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Distribution of cortical bone in the femoral neck and hip fracture: A prospective case-control analysis of 143 incident hip fractures; the AGES-REYKJAVIK Study

Johannesdottir, Fjola; Poole, Kenneth E. S.; Reeve, Jonathan; Siggeirsdottir, Kristin; Aspelund, Thor; Mogensen, Brynjolfur; Jonsson, Brynjolfur LU ; Sigurdsson, Sigurdur; Harris, Tamara B. and Gudnason, Vilmundur G., et al. (2011) In Bone 48(6). p.1268-1276
Abstract
In this prospective nested case-control study we analyzed the circumferential differences in estimated cortical thickness (Est CTh) of the mid femoral neck as a risk factor for osteoporotic hip fractures in elderly women and men. Segmental QCT analysis of the mid femoral neck was applied to assess cortical thickness in anatomical quadrants. The superior region of the femoral neck was a stronger predictor for hip fracture than the inferior region, particularly in men. There were significant gender differences in Est CTh measurements in the control group but not in the case group. In multivariable analysis for risk of femoral neck (FN) fracture, Est CTh in the supero-anterior (SA) quadrant was significant in both women and men, and remained... (More)
In this prospective nested case-control study we analyzed the circumferential differences in estimated cortical thickness (Est CTh) of the mid femoral neck as a risk factor for osteoporotic hip fractures in elderly women and men. Segmental QCT analysis of the mid femoral neck was applied to assess cortical thickness in anatomical quadrants. The superior region of the femoral neck was a stronger predictor for hip fracture than the inferior region, particularly in men. There were significant gender differences in Est CTh measurements in the control group but not in the case group. In multivariable analysis for risk of femoral neck (FN) fracture, Est CTh in the supero-anterior (SA) quadrant was significant in both women and men, and remained a significant predictor after adjustment for FN areal BMD (aBMD, dimensions g/cm(2), DXA-like), (p = 0.05 and p<0.0001, respectively). In conclusion, Est CTh in the SA quadrant best discriminated cases (n = 143) from controls (n = 298), especially in men. Cortical thinning superiorly in the hip might be of importance in determining resistance to fracture. (C) 2011 Elsevier Inc. All rights reserved. (Less)
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publication status
published
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keywords
Cortical thickness, Hip fracture, Quantitative computed tomography, Proximal femur, BMD
in
Bone
volume
48
issue
6
pages
1268 - 1276
publisher
Elsevier
external identifiers
  • wos:000290974200007
  • scopus:79955885143
ISSN
1873-2763
DOI
10.1016/j.bone.2011.03.776
language
English
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yes
id
937752ca-78e9-4431-a134-5f2273c36a6e (old id 1986103)
date added to LUP
2011-07-01 09:01:47
date last changed
2017-09-17 06:52:18
@article{937752ca-78e9-4431-a134-5f2273c36a6e,
  abstract     = {In this prospective nested case-control study we analyzed the circumferential differences in estimated cortical thickness (Est CTh) of the mid femoral neck as a risk factor for osteoporotic hip fractures in elderly women and men. Segmental QCT analysis of the mid femoral neck was applied to assess cortical thickness in anatomical quadrants. The superior region of the femoral neck was a stronger predictor for hip fracture than the inferior region, particularly in men. There were significant gender differences in Est CTh measurements in the control group but not in the case group. In multivariable analysis for risk of femoral neck (FN) fracture, Est CTh in the supero-anterior (SA) quadrant was significant in both women and men, and remained a significant predictor after adjustment for FN areal BMD (aBMD, dimensions g/cm(2), DXA-like), (p = 0.05 and p&lt;0.0001, respectively). In conclusion, Est CTh in the SA quadrant best discriminated cases (n = 143) from controls (n = 298), especially in men. Cortical thinning superiorly in the hip might be of importance in determining resistance to fracture. (C) 2011 Elsevier Inc. All rights reserved.},
  author       = {Johannesdottir, Fjola and Poole, Kenneth E. S. and Reeve, Jonathan and Siggeirsdottir, Kristin and Aspelund, Thor and Mogensen, Brynjolfur and Jonsson, Brynjolfur and Sigurdsson, Sigurdur and Harris, Tamara B. and Gudnason, Vilmundur G. and Sigurdsson, Gunnar},
  issn         = {1873-2763},
  keyword      = {Cortical thickness,Hip fracture,Quantitative computed tomography,Proximal femur,BMD},
  language     = {eng},
  number       = {6},
  pages        = {1268--1276},
  publisher    = {Elsevier},
  series       = {Bone},
  title        = {Distribution of cortical bone in the femoral neck and hip fracture: A prospective case-control analysis of 143 incident hip fractures; the AGES-REYKJAVIK Study},
  url          = {http://dx.doi.org/10.1016/j.bone.2011.03.776},
  volume       = {48},
  year         = {2011},
}