Shunt-type plexiform lesions identified in the Sugen5416/Hypoxia rat model of pulmonary arterial hypertension using SPµCT
(2022) In The European respiratory journal 59(6).- Abstract
- We recently described four distinct types of plexiform lesions in human idiopathic and familial pulmonary arterial hypertension (PAH) [1], visualising the three-dimensional lesion structure using synchrotron-based phase-contrast micro-CT (SPµCT). Two types, 1 and 2, are shunt-type lesions that connect pulmonary arteries to the bronchial circulation: type 1 to the vasa vasorum, and type 2 to peribronchial vessels. Type 3 lesions are found peripherally in the lung as spherical structures abruptly terminating the distal pulmonary artery/arteriole, and type 4 are characterised by recanalization of an occluded artery/arteriole. Our observation of type 1 and type 2 lesions in PAH supports previous work which demonstrated intrapulmonary... (More)
- We recently described four distinct types of plexiform lesions in human idiopathic and familial pulmonary arterial hypertension (PAH) [1], visualising the three-dimensional lesion structure using synchrotron-based phase-contrast micro-CT (SPµCT). Two types, 1 and 2, are shunt-type lesions that connect pulmonary arteries to the bronchial circulation: type 1 to the vasa vasorum, and type 2 to peribronchial vessels. Type 3 lesions are found peripherally in the lung as spherical structures abruptly terminating the distal pulmonary artery/arteriole, and type 4 are characterised by recanalization of an occluded artery/arteriole. Our observation of type 1 and type 2 lesions in PAH supports previous work which demonstrated intrapulmonary bronchopulmonary anastomoses (IBAs) connected to plexiform lesions in human PAH, suggesting that shunting of blood can occur within lesions in the setting of supra-systemic pulmonary arterial pressure [2]. Further hemodynamic studies of distinct subtypes of plexiform lesions have been hampered by the lack of available animal models with plexiform lesions representative of the full range of lesion types found in human disease. Plexiform lesions have previously been described in the Sugen5416/Hypoxia rat model of pulmonary hypertension when time until sacrifice following hypoxia is extended to 13–14 weeks. Initially plexiform lesions were identified within the lumen as well as outside the vessel as aneurysm-like lesions [3], and recently the latter type was shown to form in supernumerary arteries [4]. However, neither study observed plexiform lesions communicating with the bronchial circulation, possibly because of methodological limitations of the histological analysis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1b18f454-0fcf-4f41-9fd2-99c2abad1ff8
- author
- van der Have, Oscar
LU
; Westöö, Christian LU ; Ahrné, Filip ; Tian, Xuefei ; Ichimura, Kenzo ; Dreier, Till LU
; Norvik, Christian LU ; Kumar, Maya E ; Spiekerkoetter, Edda and Tran-Lundmark, Karin LU
- organization
- publishing date
- 2022-03-24
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The European respiratory journal
- volume
- 59
- issue
- 6
- article number
- 2102802
- publisher
- European Respiratory Society
- external identifiers
-
- scopus:85131770800
- pmid:35332070
- ISSN
- 1399-3003
- DOI
- 10.1183/13993003.02802-2021
- language
- English
- LU publication?
- yes
- id
- 1b18f454-0fcf-4f41-9fd2-99c2abad1ff8
- date added to LUP
- 2022-04-16 16:44:46
- date last changed
- 2024-06-13 19:30:30
@article{1b18f454-0fcf-4f41-9fd2-99c2abad1ff8, abstract = {{We recently described four distinct types of plexiform lesions in human idiopathic and familial pulmonary arterial hypertension (PAH) [1], visualising the three-dimensional lesion structure using synchrotron-based phase-contrast micro-CT (SPµCT). Two types, 1 and 2, are shunt-type lesions that connect pulmonary arteries to the bronchial circulation: type 1 to the vasa vasorum, and type 2 to peribronchial vessels. Type 3 lesions are found peripherally in the lung as spherical structures abruptly terminating the distal pulmonary artery/arteriole, and type 4 are characterised by recanalization of an occluded artery/arteriole. Our observation of type 1 and type 2 lesions in PAH supports previous work which demonstrated intrapulmonary bronchopulmonary anastomoses (IBAs) connected to plexiform lesions in human PAH, suggesting that shunting of blood can occur within lesions in the setting of supra-systemic pulmonary arterial pressure [2]. Further hemodynamic studies of distinct subtypes of plexiform lesions have been hampered by the lack of available animal models with plexiform lesions representative of the full range of lesion types found in human disease. Plexiform lesions have previously been described in the Sugen5416/Hypoxia rat model of pulmonary hypertension when time until sacrifice following hypoxia is extended to 13–14 weeks. Initially plexiform lesions were identified within the lumen as well as outside the vessel as aneurysm-like lesions [3], and recently the latter type was shown to form in supernumerary arteries [4]. However, neither study observed plexiform lesions communicating with the bronchial circulation, possibly because of methodological limitations of the histological analysis.}}, author = {{van der Have, Oscar and Westöö, Christian and Ahrné, Filip and Tian, Xuefei and Ichimura, Kenzo and Dreier, Till and Norvik, Christian and Kumar, Maya E and Spiekerkoetter, Edda and Tran-Lundmark, Karin}}, issn = {{1399-3003}}, language = {{eng}}, month = {{03}}, number = {{6}}, publisher = {{European Respiratory Society}}, series = {{The European respiratory journal}}, title = {{Shunt-type plexiform lesions identified in the Sugen5416/Hypoxia rat model of pulmonary arterial hypertension using SPµCT}}, url = {{http://dx.doi.org/10.1183/13993003.02802-2021}}, doi = {{10.1183/13993003.02802-2021}}, volume = {{59}}, year = {{2022}}, }