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The prevalence of renal amyloidosis of the AA-type in a series of 1,158 consecutive autopsies

Löfberg, Helge LU ; Grubb, Anders LU orcid ; Thysell, Hans LU ; Nilsson, Elise LU ; Kjellander, Birgitta ; Möller, Christina ; Gruic, Vinka ; Ljungquist, Anne and Sternby, Nils H. LU (1987) In APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 95A(1-6). p.297-302
Abstract

To determine the prevalence of renal amyloidosis of the AA-type in a defined population, formalin-fixed specimens from the kidneys of all the cases autopsied in 1983 at The General Hospital of Malmö, Sweden, were investigated using immunohistochemical techniques. Amyloid deposits of protein AA were found in 10 of 1,158 investigated cases and the calculated prevalence was 0.86 per cent. The mean age at death of the individuals with the AA-type of amyloidosis was 79 years. Six of the cases with amyloidosis had rheumatoid arthritis. The avidin-biotin-peroxidase complex technique was found to be superior to the immunofluorescence method and a high sensitivity and specificity was achieved when sequence-specific antibodies against a... (More)

To determine the prevalence of renal amyloidosis of the AA-type in a defined population, formalin-fixed specimens from the kidneys of all the cases autopsied in 1983 at The General Hospital of Malmö, Sweden, were investigated using immunohistochemical techniques. Amyloid deposits of protein AA were found in 10 of 1,158 investigated cases and the calculated prevalence was 0.86 per cent. The mean age at death of the individuals with the AA-type of amyloidosis was 79 years. Six of the cases with amyloidosis had rheumatoid arthritis. The avidin-biotin-peroxidase complex technique was found to be superior to the immunofluorescence method and a high sensitivity and specificity was achieved when sequence-specific antibodies against a synthetized nonapeptide corresponding to a hydrophilic segment of the polypeptide chain of protein AA were used in the assay. Nine cases with other types of amyloid deposits in the kidneys were also detected. None of these cases showed any AA immunoreactivity but all of them demonstrated Congophilic deposits which were immunohistochemically stained by antibodies against the amyloid P-component. The prevalence of renal amyloidosis comprising all types of amyloid protein deposits was 1.64 per cent.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, Aged, 80 and over, Amyloidosis/epidemiology, Autopsy, Female, Fluorescent Antibody Technique, Humans, Immunoenzyme Techniques, Kidney Diseases/epidemiology, Male, Middle Aged, Serum Amyloid A Protein/analysis
in
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
volume
95A
issue
1-6
pages
297 - 302
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:3307298
  • scopus:0023242997
ISSN
0108-0164
DOI
10.1111/j.1699-0463.1987.tb00044_95a.x
language
English
LU publication?
yes
id
1ad073f3-6059-4060-ac62-eeb9324bc181
date added to LUP
2021-10-26 15:24:08
date last changed
2024-01-12 02:56:55
@article{1ad073f3-6059-4060-ac62-eeb9324bc181,
  abstract     = {{<p>To determine the prevalence of renal amyloidosis of the AA-type in a defined population, formalin-fixed specimens from the kidneys of all the cases autopsied in 1983 at The General Hospital of Malmö, Sweden, were investigated using immunohistochemical techniques. Amyloid deposits of protein AA were found in 10 of 1,158 investigated cases and the calculated prevalence was 0.86 per cent. The mean age at death of the individuals with the AA-type of amyloidosis was 79 years. Six of the cases with amyloidosis had rheumatoid arthritis. The avidin-biotin-peroxidase complex technique was found to be superior to the immunofluorescence method and a high sensitivity and specificity was achieved when sequence-specific antibodies against a synthetized nonapeptide corresponding to a hydrophilic segment of the polypeptide chain of protein AA were used in the assay. Nine cases with other types of amyloid deposits in the kidneys were also detected. None of these cases showed any AA immunoreactivity but all of them demonstrated Congophilic deposits which were immunohistochemically stained by antibodies against the amyloid P-component. The prevalence of renal amyloidosis comprising all types of amyloid protein deposits was 1.64 per cent.</p>}},
  author       = {{Löfberg, Helge and Grubb, Anders and Thysell, Hans and Nilsson, Elise and Kjellander, Birgitta and Möller, Christina and Gruic, Vinka and Ljungquist, Anne and Sternby, Nils H.}},
  issn         = {{0108-0164}},
  keywords     = {{Aged; Aged, 80 and over; Amyloidosis/epidemiology; Autopsy; Female; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Kidney Diseases/epidemiology; Male; Middle Aged; Serum Amyloid A Protein/analysis}},
  language     = {{eng}},
  number       = {{1-6}},
  pages        = {{297--302}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{APMIS : acta pathologica, microbiologica, et immunologica Scandinavica}},
  title        = {{The prevalence of renal amyloidosis of the AA-type in a series of 1,158 consecutive autopsies}},
  url          = {{http://dx.doi.org/10.1111/j.1699-0463.1987.tb00044_95a.x}},
  doi          = {{10.1111/j.1699-0463.1987.tb00044_95a.x}},
  volume       = {{95A}},
  year         = {{1987}},
}