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Association between plasma leptin and blood pressure in two population-based samples of children and adolescents

Grontved, Anders; Steene-Johannessen, Jostein; Kynde, Iben; Franks, Paul LU ; Helge, Jorn Wulf; Froberg, Karsten; Anderssen, Sigmund A. and Andersen, Lars Bo (2011) In Journal of Hypertension 29(6). p.1093-1100
Abstract
Objectives In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of leptin in the association between body mass index and blood pressure. Methods To examine these aims we used a cross-sectional random sample of children and adolescents from Denmark and Norway (n=1993) who had measures of leptin, anthropometry, blood pressure and other personal and biological risk factors for raised blood pressure available. Results... (More)
Objectives In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of leptin in the association between body mass index and blood pressure. Methods To examine these aims we used a cross-sectional random sample of children and adolescents from Denmark and Norway (n=1993) who had measures of leptin, anthropometry, blood pressure and other personal and biological risk factors for raised blood pressure available. Results Both body mass index and leptin were positively associated with blood pressure (P<0.001). The association with leptin was stronger in pre- and early-pubertal children compared to late-and post-pubertal adolescents (P<0.01 for interaction). The association between leptin and blood pressure was almost completely mediated by body mass index, whereas the association between body mass index and blood pressure was modestly mediated by leptin. Conclusion Leptin was strongly associated with blood pressure, a relationship that to a large extent was mediated by body mass index. Conversely, the association between body mass index and blood pressure was only modestly mediated by leptin. This indicates that the influence of adiposity on blood pressure is also driven by other biological risk factors beyond leptin. Such factors could include insulin, glucose, and triglycerides although residual confounding also could account for the observed relationships. J Hypertens 29:1093-1100 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adiposity, blood pressure, children, leptin
in
Journal of Hypertension
volume
29
issue
6
pages
1093 - 1100
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000290251500011
  • scopus:79955579939
ISSN
1473-5598
DOI
10.1097/HJH.0b013e328346d787
language
English
LU publication?
yes
id
48cff098-5a0d-43f7-b234-4fdd9e2b5495 (old id 1987742)
date added to LUP
2011-07-01 09:25:21
date last changed
2017-01-01 05:23:45
@article{48cff098-5a0d-43f7-b234-4fdd9e2b5495,
  abstract     = {Objectives In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of leptin in the association between body mass index and blood pressure. Methods To examine these aims we used a cross-sectional random sample of children and adolescents from Denmark and Norway (n=1993) who had measures of leptin, anthropometry, blood pressure and other personal and biological risk factors for raised blood pressure available. Results Both body mass index and leptin were positively associated with blood pressure (P&lt;0.001). The association with leptin was stronger in pre- and early-pubertal children compared to late-and post-pubertal adolescents (P&lt;0.01 for interaction). The association between leptin and blood pressure was almost completely mediated by body mass index, whereas the association between body mass index and blood pressure was modestly mediated by leptin. Conclusion Leptin was strongly associated with blood pressure, a relationship that to a large extent was mediated by body mass index. Conversely, the association between body mass index and blood pressure was only modestly mediated by leptin. This indicates that the influence of adiposity on blood pressure is also driven by other biological risk factors beyond leptin. Such factors could include insulin, glucose, and triglycerides although residual confounding also could account for the observed relationships. J Hypertens 29:1093-1100 (C) 2011 Wolters Kluwer Health | Lippincott Williams &amp; Wilkins.},
  author       = {Grontved, Anders and Steene-Johannessen, Jostein and Kynde, Iben and Franks, Paul and Helge, Jorn Wulf and Froberg, Karsten and Anderssen, Sigmund A. and Andersen, Lars Bo},
  issn         = {1473-5598},
  keyword      = {adiposity,blood pressure,children,leptin},
  language     = {eng},
  number       = {6},
  pages        = {1093--1100},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Association between plasma leptin and blood pressure in two population-based samples of children and adolescents},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e328346d787},
  volume       = {29},
  year         = {2011},
}