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Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study

Crowe, Francesca L.; Roddam, Andrew W.; Key, Timothy J.; Appleby, Paul N.; Overvad, Kim; Jakobsen, Marianne U.; Tjonneland, Anne; Hansen, Louise; Boeing, Heiner and Weikert, Cornelia, et al. (2011) In European Heart Journal 32(10). p.1235-1243
Abstract
Aims A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. Methods and results After an average of 8.4 years of follow-up, there were 1636 deaths from IHD among 313 074 men and women without previous myocardial infarction or stroke from eight European countries. Participants consuming at least eight portions (80 g each) of fruits and vegetables a day had a 22% lower risk of fatal IHD [relative risk (RR) = 0.78, 95%... (More)
Aims A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. Methods and results After an average of 8.4 years of follow-up, there were 1636 deaths from IHD among 313 074 men and women without previous myocardial infarction or stroke from eight European countries. Participants consuming at least eight portions (80 g each) of fruits and vegetables a day had a 22% lower risk of fatal IHD [relative risk (RR) = 0.78, 95% confidence interval (CI): 0.65-0.95] compared with those consuming fewer than three portions a day. After calibration of fruit and vegetable intake to account for differences in dietary assessment between the participating centres, a one portion (80 g) increment in fruit and vegetable intake was associated with a 4% lower risk of fatal IHD (RR = 0.96, 95% CI: 0.92-1.00, P for trend = 0.033). Conclusion Results from this large observational study suggest that a higher intake of fruits and vegetables is associated with a reduced risk of IHD mortality. Whether this association is causal and, if so, the biological mechanism(s) by which fruits and vegetables operate to lower IHD risks remains unclear. (Less)
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publication status
published
subject
keywords
Fruits, Vegetables, Coronary disease, Prospective cohort studies
in
European Heart Journal
volume
32
issue
10
pages
1235 - 1243
publisher
Oxford University Press
external identifiers
  • wos:000290812000015
  • scopus:79957498432
ISSN
1522-9645
DOI
10.1093/eurheartj/ehq465
language
English
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yes
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11185508-5978-43eb-8728-74087c2eeabc (old id 1986382)
date added to LUP
2011-07-01 09:14:08
date last changed
2017-11-19 04:01:29
@article{11185508-5978-43eb-8728-74087c2eeabc,
  abstract     = {Aims A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. Methods and results After an average of 8.4 years of follow-up, there were 1636 deaths from IHD among 313 074 men and women without previous myocardial infarction or stroke from eight European countries. Participants consuming at least eight portions (80 g each) of fruits and vegetables a day had a 22% lower risk of fatal IHD [relative risk (RR) = 0.78, 95% confidence interval (CI): 0.65-0.95] compared with those consuming fewer than three portions a day. After calibration of fruit and vegetable intake to account for differences in dietary assessment between the participating centres, a one portion (80 g) increment in fruit and vegetable intake was associated with a 4% lower risk of fatal IHD (RR = 0.96, 95% CI: 0.92-1.00, P for trend = 0.033). Conclusion Results from this large observational study suggest that a higher intake of fruits and vegetables is associated with a reduced risk of IHD mortality. Whether this association is causal and, if so, the biological mechanism(s) by which fruits and vegetables operate to lower IHD risks remains unclear.},
  author       = {Crowe, Francesca L. and Roddam, Andrew W. and Key, Timothy J. and Appleby, Paul N. and Overvad, Kim and Jakobsen, Marianne U. and Tjonneland, Anne and Hansen, Louise and Boeing, Heiner and Weikert, Cornelia and Linseisen, Jakob and Kaaks, Rudolf and Trichopoulou, Antonia and Misirli, Gesthimani and Lagiou, Pagona and Sacerdote, Carlotta and Pala, Valeria and Palli, Domenico and Tumino, Rosario and Panico, Salvatore and Bueno-de-Mesquita, H. Bas and Boer, Jolanda and van Gils, Carla H. and Beulens, Joline W. J. and Barricarte, Aurelio and Rodriguez, Laudina and Larranaga, Nerea and Sanchez, Maria-Jose and Tormo, Maria-Jose and Buckland, Genevieve and Lund, Eiliv and Hedblad, Bo and Melander, Olle and Jansson, Jan-Hakan and Wennberg, Patrik and Wareham, Nicholas J. and Slimani, Nadia and Romieu, Isabelle and Jenab, Mazda and Danesh, John and Gallo, Valentina and Norat, Teresa and Riboli, Elio},
  issn         = {1522-9645},
  keyword      = {Fruits,Vegetables,Coronary disease,Prospective cohort studies},
  language     = {eng},
  number       = {10},
  pages        = {1235--1243},
  publisher    = {Oxford University Press},
  series       = {European Heart Journal},
  title        = {Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study},
  url          = {http://dx.doi.org/10.1093/eurheartj/ehq465},
  volume       = {32},
  year         = {2011},
}