Advanced

Retinol-Binding Protein 4 in Young Men With Low Versus Normal Birth Weight: Physiological Response to Short-Term Overfeeding

Ribel-Madsen, Rasmus; Brons, Charlotte; Friedrichsen, Martin; Poulsen, Pernille and Vaag, Allan LU (2011) In Obesity 19(6). p.1304-1306
Abstract
Retinol-binding protein 4 (RBP4) is a plasma protein which is elevated in obesity and type 2 diabetes. We aimed to investigate whether RBP4 represents a mechanism underlying the associations between low birth weight (LBW), high-fat diet, and insulin resistance. Forty-six young, lean men with low (n = 20) or normal (n = 26) birth weight underwent a 5-day high-fat high-calorie (HFHC) dietary intervention. In vivo glucose metabolism was assessed by euglycemic-hyperinsulinemic clamp, glucose tracer and intravenous glucose tolerance test techniques. Body composition was measured by a dual-energy x-ray absorptiometry scan, and plasma RBP4 by an enzyme-linked immunosorbent assay. RBP4 was not associated with birth weight, but with BMI (beta = 0.9... (More)
Retinol-binding protein 4 (RBP4) is a plasma protein which is elevated in obesity and type 2 diabetes. We aimed to investigate whether RBP4 represents a mechanism underlying the associations between low birth weight (LBW), high-fat diet, and insulin resistance. Forty-six young, lean men with low (n = 20) or normal (n = 26) birth weight underwent a 5-day high-fat high-calorie (HFHC) dietary intervention. In vivo glucose metabolism was assessed by euglycemic-hyperinsulinemic clamp, glucose tracer and intravenous glucose tolerance test techniques. Body composition was measured by a dual-energy x-ray absorptiometry scan, and plasma RBP4 by an enzyme-linked immunosorbent assay. RBP4 was not associated with birth weight, but with BMI (beta = 0.9 mu g/ml (0.08;1.8) (95% confidence interval), P = 0.03) and plasma levels of low-density lipoprotein cholesterol (beta = 5.3 mu g/ml (1.9;8.7), P = 0.03) and triglycerides (beta = 15.4 mu g/ml (9.5;21.3), P < 0.001). Under baseline diet conditions, RBP4 was associated with decreased disposition index (D-i) (beta = -2.4% (-4.5%;-0.2%), P = 0.04) and increased basal hepatic glucose production rate (HGP) (beta = 0.02 mg kg(-1) min(-1) (0.002;0.04), P = 0.03), but not associated with peripheral glucose disposal rate or hepatic insulin resistance index. RBP4 levels were not influenced by overfeeding or related to peripheral and hepatic insulin resistance provoked by the dietary intervention. In conclusion, plasma RBP4 in young men associates with components of the metabolic syndrome, but is not determined by birth weight and seems not to be involved in short-term high-fat diet-induced insulin resistance. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obesity
volume
19
issue
6
pages
1304 - 1306
publisher
Nature Publishing Group
external identifiers
  • wos:000291021600029
  • scopus:79957452695
ISSN
1930-739X
DOI
10.1038/oby.2010.311
language
English
LU publication?
yes
id
8eb04ea2-273c-4944-86a5-c1a2ff866aa3 (old id 1985249)
date added to LUP
2011-07-01 09:06:26
date last changed
2017-01-01 04:12:48
@article{8eb04ea2-273c-4944-86a5-c1a2ff866aa3,
  abstract     = {Retinol-binding protein 4 (RBP4) is a plasma protein which is elevated in obesity and type 2 diabetes. We aimed to investigate whether RBP4 represents a mechanism underlying the associations between low birth weight (LBW), high-fat diet, and insulin resistance. Forty-six young, lean men with low (n = 20) or normal (n = 26) birth weight underwent a 5-day high-fat high-calorie (HFHC) dietary intervention. In vivo glucose metabolism was assessed by euglycemic-hyperinsulinemic clamp, glucose tracer and intravenous glucose tolerance test techniques. Body composition was measured by a dual-energy x-ray absorptiometry scan, and plasma RBP4 by an enzyme-linked immunosorbent assay. RBP4 was not associated with birth weight, but with BMI (beta = 0.9 mu g/ml (0.08;1.8) (95% confidence interval), P = 0.03) and plasma levels of low-density lipoprotein cholesterol (beta = 5.3 mu g/ml (1.9;8.7), P = 0.03) and triglycerides (beta = 15.4 mu g/ml (9.5;21.3), P &lt; 0.001). Under baseline diet conditions, RBP4 was associated with decreased disposition index (D-i) (beta = -2.4% (-4.5%;-0.2%), P = 0.04) and increased basal hepatic glucose production rate (HGP) (beta = 0.02 mg kg(-1) min(-1) (0.002;0.04), P = 0.03), but not associated with peripheral glucose disposal rate or hepatic insulin resistance index. RBP4 levels were not influenced by overfeeding or related to peripheral and hepatic insulin resistance provoked by the dietary intervention. In conclusion, plasma RBP4 in young men associates with components of the metabolic syndrome, but is not determined by birth weight and seems not to be involved in short-term high-fat diet-induced insulin resistance.},
  author       = {Ribel-Madsen, Rasmus and Brons, Charlotte and Friedrichsen, Martin and Poulsen, Pernille and Vaag, Allan},
  issn         = {1930-739X},
  language     = {eng},
  number       = {6},
  pages        = {1304--1306},
  publisher    = {Nature Publishing Group},
  series       = {Obesity},
  title        = {Retinol-Binding Protein 4 in Young Men With Low Versus Normal Birth Weight: Physiological Response to Short-Term Overfeeding},
  url          = {http://dx.doi.org/10.1038/oby.2010.311},
  volume       = {19},
  year         = {2011},
}