Predominance of girls with cancer in families with multiple childhood cancer cases
(2017) In BMC Cancer 17(1).- Abstract
Background: Recent studies indicate that one of four childhood cancers can be attributed to hereditary genetic abnormalities. Methods: The Lund Childhood Cancer Genetic study includes newly diagnosed childhood cancer patients as well as childhood cancer survivors visiting the Department of Pediatrics or the Late Effect Clinic at Skåne University Hospital, Lund, Sweden. Questionnaires regarding family history of cancer and blood samples were provided. Reported data were validated and extended by use of the Swedish Population- and Cancer Registries. Demographics in families with one case of childhood cancer (FAM1) were investigated and compared to families with multiple cases of childhood cancer (FAM > 1) as well as to childhood cancer... (More)
Background: Recent studies indicate that one of four childhood cancers can be attributed to hereditary genetic abnormalities. Methods: The Lund Childhood Cancer Genetic study includes newly diagnosed childhood cancer patients as well as childhood cancer survivors visiting the Department of Pediatrics or the Late Effect Clinic at Skåne University Hospital, Lund, Sweden. Questionnaires regarding family history of cancer and blood samples were provided. Reported data were validated and extended by use of the Swedish Population- and Cancer Registries. Demographics in families with one case of childhood cancer (FAM1) were investigated and compared to families with multiple cases of childhood cancer (FAM > 1) as well as to childhood cancer in the general population. Results: Forty-one out of 528 families (7.8%) had more than one case of childhood cancer. In 23 families the affected children were relatives up to a 3rd degree (4.4%). In FAM > 1, 69.2% of the children with leukemia and 60% of those with tumors in the central nervous system (CNS) had a childhood relative with matching diagnosis, both significantly higher than expected. Significantly more female than male patients were observed in FAM > 1 compared to FAM1. This female predominance was most striking in childhood leukemia (77% female) and also, yet to a lesser extent, in CNS tumors (68% female). Conclusions: We conclude that the high proportion of children with leukemia or CNS tumors in FAM > 1 having a childhood relative with the same diagnosis suggests a hereditary background. Moreover, we report a female predominance in childhood leukemia and childhood CNS tumors in FAM > 1, which may indicate a hereditary gender-specific risk factor in these families.
(Less)
- author
- Stjernfelt, Karl Johan
LU
; von Stedingk, Kristoffer
LU
; Wiebe, Thomas
LU
; Hjorth, Lars
LU
; Olsson, Håkan
LU
and Øra, Ingrid LU
- organization
-
- EpiHealth: Epidemiology for Health
- Paediatrics (Lund)
- Childhood Cancer Research Unit (research group)
- Late effects after childhood cancer treatment (research group)
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Lund Melanoma Study Group (research group)
- Tumor microenvironment
- publishing date
- 2017-12-19
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Familial cancer predisposition, Genetic cancer susceptibility, Hereditary cancer syndrome, Pediatric cancer
- in
- BMC Cancer
- volume
- 17
- issue
- 1
- article number
- 868
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:29258538
- wos:000418718900003
- scopus:85038394967
- ISSN
- 1471-2407
- DOI
- 10.1186/s12885-017-3899-8
- project
- Cancer risk and predisposition in families with childhood cancer
- language
- English
- LU publication?
- yes
- id
- 1a96730a-8a28-45e6-94af-ea85191e12d5
- date added to LUP
- 2018-01-03 12:08:41
- date last changed
- 2025-01-08 01:31:58
@article{1a96730a-8a28-45e6-94af-ea85191e12d5, abstract = {{<p>Background: Recent studies indicate that one of four childhood cancers can be attributed to hereditary genetic abnormalities. Methods: The Lund Childhood Cancer Genetic study includes newly diagnosed childhood cancer patients as well as childhood cancer survivors visiting the Department of Pediatrics or the Late Effect Clinic at Skåne University Hospital, Lund, Sweden. Questionnaires regarding family history of cancer and blood samples were provided. Reported data were validated and extended by use of the Swedish Population- and Cancer Registries. Demographics in families with one case of childhood cancer (FAM1) were investigated and compared to families with multiple cases of childhood cancer (FAM > 1) as well as to childhood cancer in the general population. Results: Forty-one out of 528 families (7.8%) had more than one case of childhood cancer. In 23 families the affected children were relatives up to a 3rd degree (4.4%). In FAM > 1, 69.2% of the children with leukemia and 60% of those with tumors in the central nervous system (CNS) had a childhood relative with matching diagnosis, both significantly higher than expected. Significantly more female than male patients were observed in FAM > 1 compared to FAM1. This female predominance was most striking in childhood leukemia (77% female) and also, yet to a lesser extent, in CNS tumors (68% female). Conclusions: We conclude that the high proportion of children with leukemia or CNS tumors in FAM > 1 having a childhood relative with the same diagnosis suggests a hereditary background. Moreover, we report a female predominance in childhood leukemia and childhood CNS tumors in FAM > 1, which may indicate a hereditary gender-specific risk factor in these families.</p>}}, author = {{Stjernfelt, Karl Johan and von Stedingk, Kristoffer and Wiebe, Thomas and Hjorth, Lars and Olsson, Håkan and Øra, Ingrid}}, issn = {{1471-2407}}, keywords = {{Familial cancer predisposition; Genetic cancer susceptibility; Hereditary cancer syndrome; Pediatric cancer}}, language = {{eng}}, month = {{12}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Cancer}}, title = {{Predominance of girls with cancer in families with multiple childhood cancer cases}}, url = {{http://dx.doi.org/10.1186/s12885-017-3899-8}}, doi = {{10.1186/s12885-017-3899-8}}, volume = {{17}}, year = {{2017}}, }