Serum levels of vitamin D, PTH, calcium and breast cancer risk - a prospective nested case-control study.
(2010) In International Journal of Cancer 127(9). p.2159-2168- Abstract
- Previous studies indicate that calcium and its regulating hormones, i.e. parathyroid hormone (PTH) and vitamin D, might affect breast cancer risk. Evidence also suggests that this relationship could be influenced by menopausal status and BMI. We examined breast cancer risk related to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH and calcium using a nested case-control design within the Malmö Diet and Cancer Study. There were 764 incident breast cancer cases, and 764 controls were selected by incidence density matching, using age as the underlying time scale, matching on calendar time at inclusion, menopausal status and age at inclusion. Using logistic regression analysis, odds ratios (OR) with 95% confidence... (More)
- Previous studies indicate that calcium and its regulating hormones, i.e. parathyroid hormone (PTH) and vitamin D, might affect breast cancer risk. Evidence also suggests that this relationship could be influenced by menopausal status and BMI. We examined breast cancer risk related to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH and calcium using a nested case-control design within the Malmö Diet and Cancer Study. There were 764 incident breast cancer cases, and 764 controls were selected by incidence density matching, using age as the underlying time scale, matching on calendar time at inclusion, menopausal status and age at inclusion. Using logistic regression analysis, odds ratios (OR) with 95% confidence intervals were calculated for breast cancer risk in different quartiles of the analysed factors. All analyses were adjusted for risk factors for breast cancer, and for levels of albumin, creatinine and phosphate. Analyses were repeated stratified for BMI and menopausal status, and for low vs. high levels of 25OHD(3), PTH and calcium. There was a weak, non-significant inverse association between breast cancer risk and 25OHD(3), and the OR for the 2(nd), 3(rd) and 4(th) quartiles, as compared to the first, were 0.84(0.60-1.15), 0.84(0.60-1.17), and 0.93(0.66-1.33). Serum calcium was positively associated with breast cancer in pre-menopausal women (OR for the 4(th) quartile = 3.10:1.33-7.22 and p for quartile trend=0.04), and in women with BMI>25 (OR for the 4(th) quartile=1.94:1.12-3.37 and p for trend<0.01). There was no association between baseline serum PTH and breast cancer risk. (c) 2010 UICC. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1540467
- author
- Almquist, Martin LU ; Bondeson, Anne-Greth LU ; Bondeson, Lennart LU ; Malm, Johan LU and Manjer, Jonas LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- calcium, BMI, parathyroid hormone, breast cancer, vitamin D
- in
- International Journal of Cancer
- volume
- 127
- issue
- 9
- pages
- 2159 - 2168
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000282539600017
- pmid:20112341
- scopus:77956641349
- pmid:20112341
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.25215
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology (Malmö) (013031000), Clinical Chemistry, Malmö (013016000), Surgery Research Unit (013242220), Emergency medicine/Medicine/Surgery (013240200)
- id
- 1a067928-d9cc-44d6-8609-3a02ce1ea49d (old id 1540467)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20112341?dopt=Abstract
- date added to LUP
- 2016-04-01 09:50:08
- date last changed
- 2022-05-17 17:22:13
@article{1a067928-d9cc-44d6-8609-3a02ce1ea49d,
abstract = {{Previous studies indicate that calcium and its regulating hormones, i.e. parathyroid hormone (PTH) and vitamin D, might affect breast cancer risk. Evidence also suggests that this relationship could be influenced by menopausal status and BMI. We examined breast cancer risk related to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH and calcium using a nested case-control design within the Malmö Diet and Cancer Study. There were 764 incident breast cancer cases, and 764 controls were selected by incidence density matching, using age as the underlying time scale, matching on calendar time at inclusion, menopausal status and age at inclusion. Using logistic regression analysis, odds ratios (OR) with 95% confidence intervals were calculated for breast cancer risk in different quartiles of the analysed factors. All analyses were adjusted for risk factors for breast cancer, and for levels of albumin, creatinine and phosphate. Analyses were repeated stratified for BMI and menopausal status, and for low vs. high levels of 25OHD(3), PTH and calcium. There was a weak, non-significant inverse association between breast cancer risk and 25OHD(3), and the OR for the 2(nd), 3(rd) and 4(th) quartiles, as compared to the first, were 0.84(0.60-1.15), 0.84(0.60-1.17), and 0.93(0.66-1.33). Serum calcium was positively associated with breast cancer in pre-menopausal women (OR for the 4(th) quartile = 3.10:1.33-7.22 and p for quartile trend=0.04), and in women with BMI>25 (OR for the 4(th) quartile=1.94:1.12-3.37 and p for trend<0.01). There was no association between baseline serum PTH and breast cancer risk. (c) 2010 UICC.}},
author = {{Almquist, Martin and Bondeson, Anne-Greth and Bondeson, Lennart and Malm, Johan and Manjer, Jonas}},
issn = {{0020-7136}},
keywords = {{calcium; BMI; parathyroid hormone; breast cancer; vitamin D}},
language = {{eng}},
number = {{9}},
pages = {{2159--2168}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Serum levels of vitamin D, PTH, calcium and breast cancer risk - a prospective nested case-control study.}},
url = {{http://dx.doi.org/10.1002/ijc.25215}},
doi = {{10.1002/ijc.25215}},
volume = {{127}},
year = {{2010}},
}