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Sensitization to Skin-associated Microorganisms in Adult Patients with Atopic Dermatitis is of Importance for Disease Severity.

Sonesson, Andreas LU ; Bartosik, Jacek LU ; Christiansen, Julie; Roscher, Ingrid; Nilsson, Fredrik; Schmidtchen, Artur LU and Bäck, Ove LU (2013) In Acta Dermato-Venereologica 93(3). p.340-345
Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Environmental and genetic factors, as well as microbial products from yeasts and bacteria, play a role in triggering the disease. A cohort of 619 adult patients with AD was screened for severity of AD, sensitization to Malassezia sympodialis, Candida albicans, Staphylococcus aureus enterotoxins and Dermatophagoides pteronyssinus. Serum levels of interleukin (IL)-18 were measured. Immunoglobulin E (IgE) sensitization to the combination of both yeast and mite antigens was found to be associated with more severe disease and higher levels of total IgE. AD patients with IgE sensitization to several microbial antigens had more severe disease than those with no IgE sensitization to... (More)
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Environmental and genetic factors, as well as microbial products from yeasts and bacteria, play a role in triggering the disease. A cohort of 619 adult patients with AD was screened for severity of AD, sensitization to Malassezia sympodialis, Candida albicans, Staphylococcus aureus enterotoxins and Dermatophagoides pteronyssinus. Serum levels of interleukin (IL)-18 were measured. Immunoglobulin E (IgE) sensitization to the combination of both yeast and mite antigens was found to be associated with more severe disease and higher levels of total IgE. AD patients with IgE sensitization to several microbial antigens had more severe disease than those with no IgE sensitization to microbial antigens. Sera from patients with IgE-associated AD showed higher levels of IL-18. Skin-associated microorganisms are exogenous factors triggering IgE-response and severity of AD. These findings are clinically important, and sensitization to these organisms should be assessed and considered in treatment strategies. (Less)
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type
Contribution to journal
publication status
published
subject
in
Acta Dermato-Venereologica
volume
93
issue
3
pages
340 - 345
publisher
Medical Journals Limited
external identifiers
  • wos:000320343800017
  • pmid:23073977
  • scopus:84876998788
ISSN
1651-2057
DOI
10.2340/00015555-1465
language
English
LU publication?
yes
id
1a340db6-ca6d-455a-853c-e88e6a50666e (old id 3160617)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23073977?dopt=Abstract
date added to LUP
2012-11-01 13:19:31
date last changed
2019-08-28 01:00:23
@article{1a340db6-ca6d-455a-853c-e88e6a50666e,
  abstract     = {Atopic dermatitis (AD) is a chronic inflammatory skin disease. Environmental and genetic factors, as well as microbial products from yeasts and bacteria, play a role in triggering the disease. A cohort of 619 adult patients with AD was screened for severity of AD, sensitization to Malassezia sympodialis, Candida albicans, Staphylococcus aureus enterotoxins and Dermatophagoides pteronyssinus. Serum levels of interleukin (IL)-18 were measured. Immunoglobulin E (IgE) sensitization to the combination of both yeast and mite antigens was found to be associated with more severe disease and higher levels of total IgE. AD patients with IgE sensitization to several microbial antigens had more severe disease than those with no IgE sensitization to microbial antigens. Sera from patients with IgE-associated AD showed higher levels of IL-18. Skin-associated microorganisms are exogenous factors triggering IgE-response and severity of AD. These findings are clinically important, and sensitization to these organisms should be assessed and considered in treatment strategies.},
  author       = {Sonesson, Andreas and Bartosik, Jacek and Christiansen, Julie and Roscher, Ingrid and Nilsson, Fredrik and Schmidtchen, Artur and Bäck, Ove},
  issn         = {1651-2057},
  language     = {eng},
  number       = {3},
  pages        = {340--345},
  publisher    = {Medical Journals Limited},
  series       = {Acta Dermato-Venereologica},
  title        = {Sensitization to Skin-associated Microorganisms in Adult Patients with Atopic Dermatitis is of Importance for Disease Severity.},
  url          = {http://dx.doi.org/10.2340/00015555-1465},
  volume       = {93},
  year         = {2013},
}