with diabetes. This clinically relevant finding prompts further exploration.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Endocrinology
volume
210
issue
1
pages
1 - 2
publisher
Society for Endocrinology
external identifiers
  • wos:000291633800001
  • pmid:21555344
  • scopus:79960291849
ISSN
1479-6805
DOI
10.1530/JOE-11-0168
language
English
LU publication?
yes
id
da06ea05-cb3b-4eb3-9fd7-fa346c9a7b8d (old id 1973036)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21555344?dopt=Abstract
date added to LUP
2011-06-07 14:48:08
date last changed
2017-01-01 03:16:54
@article{da06ea05-cb3b-4eb3-9fd7-fa346c9a7b8d,
  abstract     = {In this issue of J Endocrinol, Schuyler et al. show that intimal lesions in atherosclerosis-prone diabetic apoE-/- mice are reduced by insulin treatment. An increase of metalloproteinase-9 expression was observed in untreated diabetic apoE-/- mice; this was absent in insulin-treated mice. The study suggests that hindering of tissue-remodeling metalloproteinases may account for the beneficial effects of proper metabolic control in patients with diabetes. This clinically relevant finding prompts further exploration.},
  author       = {Mulder, Hindrik},
  issn         = {1479-6805},
  language     = {eng},
  number       = {1},
  pages        = {1--2},
  publisher    = {Society for Endocrinology},
  series       = {Journal of Endocrinology},
  title        = {Matrix Metalloproteinases - keys to healthier blood vessels in diabetes?},
  url          = {http://dx.doi.org/10.1530/JOE-11-0168},
  volume       = {210},
  year         = {2011},
}