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Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition

Bradbury, Kathryn E.; Appleby, Paul N.; Tipper, Sarah J.; Travis, Ruth C.; Allen, Naomi E.; Kvaskoff, Marina; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte and Cervenka, Iris, et al. (2019) In International Journal of Cancer 144(5). p.957-966
Abstract

Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case–control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for... (More)

Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case–control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.

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published
subject
keywords
biomarker, EPIC, height, insulin-like growth factor I, melanoma, prospective studies
in
International Journal of Cancer
volume
144
issue
5
pages
957 - 966
publisher
John Wiley & Sons
external identifiers
  • scopus:85058172286
ISSN
0020-7136
DOI
10.1002/ijc.31854
language
English
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yes
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1a84dea4-099f-4f3c-8537-60ce9bbb9c3b
date added to LUP
2019-01-08 15:09:49
date last changed
2019-01-09 03:00:05
@article{1a84dea4-099f-4f3c-8537-60ce9bbb9c3b,
  abstract     = {<p>Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case–control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.</p>},
  author       = {Bradbury, Kathryn E. and Appleby, Paul N. and Tipper, Sarah J. and Travis, Ruth C. and Allen, Naomi E. and Kvaskoff, Marina and Overvad, Kim and Tjønneland, Anne and Halkjær, Jytte and Cervenka, Iris and Mahamat-Saleh, Yahya and Bonnet, Fabrice and Kaaks, Rudolf and Fortner, Renée T. and Boeing, Heiner and Trichopoulou, Antonia and La Vecchia, Carlo and Stratigos, Alexander J. and Palli, Domenico and Grioni, Sara and Matullo, Giuseppe and Panico, Salvatore and Tumino, Rosario and Peeters, Petra H. and Bueno-de-Mesquita, H. Bas and Ghiasvand, Reza and Veierød, Marit B. and Weiderpass, Elisabete and Bonet, Catalina and Molina, Elena and Huerta, José M. and Larrañaga, Nerea and Barricarte, Aurelio and Merino, Susana and Isaksson, Karolin and Stocks, Tanja and Ljuslinder, Ingrid and Hemmingsson, Oskar and Wareham, Nick and Khaw, Kay Tee and Gunter, Marc J. and Rinaldi, Sabina and Tsilidis, Konstantinos K. and Aune, Dagfinn and Riboli, Elio and Key, Timothy J.},
  issn         = {0020-7136},
  keyword      = {biomarker,EPIC,height,insulin-like growth factor I,melanoma,prospective studies},
  language     = {eng},
  number       = {5},
  pages        = {957--966},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.31854},
  volume       = {144},
  year         = {2019},
}