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Is Increased Thrombin Activation in Patients With Abdominal Aortic Aneurysms Dependent on Area or Volume of Aneurysm Thrombus Mass?

Kölbel, Tilo LU ; Donath, Tobias ; Strandberg, Karin LU ; Flondell-Sité, Despina LU ; Kuhme, Tobias ; Gottsäter, Anders LU and Lindblad, Bengt LU (2010) In Angiology 61(1). p.113-118
Abstract
Objectives: Does thrombin activation seen in patients with abdominal aortic aneurysms (AAA) relate to the thrombus surface area or volume within the aneurysm? Patients and methods: A total of 130 patients with AAA were analyzed regarding levels of the complex between activated protein C-protein C inhibitor (APC-PCI) and AAA morphology. Analysis of APC-PCI complex was made using a sandwich immunofluorometric method. Results: Increased APC-PCI concentrations were seen in patients with AAA (0.44 mu g/L; P < .001 compared with controls). The correlations of APC-PCI values were r = .13, P = .13 for aneurysm size, r = .08, P = .35 for thrombus surface area, and r = .13, P = .14 for thrombus volume. APC-PCI values elevated to 0.45 mu g/L in 10... (More)
Objectives: Does thrombin activation seen in patients with abdominal aortic aneurysms (AAA) relate to the thrombus surface area or volume within the aneurysm? Patients and methods: A total of 130 patients with AAA were analyzed regarding levels of the complex between activated protein C-protein C inhibitor (APC-PCI) and AAA morphology. Analysis of APC-PCI complex was made using a sandwich immunofluorometric method. Results: Increased APC-PCI concentrations were seen in patients with AAA (0.44 mu g/L; P < .001 compared with controls). The correlations of APC-PCI values were r = .13, P = .13 for aneurysm size, r = .08, P = .35 for thrombus surface area, and r = .13, P = .14 for thrombus volume. APC-PCI values elevated to 0.45 mu g/L in 10 patients with AAA having no or very little thrombus mass. Conclusion: Disappointingly, no correlation was found between thrombus surface area or volume and levels of the APC-PCI complex. Mechanisms other than the AAA-sac thrombus must be evaluated as cause of thrombin activation in patients with AAA. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Abdominal aortic aneurysm, Aneurysm thrombus, Coagulation activation, Thrombin activation
in
Angiology
volume
61
issue
1
pages
6 pages
publisher
SAGE Publications
external identifiers
  • wos:000273095600019
  • scopus:73449138761
  • pmid:19625264
ISSN
0003-3197
DOI
10.1177/0003319709335906
language
English
LU publication?
yes
id
19b8abd9-4625-4788-bf9b-45255fb01671 (old id 1535552)
date added to LUP
2016-04-01 14:09:47
date last changed
2025-10-14 13:07:51
@article{19b8abd9-4625-4788-bf9b-45255fb01671,
  abstract     = {{Objectives: Does thrombin activation seen in patients with abdominal aortic aneurysms (AAA) relate to the thrombus surface area or volume within the aneurysm? Patients and methods: A total of 130 patients with AAA were analyzed regarding levels of the complex between activated protein C-protein C inhibitor (APC-PCI) and AAA morphology. Analysis of APC-PCI complex was made using a sandwich immunofluorometric method. Results: Increased APC-PCI concentrations were seen in patients with AAA (0.44 mu g/L; P &lt; .001 compared with controls). The correlations of APC-PCI values were r = .13, P = .13 for aneurysm size, r = .08, P = .35 for thrombus surface area, and r = .13, P = .14 for thrombus volume. APC-PCI values elevated to 0.45 mu g/L in 10 patients with AAA having no or very little thrombus mass. Conclusion: Disappointingly, no correlation was found between thrombus surface area or volume and levels of the APC-PCI complex. Mechanisms other than the AAA-sac thrombus must be evaluated as cause of thrombin activation in patients with AAA.}},
  author       = {{Kölbel, Tilo and Donath, Tobias and Strandberg, Karin and Flondell-Sité, Despina and Kuhme, Tobias and Gottsäter, Anders and Lindblad, Bengt}},
  issn         = {{0003-3197}},
  keywords     = {{Abdominal aortic aneurysm; Aneurysm thrombus; Coagulation activation; Thrombin activation}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{113--118}},
  publisher    = {{SAGE Publications}},
  series       = {{Angiology}},
  title        = {{Is Increased Thrombin Activation in Patients With Abdominal Aortic Aneurysms Dependent on Area or Volume of Aneurysm Thrombus Mass?}},
  url          = {{http://dx.doi.org/10.1177/0003319709335906}},
  doi          = {{10.1177/0003319709335906}},
  volume       = {{61}},
  year         = {{2010}},
}