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A mixed endocrine adrenal tumour causing steatorrhoea

Thesleff, P ; Benoni, C LU ; Mårtensson, H ; Nilsson, A LU ; Sundler, F and Akesson, B LU (1987) In Gut 28(10). p.301-1298
Abstract

A 60 year old man developed steatorrhoea, weight loss, mild diabetes mellitus, labile hypertension and limb cramps. Raised plasma concentrations of catecholamines, particularly noradrenaline and a computed tomography-scan showing an adrenal tumour strongly suggested a pheochromocytoma. Adrenoreceptor blockade reversed the symptoms, decreased faecal fat, and increased duodenal trypsin to normal concentrations. After adrenalectomy the patient was asymptomatic and there was no steatorrhoea. The blood glucose concentrations became normal. Immunocytochemistry revealed the tumour cells to store large amounts of enkephalin and somatostatin reactive material and moderate amounts of immunoreactive beta-endorphin and dynorphin.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adrenal Gland Neoplasms/complications, Celiac Disease/etiology, Endorphins/metabolism, Humans, Male, Middle Aged, Norepinephrine/metabolism, Pheochromocytoma/complications, Somatostatin/metabolism
in
Gut
volume
28
issue
10
pages
4 pages
publisher
BMJ Publishing Group
external identifiers
  • scopus:0023232158
  • pmid:2890560
ISSN
0017-5749
DOI
10.1136/gut.28.10.1298
language
English
LU publication?
yes
id
1a7347bd-a484-45b4-b72d-d7ec3061d066
date added to LUP
2019-09-24 15:10:48
date last changed
2020-01-13 02:25:14
@article{1a7347bd-a484-45b4-b72d-d7ec3061d066,
  abstract     = {<p>A 60 year old man developed steatorrhoea, weight loss, mild diabetes mellitus, labile hypertension and limb cramps. Raised plasma concentrations of catecholamines, particularly noradrenaline and a computed tomography-scan showing an adrenal tumour strongly suggested a pheochromocytoma. Adrenoreceptor blockade reversed the symptoms, decreased faecal fat, and increased duodenal trypsin to normal concentrations. After adrenalectomy the patient was asymptomatic and there was no steatorrhoea. The blood glucose concentrations became normal. Immunocytochemistry revealed the tumour cells to store large amounts of enkephalin and somatostatin reactive material and moderate amounts of immunoreactive beta-endorphin and dynorphin.</p>},
  author       = {Thesleff, P and Benoni, C and Mårtensson, H and Nilsson, A and Sundler, F and Akesson, B},
  issn         = {0017-5749},
  language     = {eng},
  number       = {10},
  pages        = {301--1298},
  publisher    = {BMJ Publishing Group},
  series       = {Gut},
  title        = {A mixed endocrine adrenal tumour causing steatorrhoea},
  url          = {http://dx.doi.org/10.1136/gut.28.10.1298},
  doi          = {10.1136/gut.28.10.1298},
  volume       = {28},
  year         = {1987},
}