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Oral contraceptives and breast cancer : A review

Olsson, H. LU (1989) In Acta Oncologica 28(6). p.849-863
Abstract

Case-control and cohort studies published between 1977 and 1988 were reviewed with the purpose to evaluate the relationship between use of oral contraceptives (OC-use) and breast cancer risk, tumour biology and tumour prognosis with special emphasis on early OC-use. the risk of breast cancer was assessed in 30 case-referent studies and 5 cohort studies, and the prognosis of breast cancer had been studied in 9 reports. Definition of OC-use. prevalence of OC-use, latency time between start of OC-use and tumour diagnosis, case identification and choice of referents. study size, study quality were assessed. the outcome of the studies is presented. From the results of the analyses the author concludes that there is no overall risk for breast... (More)

Case-control and cohort studies published between 1977 and 1988 were reviewed with the purpose to evaluate the relationship between use of oral contraceptives (OC-use) and breast cancer risk, tumour biology and tumour prognosis with special emphasis on early OC-use. the risk of breast cancer was assessed in 30 case-referent studies and 5 cohort studies, and the prognosis of breast cancer had been studied in 9 reports. Definition of OC-use. prevalence of OC-use, latency time between start of OC-use and tumour diagnosis, case identification and choice of referents. study size, study quality were assessed. the outcome of the studies is presented. From the results of the analyses the author concludes that there is no overall risk for breast cancer among OC-users. However, with the emphasis on early OC-use, consistent results seem to emerge showing an increased risk of premenopausal breast cancer, when the possible bias of different latency times is taken into account. Also results on breast cancer incidence in early exposed age groups, tumour biology and prognosis in early OC-users with breast cancer support a genuine risk relationship. the effects of different OC-brands and dose, and the risk of peri- and postmenopausal breast cancer after early OC-use can at present not be assessed.

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Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Breast cancer, Epidemiologic studies, Oral contraceptives, Review, Risk estimates
in
Acta Oncologica
volume
28
issue
6
pages
849 - 863
publisher
Taylor & Francis
external identifiers
  • scopus:0024841124
ISSN
0284-186X
DOI
10.3109/02841868909092320
language
English
LU publication?
no
id
1b5bc5e3-ce63-4571-92a0-c99ad44f2896
date added to LUP
2018-12-18 13:37:52
date last changed
2019-01-06 14:20:32
@article{1b5bc5e3-ce63-4571-92a0-c99ad44f2896,
  abstract     = {<p>Case-control and cohort studies published between 1977 and 1988 were reviewed with the purpose to evaluate the relationship between use of oral contraceptives (OC-use) and breast cancer risk, tumour biology and tumour prognosis with special emphasis on early OC-use. the risk of breast cancer was assessed in 30 case-referent studies and 5 cohort studies, and the prognosis of breast cancer had been studied in 9 reports. Definition of OC-use. prevalence of OC-use, latency time between start of OC-use and tumour diagnosis, case identification and choice of referents. study size, study quality were assessed. the outcome of the studies is presented. From the results of the analyses the author concludes that there is no overall risk for breast cancer among OC-users. However, with the emphasis on early OC-use, consistent results seem to emerge showing an increased risk of premenopausal breast cancer, when the possible bias of different latency times is taken into account. Also results on breast cancer incidence in early exposed age groups, tumour biology and prognosis in early OC-users with breast cancer support a genuine risk relationship. the effects of different OC-brands and dose, and the risk of peri- and postmenopausal breast cancer after early OC-use can at present not be assessed.</p>},
  author       = {Olsson, H.},
  issn         = {0284-186X},
  keyword      = {Breast cancer,Epidemiologic studies,Oral contraceptives,Review,Risk estimates},
  language     = {eng},
  month        = {01},
  number       = {6},
  pages        = {849--863},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Oral contraceptives and breast cancer : A review},
  url          = {http://dx.doi.org/10.3109/02841868909092320},
  volume       = {28},
  year         = {1989},
}