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Shunt-type plexiform lesions identified in the Sugen5416/Hypoxia rat model of pulmonary arterial hypertension using SPµCT

van der Have, Oscar LU orcid ; Westöö, Christian LU ; Ahrné, Filip ; Tian, Xuefei ; Ichimura, Kenzo ; Dreier, Till LU orcid ; Norvik, Christian LU ; Kumar, Maya E ; Spiekerkoetter, Edda and Tran-Lundmark, Karin LU (2022) In The European respiratory journal 59(6).
Abstract
We recently described four distinct types of plexiform lesions in human idiopathic and familial pulmonary arterial hypertension (PAH) [1], visualising the three-dimensional lesion structure using synchrotron-based phase-contrast micro-CT (SPµCT). Two types, 1 and 2, are shunt-type lesions that connect pulmonary arteries to the bronchial circulation: type 1 to the vasa vasorum, and type 2 to peribronchial vessels. Type 3 lesions are found peripherally in the lung as spherical structures abruptly terminating the distal pulmonary artery/arteriole, and type 4 are characterised by recanalization of an occluded artery/arteriole. Our observation of type 1 and type 2 lesions in PAH supports previous work which demonstrated intrapulmonary... (More)
We recently described four distinct types of plexiform lesions in human idiopathic and familial pulmonary arterial hypertension (PAH) [1], visualising the three-dimensional lesion structure using synchrotron-based phase-contrast micro-CT (SPµCT). Two types, 1 and 2, are shunt-type lesions that connect pulmonary arteries to the bronchial circulation: type 1 to the vasa vasorum, and type 2 to peribronchial vessels. Type 3 lesions are found peripherally in the lung as spherical structures abruptly terminating the distal pulmonary artery/arteriole, and type 4 are characterised by recanalization of an occluded artery/arteriole. Our observation of type 1 and type 2 lesions in PAH supports previous work which demonstrated intrapulmonary bronchopulmonary anastomoses (IBAs) connected to plexiform lesions in human PAH, suggesting that shunting of blood can occur within lesions in the setting of supra-systemic pulmonary arterial pressure [2]. Further hemodynamic studies of distinct subtypes of plexiform lesions have been hampered by the lack of available animal models with plexiform lesions representative of the full range of lesion types found in human disease. Plexiform lesions have previously been described in the Sugen5416/Hypoxia rat model of pulmonary hypertension when time until sacrifice following hypoxia is extended to 13–14 weeks. Initially plexiform lesions were identified within the lumen as well as outside the vessel as aneurysm-like lesions [3], and recently the latter type was shown to form in supernumerary arteries [4]. However, neither study observed plexiform lesions communicating with the bronchial circulation, possibly because of methodological limitations of the histological analysis. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The European respiratory journal
volume
59
issue
6
article number
2102802
publisher
European Respiratory Society
external identifiers
  • scopus:85131770800
  • pmid:35332070
ISSN
1399-3003
DOI
10.1183/13993003.02802-2021
language
English
LU publication?
yes
id
1b18f454-0fcf-4f41-9fd2-99c2abad1ff8
date added to LUP
2022-04-16 16:44:46
date last changed
2024-06-13 19:30:30
@article{1b18f454-0fcf-4f41-9fd2-99c2abad1ff8,
  abstract     = {{We recently described four distinct types of plexiform lesions in human idiopathic and familial pulmonary arterial hypertension (PAH) [1], visualising the three-dimensional lesion structure using synchrotron-based phase-contrast micro-CT (SPµCT). Two types, 1 and 2, are shunt-type lesions that connect pulmonary arteries to the bronchial circulation: type 1 to the vasa vasorum, and type 2 to peribronchial vessels. Type 3 lesions are found peripherally in the lung as spherical structures abruptly terminating the distal pulmonary artery/arteriole, and type 4 are characterised by recanalization of an occluded artery/arteriole. Our observation of type 1 and type 2 lesions in PAH supports previous work which demonstrated intrapulmonary bronchopulmonary anastomoses (IBAs) connected to plexiform lesions in human PAH, suggesting that shunting of blood can occur within lesions in the setting of supra-systemic pulmonary arterial pressure [2]. Further hemodynamic studies of distinct subtypes of plexiform lesions have been hampered by the lack of available animal models with plexiform lesions representative of the full range of lesion types found in human disease. Plexiform lesions have previously been described in the Sugen5416/Hypoxia rat model of pulmonary hypertension when time until sacrifice following hypoxia is extended to 13–14 weeks. Initially plexiform lesions were identified within the lumen as well as outside the vessel as aneurysm-like lesions [3], and recently the latter type was shown to form in supernumerary arteries [4]. However, neither study observed plexiform lesions communicating with the bronchial circulation, possibly because of methodological limitations of the histological analysis.}},
  author       = {{van der Have, Oscar and Westöö, Christian and Ahrné, Filip and Tian, Xuefei and Ichimura, Kenzo and Dreier, Till and Norvik, Christian and Kumar, Maya E and Spiekerkoetter, Edda and Tran-Lundmark, Karin}},
  issn         = {{1399-3003}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{6}},
  publisher    = {{European Respiratory Society}},
  series       = {{The European respiratory journal}},
  title        = {{Shunt-type plexiform lesions identified in the Sugen5416/Hypoxia rat model of pulmonary arterial hypertension using SPµCT}},
  url          = {{http://dx.doi.org/10.1183/13993003.02802-2021}},
  doi          = {{10.1183/13993003.02802-2021}},
  volume       = {{59}},
  year         = {{2022}},
}