Multi-molecular imaging showing tumour heterogeneity and differing diagnostic performance in a case with metastatic pheochromocytoma
(2025) In EJNMMI reports 9(1).- Abstract
A patient with multiple endocrine neoplasia 2A (MEN2A) and a suspicion of metastasized pheochromocytoma, underwent multi-molecular positron emission tomography (PET) imaging with the recently presented radiopharmaceutical [18F]-metafluorobenzylguanidine (mFBG), [68Ga]Ga-DOTA-TOC and [18F]F-dihydroxyphenylalanine (DOPA) as well as scintigraphy with [123I]-metaiodobenzylguanidine (mIBG). The methods showed different diagnostic performance, with the highest number of suspected malignant lesions detected by [18F]-mFBG-PET, and revealed insights into tumour heterogeneity.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1a0f7390-82ad-4197-84f5-2dd347d035e3
- author
- Hedeer, Fredrik LU ; Oddstig, Jenny LU ; Hallgrimson, Páll and Fagher, Katarina LU
- organization
- publishing date
- 2025-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- I-mIBG, F-DOPA, F-mFBG, Ga-DOTA-TOC, Molecular imaging, Neuroendocrine tumour, Paraganglioma, PET, Pheochromocytoma, Scintigraphy
- in
- EJNMMI reports
- volume
- 9
- issue
- 1
- article number
- 31
- publisher
- Springer Nature
- external identifiers
-
- pmid:40887494
- scopus:105014883253
- ISSN
- 3005-074X
- DOI
- 10.1186/s41824-025-00267-3
- language
- English
- LU publication?
- yes
- id
- 1a0f7390-82ad-4197-84f5-2dd347d035e3
- date added to LUP
- 2025-10-02 15:29:22
- date last changed
- 2025-10-16 17:24:15
@article{1a0f7390-82ad-4197-84f5-2dd347d035e3,
abstract = {{<p>A patient with multiple endocrine neoplasia 2A (MEN2A) and a suspicion of metastasized pheochromocytoma, underwent multi-molecular positron emission tomography (PET) imaging with the recently presented radiopharmaceutical [<sup>18</sup>F]-metafluorobenzylguanidine (mFBG), [<sup>68</sup>Ga]Ga-DOTA-TOC and [<sup>18</sup>F]F-dihydroxyphenylalanine (DOPA) as well as scintigraphy with [<sup>123</sup>I]-metaiodobenzylguanidine (mIBG). The methods showed different diagnostic performance, with the highest number of suspected malignant lesions detected by [<sup>18</sup>F]-mFBG-PET, and revealed insights into tumour heterogeneity.</p>}},
author = {{Hedeer, Fredrik and Oddstig, Jenny and Hallgrimson, Páll and Fagher, Katarina}},
issn = {{3005-074X}},
keywords = {{I-mIBG; F-DOPA; F-mFBG; Ga-DOTA-TOC; Molecular imaging; Neuroendocrine tumour; Paraganglioma; PET; Pheochromocytoma; Scintigraphy}},
language = {{eng}},
number = {{1}},
publisher = {{Springer Nature}},
series = {{EJNMMI reports}},
title = {{Multi-molecular imaging showing tumour heterogeneity and differing diagnostic performance in a case with metastatic pheochromocytoma}},
url = {{http://dx.doi.org/10.1186/s41824-025-00267-3}},
doi = {{10.1186/s41824-025-00267-3}},
volume = {{9}},
year = {{2025}},
}