Does a childhood fracture predict low bone mass in young adulthood? - A 27-year prospective controlled study.
(2013) In Journal of Bone and Mineral Research 28(2). p.351-359- Abstract
- BACKGROUND:
A fracture in childhood is associated with low bone mineral density (BMD), but it is debated whether a fracture at growth also predicts low BMD in young adulthood. PURPOSE: To gender-specifically evaluate whether children with a fracture are at increased risk of low BMD in young adulthood.
METHODS:
Distal forearm BMD (g/cm(2) ) was measured with single photon absorptiometry (SPA) in 47 boys and 26 girls (mean age 10 years, range 3-16) with an index fracture and in 41 boys and 43 girls (mean age 10 years, range 4-16) with no fracture. BMD was re-measured mean 27 years later with the same SPA apparatus and with dual energy absorptiometry (DXA), quantitative ultrasound (QUS) and peripheral... (More) - BACKGROUND:
A fracture in childhood is associated with low bone mineral density (BMD), but it is debated whether a fracture at growth also predicts low BMD in young adulthood. PURPOSE: To gender-specifically evaluate whether children with a fracture are at increased risk of low BMD in young adulthood.
METHODS:
Distal forearm BMD (g/cm(2) ) was measured with single photon absorptiometry (SPA) in 47 boys and 26 girls (mean age 10 years, range 3-16) with an index fracture and in 41 boys and 43 girls (mean age 10 years, range 4-16) with no fracture. BMD was re-measured mean 27 years later with the same SPA apparatus and with dual energy absorptiometry (DXA), quantitative ultrasound (QUS) and peripheral computed tomography (pQCT). Individual Z-scores were calculated using the control cohort as reference population. Data are presented as means with 95% confidence intervals (95% CI) within brackets and correlation with Pearson's correlation coefficient
RESULTS:
Boys with an index fracture had at fracture event a distal forearm BMD Z-score of -0.4 (-0.7, -0.1) and at follow-up -0.4 (-0.7, -0.1). Corresponding values in girls were -0.2 (-0.5, 0.1) and -0.3 (-0.7, 0.1). The deficit in absolute bone mass was driven by men with index fractures in childhood due to low rather than moderate or high energy. There were no changes in BMD Z-score during the follow-up period. The BMD deficit at follow-up was in boys with an index fracture verified with all advocated techniques
CONCLUSIONS:
A childhood fracture in men was associated with low BMD and smaller bone size in young adulthood while the deficit in women did not reach statistical significance. © 2012 American Society for Bone and Mineral Research. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3047289
- author
- Buttazzoni, Christian LU ; Rosengren, E LU ; Tveit, Magnus LU ; Landin, Lennart LU ; Nilsson, J-Å LU and Karlsson, K M LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Bone and Mineral Research
- volume
- 28
- issue
- 2
- pages
- 351 - 359
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000315105600014
- pmid:22915380
- scopus:84872447957
- pmid:22915380
- ISSN
- 1523-4681
- DOI
- 10.1002/jbmr.1743
- language
- English
- LU publication?
- yes
- id
- 1a4d7116-7a15-42d4-96d0-86466e525639 (old id 3047289)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22915380?dopt=Abstract
- date added to LUP
- 2016-04-01 10:47:14
- date last changed
- 2024-02-22 10:58:35
@article{1a4d7116-7a15-42d4-96d0-86466e525639, abstract = {{BACKGROUND: <br/><br> A fracture in childhood is associated with low bone mineral density (BMD), but it is debated whether a fracture at growth also predicts low BMD in young adulthood. PURPOSE: To gender-specifically evaluate whether children with a fracture are at increased risk of low BMD in young adulthood. <br/><br> <br/><br> METHODS: <br/><br> Distal forearm BMD (g/cm(2) ) was measured with single photon absorptiometry (SPA) in 47 boys and 26 girls (mean age 10 years, range 3-16) with an index fracture and in 41 boys and 43 girls (mean age 10 years, range 4-16) with no fracture. BMD was re-measured mean 27 years later with the same SPA apparatus and with dual energy absorptiometry (DXA), quantitative ultrasound (QUS) and peripheral computed tomography (pQCT). Individual Z-scores were calculated using the control cohort as reference population. Data are presented as means with 95% confidence intervals (95% CI) within brackets and correlation with Pearson's correlation coefficient <br/><br> <br/><br> RESULTS: <br/><br> Boys with an index fracture had at fracture event a distal forearm BMD Z-score of -0.4 (-0.7, -0.1) and at follow-up -0.4 (-0.7, -0.1). Corresponding values in girls were -0.2 (-0.5, 0.1) and -0.3 (-0.7, 0.1). The deficit in absolute bone mass was driven by men with index fractures in childhood due to low rather than moderate or high energy. There were no changes in BMD Z-score during the follow-up period. The BMD deficit at follow-up was in boys with an index fracture verified with all advocated techniques <br/><br> <br/><br> CONCLUSIONS: <br/><br> A childhood fracture in men was associated with low BMD and smaller bone size in young adulthood while the deficit in women did not reach statistical significance. © 2012 American Society for Bone and Mineral Research.}}, author = {{Buttazzoni, Christian and Rosengren, E and Tveit, Magnus and Landin, Lennart and Nilsson, J-Å and Karlsson, K M}}, issn = {{1523-4681}}, language = {{eng}}, number = {{2}}, pages = {{351--359}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Bone and Mineral Research}}, title = {{Does a childhood fracture predict low bone mass in young adulthood? - A 27-year prospective controlled study.}}, url = {{http://dx.doi.org/10.1002/jbmr.1743}}, doi = {{10.1002/jbmr.1743}}, volume = {{28}}, year = {{2013}}, }