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External Validation of Pre-Treatment Primary Tumor Volume as a Prognostic Factor in Head and Neck Cancer Treated With (Chemo)Radiotherapy

Adrian, Gabriel LU orcid ; Änghede, Andre Haraldsson ; McDowell, Lachlan and Gebre-Medhin, Maria LU (2026) In Head and Neck
Abstract

Background: Primary tumor volume (GTVp) is a key prognostic factor in oropharyngeal squamous cell carcinoma (OPSCC) treated with radiotherapy. We aimed to externally validate this association and assess its relevance in other head and neck sites. Methods: Patients from the RADCURE dataset were analyzed using Cox regression for local failure, progression-free survival (PFS), and overall survival (OS). Subgroup analyses included HPV status, chemotherapy use, and separate evaluations for hypopharyngeal and laryngeal cancers. Model performance was assessed using the concordance index (C-index). Results: Among 1286 OPSCC patients, increasing GTVp was associated with a higher risk of local failure and reduced PFS and OS, consistent across HPV... (More)

Background: Primary tumor volume (GTVp) is a key prognostic factor in oropharyngeal squamous cell carcinoma (OPSCC) treated with radiotherapy. We aimed to externally validate this association and assess its relevance in other head and neck sites. Methods: Patients from the RADCURE dataset were analyzed using Cox regression for local failure, progression-free survival (PFS), and overall survival (OS). Subgroup analyses included HPV status, chemotherapy use, and separate evaluations for hypopharyngeal and laryngeal cancers. Model performance was assessed using the concordance index (C-index). Results: Among 1286 OPSCC patients, increasing GTVp was associated with a higher risk of local failure and reduced PFS and OS, consistent across HPV and chemotherapy subgroups. Similar associations were observed in hypopharyngeal (n = 157) and laryngeal (n = 803) cancers. Model performance was strong (C-index up to 0.82). Conclusion: Primary tumor volume is a robust prognostic factor across head and neck cancer sites, supporting risk stratification in curative radiotherapy.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
hypopharynx cancer, larynx cancer, oropharyngeal squamous cell carcinoma, prognostic factor, tumor volume, validation
in
Head and Neck
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:105038563300
  • pmid:42115128
ISSN
1043-3074
DOI
10.1002/hed.70315
language
English
LU publication?
yes
id
1a3b7845-4638-48ce-b8fd-56bd32536c5f
date added to LUP
2026-07-07 15:14:17
date last changed
2026-07-08 03:00:03
@article{1a3b7845-4638-48ce-b8fd-56bd32536c5f,
  abstract     = {{<p>Background: Primary tumor volume (GTVp) is a key prognostic factor in oropharyngeal squamous cell carcinoma (OPSCC) treated with radiotherapy. We aimed to externally validate this association and assess its relevance in other head and neck sites. Methods: Patients from the RADCURE dataset were analyzed using Cox regression for local failure, progression-free survival (PFS), and overall survival (OS). Subgroup analyses included HPV status, chemotherapy use, and separate evaluations for hypopharyngeal and laryngeal cancers. Model performance was assessed using the concordance index (C-index). Results: Among 1286 OPSCC patients, increasing GTVp was associated with a higher risk of local failure and reduced PFS and OS, consistent across HPV and chemotherapy subgroups. Similar associations were observed in hypopharyngeal (n = 157) and laryngeal (n = 803) cancers. Model performance was strong (C-index up to 0.82). Conclusion: Primary tumor volume is a robust prognostic factor across head and neck cancer sites, supporting risk stratification in curative radiotherapy.</p>}},
  author       = {{Adrian, Gabriel and Änghede, Andre Haraldsson and McDowell, Lachlan and Gebre-Medhin, Maria}},
  issn         = {{1043-3074}},
  keywords     = {{hypopharynx cancer; larynx cancer; oropharyngeal squamous cell carcinoma; prognostic factor; tumor volume; validation}},
  language     = {{eng}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Head and Neck}},
  title        = {{External Validation of Pre-Treatment Primary Tumor Volume as a Prognostic Factor in Head and Neck Cancer Treated With (Chemo)Radiotherapy}},
  url          = {{http://dx.doi.org/10.1002/hed.70315}},
  doi          = {{10.1002/hed.70315}},
  year         = {{2026}},
}