The prevalence of renal amyloidosis of the AA-type in a series of 1,158 consecutive autopsies
(1987) In APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 95A(1-6). p.297-302- Abstract
To determine the prevalence of renal amyloidosis of the AA-type in a defined population, formalin-fixed specimens from the kidneys of all the cases autopsied in 1983 at The General Hospital of Malmö, Sweden, were investigated using immunohistochemical techniques. Amyloid deposits of protein AA were found in 10 of 1,158 investigated cases and the calculated prevalence was 0.86 per cent. The mean age at death of the individuals with the AA-type of amyloidosis was 79 years. Six of the cases with amyloidosis had rheumatoid arthritis. The avidin-biotin-peroxidase complex technique was found to be superior to the immunofluorescence method and a high sensitivity and specificity was achieved when sequence-specific antibodies against a... (More)
To determine the prevalence of renal amyloidosis of the AA-type in a defined population, formalin-fixed specimens from the kidneys of all the cases autopsied in 1983 at The General Hospital of Malmö, Sweden, were investigated using immunohistochemical techniques. Amyloid deposits of protein AA were found in 10 of 1,158 investigated cases and the calculated prevalence was 0.86 per cent. The mean age at death of the individuals with the AA-type of amyloidosis was 79 years. Six of the cases with amyloidosis had rheumatoid arthritis. The avidin-biotin-peroxidase complex technique was found to be superior to the immunofluorescence method and a high sensitivity and specificity was achieved when sequence-specific antibodies against a synthetized nonapeptide corresponding to a hydrophilic segment of the polypeptide chain of protein AA were used in the assay. Nine cases with other types of amyloid deposits in the kidneys were also detected. None of these cases showed any AA immunoreactivity but all of them demonstrated Congophilic deposits which were immunohistochemically stained by antibodies against the amyloid P-component. The prevalence of renal amyloidosis comprising all types of amyloid protein deposits was 1.64 per cent.
(Less)
- author
- Löfberg, Helge LU ; Grubb, Anders LU ; Thysell, Hans LU ; Nilsson, Elise LU ; Kjellander, Birgitta ; Möller, Christina ; Gruic, Vinka ; Ljungquist, Anne and Sternby, Nils H. LU
- organization
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, Aged, 80 and over, Amyloidosis/epidemiology, Autopsy, Female, Fluorescent Antibody Technique, Humans, Immunoenzyme Techniques, Kidney Diseases/epidemiology, Male, Middle Aged, Serum Amyloid A Protein/analysis
- in
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- volume
- 95A
- issue
- 1-6
- pages
- 297 - 302
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:3307298
- scopus:0023242997
- ISSN
- 0108-0164
- DOI
- 10.1111/j.1699-0463.1987.tb00044_95a.x
- language
- English
- LU publication?
- yes
- id
- 1ad073f3-6059-4060-ac62-eeb9324bc181
- date added to LUP
- 2021-10-26 15:24:08
- date last changed
- 2024-01-12 02:56:55
@article{1ad073f3-6059-4060-ac62-eeb9324bc181, abstract = {{<p>To determine the prevalence of renal amyloidosis of the AA-type in a defined population, formalin-fixed specimens from the kidneys of all the cases autopsied in 1983 at The General Hospital of Malmö, Sweden, were investigated using immunohistochemical techniques. Amyloid deposits of protein AA were found in 10 of 1,158 investigated cases and the calculated prevalence was 0.86 per cent. The mean age at death of the individuals with the AA-type of amyloidosis was 79 years. Six of the cases with amyloidosis had rheumatoid arthritis. The avidin-biotin-peroxidase complex technique was found to be superior to the immunofluorescence method and a high sensitivity and specificity was achieved when sequence-specific antibodies against a synthetized nonapeptide corresponding to a hydrophilic segment of the polypeptide chain of protein AA were used in the assay. Nine cases with other types of amyloid deposits in the kidneys were also detected. None of these cases showed any AA immunoreactivity but all of them demonstrated Congophilic deposits which were immunohistochemically stained by antibodies against the amyloid P-component. The prevalence of renal amyloidosis comprising all types of amyloid protein deposits was 1.64 per cent.</p>}}, author = {{Löfberg, Helge and Grubb, Anders and Thysell, Hans and Nilsson, Elise and Kjellander, Birgitta and Möller, Christina and Gruic, Vinka and Ljungquist, Anne and Sternby, Nils H.}}, issn = {{0108-0164}}, keywords = {{Aged; Aged, 80 and over; Amyloidosis/epidemiology; Autopsy; Female; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Kidney Diseases/epidemiology; Male; Middle Aged; Serum Amyloid A Protein/analysis}}, language = {{eng}}, number = {{1-6}}, pages = {{297--302}}, publisher = {{John Wiley & Sons Inc.}}, series = {{APMIS : acta pathologica, microbiologica, et immunologica Scandinavica}}, title = {{The prevalence of renal amyloidosis of the AA-type in a series of 1,158 consecutive autopsies}}, url = {{http://dx.doi.org/10.1111/j.1699-0463.1987.tb00044_95a.x}}, doi = {{10.1111/j.1699-0463.1987.tb00044_95a.x}}, volume = {{95A}}, year = {{1987}}, }