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Collagen levels are normalized after decompression of experimentally obstructed colon

Rehn, Martin LU ; Agren, M. S. and Syk, Ingvar LU (2011) In Colorectal Disease 13(7). p.165-169
Abstract
Aim Our aim was to define the dynamics in collagen concentrations in the large bowel wall following decompression of experimental obstruction. Method Colonic obstruction was created in 28 male rats by the placement of a silicone ring around the distal colon. The ring was removed after 4 days to mimic endoscopical decompression by stent deployment. Colon circumference and collagen concentration were measured proximal to the obstructed segment immediately and at 3 and 10 days after decompression. The corresponding colonic sites of 23 sham-operated and eight nonoperated control animals were subjected to identical analyses. Results Four days of obstruction resulted in a more than twofold increase in colonic circumference (20 vs 8 mm), with a... (More)
Aim Our aim was to define the dynamics in collagen concentrations in the large bowel wall following decompression of experimental obstruction. Method Colonic obstruction was created in 28 male rats by the placement of a silicone ring around the distal colon. The ring was removed after 4 days to mimic endoscopical decompression by stent deployment. Colon circumference and collagen concentration were measured proximal to the obstructed segment immediately and at 3 and 10 days after decompression. The corresponding colonic sites of 23 sham-operated and eight nonoperated control animals were subjected to identical analyses. Results Four days of obstruction resulted in a more than twofold increase in colonic circumference (20 vs 8 mm), with a concomitant 43% reduction (P = 0.001) in collagen concentration in the bowel wall proximal to the obstruction compared with sham animals. Three days after decompression, collagen concentrations remained reduced (P < 0.05), while there was no significant difference after 10 days with either sham-operated or nonoperated controls. Colonic circumference of the obstructed colon remained slightly distended (11 mm) on day 10 and tended to correlate (r(S) = 0.51, P = 0.053) with total matrix metalloproteinase activity. Conclusion The marked reduction in collagen concentration in an experimentally obstructed colon is normalized 10 days after decompression. These findings may have clinical implications for the timing of surgical resection. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Intestinal healing, collagen metabolism, matrix metalloproteinase
in
Colorectal Disease
volume
13
issue
7
pages
165 - 169
publisher
Wiley-Blackwell
external identifiers
  • wos:000291402400001
  • pmid:21651691
  • scopus:79958710663
ISSN
1462-8910
DOI
10.1111/j.1463-1318.2011.02633.x
language
English
LU publication?
yes
id
c484cfe1-fd2d-4fdf-8569-898242bc951b (old id 1984986)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21651691?dopt=Abstract
date added to LUP
2011-07-01 09:11:32
date last changed
2017-01-01 03:41:37
@article{c484cfe1-fd2d-4fdf-8569-898242bc951b,
  abstract     = {Aim Our aim was to define the dynamics in collagen concentrations in the large bowel wall following decompression of experimental obstruction. Method Colonic obstruction was created in 28 male rats by the placement of a silicone ring around the distal colon. The ring was removed after 4 days to mimic endoscopical decompression by stent deployment. Colon circumference and collagen concentration were measured proximal to the obstructed segment immediately and at 3 and 10 days after decompression. The corresponding colonic sites of 23 sham-operated and eight nonoperated control animals were subjected to identical analyses. Results Four days of obstruction resulted in a more than twofold increase in colonic circumference (20 vs 8 mm), with a concomitant 43% reduction (P = 0.001) in collagen concentration in the bowel wall proximal to the obstruction compared with sham animals. Three days after decompression, collagen concentrations remained reduced (P &lt; 0.05), while there was no significant difference after 10 days with either sham-operated or nonoperated controls. Colonic circumference of the obstructed colon remained slightly distended (11 mm) on day 10 and tended to correlate (r(S) = 0.51, P = 0.053) with total matrix metalloproteinase activity. Conclusion The marked reduction in collagen concentration in an experimentally obstructed colon is normalized 10 days after decompression. These findings may have clinical implications for the timing of surgical resection.},
  author       = {Rehn, Martin and Agren, M. S. and Syk, Ingvar},
  issn         = {1462-8910},
  keyword      = {Intestinal healing,collagen metabolism,matrix metalloproteinase},
  language     = {eng},
  number       = {7},
  pages        = {165--169},
  publisher    = {Wiley-Blackwell},
  series       = {Colorectal Disease},
  title        = {Collagen levels are normalized after decompression of experimentally obstructed colon},
  url          = {http://dx.doi.org/10.1111/j.1463-1318.2011.02633.x},
  volume       = {13},
  year         = {2011},
}