Sensitization to Skin-associated Microorganisms in Adult Patients with Atopic Dermatitis is of Importance for Disease Severity.
(2013) In Acta Dermato-Venereologica 93(3). p.340-345- Abstract
- Atopic dermatitis (AD) is a chronic inflammatory skin disease. Environmental and genetic factors, as well as microbial products from yeasts and bacteria, play a role in triggering the disease. A cohort of 619 adult patients with AD was screened for severity of AD, sensitization to Malassezia sympodialis, Candida albicans, Staphylococcus aureus enterotoxins and Dermatophagoides pteronyssinus. Serum levels of interleukin (IL)-18 were measured. Immunoglobulin E (IgE) sensitization to the combination of both yeast and mite antigens was found to be associated with more severe disease and higher levels of total IgE. AD patients with IgE sensitization to several microbial antigens had more severe disease than those with no IgE sensitization to... (More)
- Atopic dermatitis (AD) is a chronic inflammatory skin disease. Environmental and genetic factors, as well as microbial products from yeasts and bacteria, play a role in triggering the disease. A cohort of 619 adult patients with AD was screened for severity of AD, sensitization to Malassezia sympodialis, Candida albicans, Staphylococcus aureus enterotoxins and Dermatophagoides pteronyssinus. Serum levels of interleukin (IL)-18 were measured. Immunoglobulin E (IgE) sensitization to the combination of both yeast and mite antigens was found to be associated with more severe disease and higher levels of total IgE. AD patients with IgE sensitization to several microbial antigens had more severe disease than those with no IgE sensitization to microbial antigens. Sera from patients with IgE-associated AD showed higher levels of IL-18. Skin-associated microorganisms are exogenous factors triggering IgE-response and severity of AD. These findings are clinically important, and sensitization to these organisms should be assessed and considered in treatment strategies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3160617
- author
- Sonesson, Andreas LU ; Bartosik, Jacek LU ; Christiansen, Julie ; Roscher, Ingrid ; Nilsson, Fredrik ; Schmidtchen, Artur LU and Bäck, Ove LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Dermato-Venereologica
- volume
- 93
- issue
- 3
- pages
- 340 - 345
- publisher
- Medical Journals Limited
- external identifiers
-
- wos:000320343800017
- pmid:23073977
- scopus:84876998788
- pmid:23073977
- ISSN
- 1651-2057
- DOI
- 10.2340/00015555-1465
- language
- English
- LU publication?
- yes
- id
- 1a340db6-ca6d-455a-853c-e88e6a50666e (old id 3160617)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23073977?dopt=Abstract
- date added to LUP
- 2016-04-01 09:48:47
- date last changed
- 2022-03-04 05:13:39
@article{1a340db6-ca6d-455a-853c-e88e6a50666e, abstract = {{Atopic dermatitis (AD) is a chronic inflammatory skin disease. Environmental and genetic factors, as well as microbial products from yeasts and bacteria, play a role in triggering the disease. A cohort of 619 adult patients with AD was screened for severity of AD, sensitization to Malassezia sympodialis, Candida albicans, Staphylococcus aureus enterotoxins and Dermatophagoides pteronyssinus. Serum levels of interleukin (IL)-18 were measured. Immunoglobulin E (IgE) sensitization to the combination of both yeast and mite antigens was found to be associated with more severe disease and higher levels of total IgE. AD patients with IgE sensitization to several microbial antigens had more severe disease than those with no IgE sensitization to microbial antigens. Sera from patients with IgE-associated AD showed higher levels of IL-18. Skin-associated microorganisms are exogenous factors triggering IgE-response and severity of AD. These findings are clinically important, and sensitization to these organisms should be assessed and considered in treatment strategies.}}, author = {{Sonesson, Andreas and Bartosik, Jacek and Christiansen, Julie and Roscher, Ingrid and Nilsson, Fredrik and Schmidtchen, Artur and Bäck, Ove}}, issn = {{1651-2057}}, language = {{eng}}, number = {{3}}, pages = {{340--345}}, publisher = {{Medical Journals Limited}}, series = {{Acta Dermato-Venereologica}}, title = {{Sensitization to Skin-associated Microorganisms in Adult Patients with Atopic Dermatitis is of Importance for Disease Severity.}}, url = {{https://lup.lub.lu.se/search/files/1273978/3165442.pdf}}, doi = {{10.2340/00015555-1465}}, volume = {{93}}, year = {{2013}}, }