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Multi-molecular imaging showing tumour heterogeneity and differing diagnostic performance in a case with metastatic pheochromocytoma

Hedeer, Fredrik LU ; Oddstig, Jenny LU ; Hallgrimson, Páll and Fagher, Katarina LU (2025) In EJNMMI reports 9(1).
Abstract

A patient with multiple endocrine neoplasia 2A (MEN2A) and a suspicion of metastasized pheochromocytoma, underwent multi-molecular positron emission tomography (PET) imaging with the recently presented radiopharmaceutical [18F]-metafluorobenzylguanidine (mFBG), [68Ga]Ga-DOTA-TOC and [18F]F-dihydroxyphenylalanine (DOPA) as well as scintigraphy with [123I]-metaiodobenzylguanidine (mIBG). The methods showed different diagnostic performance, with the highest number of suspected malignant lesions detected by [18F]-mFBG-PET, and revealed insights into tumour heterogeneity.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
I-mIBG, F-DOPA, F-mFBG, Ga-DOTA-TOC, Molecular imaging, Neuroendocrine tumour, Paraganglioma, PET, Pheochromocytoma, Scintigraphy
in
EJNMMI reports
volume
9
issue
1
article number
31
publisher
Springer Nature
external identifiers
  • pmid:40887494
  • scopus:105014883253
ISSN
3005-074X
DOI
10.1186/s41824-025-00267-3
language
English
LU publication?
yes
id
1a0f7390-82ad-4197-84f5-2dd347d035e3
date added to LUP
2025-10-02 15:29:22
date last changed
2025-10-16 17:24:15
@article{1a0f7390-82ad-4197-84f5-2dd347d035e3,
  abstract     = {{<p>A patient with multiple endocrine neoplasia 2A (MEN2A) and a suspicion of metastasized pheochromocytoma, underwent multi-molecular positron emission tomography (PET) imaging with the recently presented radiopharmaceutical [<sup>18</sup>F]-metafluorobenzylguanidine (mFBG), [<sup>68</sup>Ga]Ga-DOTA-TOC and [<sup>18</sup>F]F-dihydroxyphenylalanine (DOPA) as well as scintigraphy with [<sup>123</sup>I]-metaiodobenzylguanidine (mIBG). The methods showed different diagnostic performance, with the highest number of suspected malignant lesions detected by [<sup>18</sup>F]-mFBG-PET, and revealed insights into tumour heterogeneity.</p>}},
  author       = {{Hedeer, Fredrik and Oddstig, Jenny and Hallgrimson, Páll and Fagher, Katarina}},
  issn         = {{3005-074X}},
  keywords     = {{I-mIBG; F-DOPA; F-mFBG; Ga-DOTA-TOC; Molecular imaging; Neuroendocrine tumour; Paraganglioma; PET; Pheochromocytoma; Scintigraphy}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Springer Nature}},
  series       = {{EJNMMI reports}},
  title        = {{Multi-molecular imaging showing tumour heterogeneity and differing diagnostic performance in a case with metastatic pheochromocytoma}},
  url          = {{http://dx.doi.org/10.1186/s41824-025-00267-3}},
  doi          = {{10.1186/s41824-025-00267-3}},
  volume       = {{9}},
  year         = {{2025}},
}