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SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus

Hanly, J. G.; Urowitz, M. B.; Jackson, D.; Bae, S. C.; Gordon, C.; Wallace, D. J.; Clarke, A.; Bernatsky, S.; Vasudevan, A. and Isenberg, D., et al. (2011) In Annals of the Rheumatic Diseases 70(6). p.961-967
Abstract
Objective To examine change in health-related quality of life in association with clinical outcomes of neuropsychiatric events in systemic lupus erythematosus (SLE). Methods An international study evaluated newly diagnosed SLE patients for neuropsychiatric events attributed to SLE and non-SLE causes. The outcome of events was determined by a physician-completed seven-point scale and compared with patient-completed Short Form 36 (SF-36) health survey questionnaires. Statistical analysis used linear mixed-effects regression models with patient-specific random effects. Results 274 patients (92% female; 68% Caucasian), from a cohort of 1400, had one or more neuropsychiatric event in which the interval between assessments was 12.3+/-2 months.... (More)
Objective To examine change in health-related quality of life in association with clinical outcomes of neuropsychiatric events in systemic lupus erythematosus (SLE). Methods An international study evaluated newly diagnosed SLE patients for neuropsychiatric events attributed to SLE and non-SLE causes. The outcome of events was determined by a physician-completed seven-point scale and compared with patient-completed Short Form 36 (SF-36) health survey questionnaires. Statistical analysis used linear mixed-effects regression models with patient-specific random effects. Results 274 patients (92% female; 68% Caucasian), from a cohort of 1400, had one or more neuropsychiatric event in which the interval between assessments was 12.3+/-2 months. The overall difference in change between visits in mental component summary (MCS) scores of the SF-36 was significant (p<0.0001) following adjustments for gender, ethnicity, centre and previous score. A consistent improvement in neuropsychiatric status (N=295) was associated with an increase in the mean (SD) adjusted MCS score of 3.66 (0.89) in SF-36 scores. Between paired visits when the neuropsychiatric status consistently deteriorated (N=30), the adjusted MCS score decreased by 4.00 (1.96). For the physical component summary scores the corresponding changes were + 1.73 (0.71) and -0.62 (1.58) (p<0.05), respectively. Changes in SF-36 subscales were in the same direction (p<0.05; with the exception of role physical). Sensitivity analyses confirmed these findings. Adjustment for age, education, medications, SLE disease activity, organ damage, disease duration, attribution and characteristics of neuropsychiatric events did not substantially alter the results. Conclusion Changes in SF-36 summary and subscale scores, in particular those related to mental health, are strongly associated with the clinical outcome of neuropsychiatric events in SLE patients. (Less)
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Contribution to journal
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published
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in
Annals of the Rheumatic Diseases
volume
70
issue
6
pages
961 - 967
publisher
British Medical Association
external identifiers
  • wos:000290149900014
  • scopus:79955863506
ISSN
1468-2060
DOI
10.1136/ard.2010.138792
language
English
LU publication?
yes
id
6c0aa646-a9c2-47f1-8afb-a3fb0fff22c3 (old id 1988045)
date added to LUP
2011-07-01 09:18:20
date last changed
2017-09-24 04:02:44
@article{6c0aa646-a9c2-47f1-8afb-a3fb0fff22c3,
  abstract     = {Objective To examine change in health-related quality of life in association with clinical outcomes of neuropsychiatric events in systemic lupus erythematosus (SLE). Methods An international study evaluated newly diagnosed SLE patients for neuropsychiatric events attributed to SLE and non-SLE causes. The outcome of events was determined by a physician-completed seven-point scale and compared with patient-completed Short Form 36 (SF-36) health survey questionnaires. Statistical analysis used linear mixed-effects regression models with patient-specific random effects. Results 274 patients (92% female; 68% Caucasian), from a cohort of 1400, had one or more neuropsychiatric event in which the interval between assessments was 12.3+/-2 months. The overall difference in change between visits in mental component summary (MCS) scores of the SF-36 was significant (p&lt;0.0001) following adjustments for gender, ethnicity, centre and previous score. A consistent improvement in neuropsychiatric status (N=295) was associated with an increase in the mean (SD) adjusted MCS score of 3.66 (0.89) in SF-36 scores. Between paired visits when the neuropsychiatric status consistently deteriorated (N=30), the adjusted MCS score decreased by 4.00 (1.96). For the physical component summary scores the corresponding changes were + 1.73 (0.71) and -0.62 (1.58) (p&lt;0.05), respectively. Changes in SF-36 subscales were in the same direction (p&lt;0.05; with the exception of role physical). Sensitivity analyses confirmed these findings. Adjustment for age, education, medications, SLE disease activity, organ damage, disease duration, attribution and characteristics of neuropsychiatric events did not substantially alter the results. Conclusion Changes in SF-36 summary and subscale scores, in particular those related to mental health, are strongly associated with the clinical outcome of neuropsychiatric events in SLE patients.},
  author       = {Hanly, J. G. and Urowitz, M. B. and Jackson, D. and Bae, S. C. and Gordon, C. and Wallace, D. J. and Clarke, A. and Bernatsky, S. and Vasudevan, A. and Isenberg, D. and Rahman, A. and Sanchez-Guerrero, J. and Romero-Diaz, J. and Merrill, J. T. and Fortin, P. R. and Gladman, D. D. and Bruce, I. N. and Steinsson, K. and Khamashta, M. and Alarcon, G. S. and Fessler, B. and Petri, M. and Manzi, S. and Nived, Ola and Sturfelt, Gunnar and Ramsey-Goldman, R. and Dooley, M. A. and Aranow, C. and Van Vollenhoven, R. and Ramos-Casals, M. and Zoma, A. and Kalunian, K. and Farewell, V.},
  issn         = {1468-2060},
  language     = {eng},
  number       = {6},
  pages        = {961--967},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1136/ard.2010.138792},
  volume       = {70},
  year         = {2011},
}