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OPTIMISATION AND PERFORMANCE QUANTIFICATION ACOUSTIC TRAPPING USING SYNTHETIC NANOPARTICLES

Havers, Megan LU orcid ; Novotný, Jakub LU orcid ; Gilbert, Jennifer LU orcid ; Laurell, Thomas LU ; Evander, Mikael LU and Lenshof, Andreas LU (2021) 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 p.903-904
Abstract

Acoustic trapping is becoming increasingly popular as a tool to isolate and enrich biological nanoparticles [1] (particularly extracellular vesicles [2]), yet an inherent problem with acoustic trapping of nanoparticles is calibration of the trapping efficiency. This abstract presents in-house synthesized nanoparticles with different sound scattering properties, either rigid high density gold nanoparticles (AuNPs) as model system for inorganic nanoparticles (NPs) or synthetic lipid bilayer nano vesicles to mimic the acoustic properties of biological vesicles. The rapid NP synthesis facilitates characterisation of the trapping performance of a single node acoustic trapping system, e.g. by designing application specific NPs size ladders.... (More)

Acoustic trapping is becoming increasingly popular as a tool to isolate and enrich biological nanoparticles [1] (particularly extracellular vesicles [2]), yet an inherent problem with acoustic trapping of nanoparticles is calibration of the trapping efficiency. This abstract presents in-house synthesized nanoparticles with different sound scattering properties, either rigid high density gold nanoparticles (AuNPs) as model system for inorganic nanoparticles (NPs) or synthetic lipid bilayer nano vesicles to mimic the acoustic properties of biological vesicles. The rapid NP synthesis facilitates characterisation of the trapping performance of a single node acoustic trapping system, e.g. by designing application specific NPs size ladders. This is shown by the trapping of AuNPs of two different sizes and synthetic lipid bilayer vesicles and demonstrating a 6-11% NP recovery. The work demonstrates the potential of freshly synthesized nanoparticles as a tool for optimisation of acoustic trapping protocols as well as a fast and simple NP trapping performance verification by visual inspection.

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Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Acoustic Trapping, Nanoparticles, Synthetic Vesicles
host publication
MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
pages
2 pages
publisher
Chemical and Biological Microsystems Society
conference name
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
conference location
Palm Springs, Virtual, United States
conference dates
2021-10-10 - 2021-10-14
external identifiers
  • scopus:85136929306
ISBN
9781733419031
language
English
LU publication?
yes
id
1ad27a87-3c0e-4683-9c96-a3cfa89e1540
date added to LUP
2022-11-08 10:02:00
date last changed
2023-10-23 06:29:03
@inproceedings{1ad27a87-3c0e-4683-9c96-a3cfa89e1540,
  abstract     = {{<p>Acoustic trapping is becoming increasingly popular as a tool to isolate and enrich biological nanoparticles [1] (particularly extracellular vesicles [2]), yet an inherent problem with acoustic trapping of nanoparticles is calibration of the trapping efficiency. This abstract presents in-house synthesized nanoparticles with different sound scattering properties, either rigid high density gold nanoparticles (AuNPs) as model system for inorganic nanoparticles (NPs) or synthetic lipid bilayer nano vesicles to mimic the acoustic properties of biological vesicles. The rapid NP synthesis facilitates characterisation of the trapping performance of a single node acoustic trapping system, e.g. by designing application specific NPs size ladders. This is shown by the trapping of AuNPs of two different sizes and synthetic lipid bilayer vesicles and demonstrating a 6-11% NP recovery. The work demonstrates the potential of freshly synthesized nanoparticles as a tool for optimisation of acoustic trapping protocols as well as a fast and simple NP trapping performance verification by visual inspection.</p>}},
  author       = {{Havers, Megan and Novotný, Jakub and Gilbert, Jennifer and Laurell, Thomas and Evander, Mikael and Lenshof, Andreas}},
  booktitle    = {{MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences}},
  isbn         = {{9781733419031}},
  keywords     = {{Acoustic Trapping; Nanoparticles; Synthetic Vesicles}},
  language     = {{eng}},
  pages        = {{903--904}},
  publisher    = {{Chemical and Biological Microsystems Society}},
  title        = {{OPTIMISATION AND PERFORMANCE QUANTIFICATION ACOUSTIC TRAPPING USING SYNTHETIC NANOPARTICLES}},
  year         = {{2021}},
}