Advanced

Incremental value of circulating MiR-122-5P to predict outcome after out of hospital cardiac arrest

Devaux, Yvan; Salgado-Somoza, Antonio; Dankiewicz, Josef LU ; Boileau, Adeline; Stammet, Pascal; Schritz, Anna; Zhang, Lu Lu; Vausort, Mélanie; Gilje, Patrik LU and Erlinge, David LU , et al. (2017) In Theranostics 7(10). p.2555-2564
Abstract

Rationale. The value of microRNAs (miRNAs) as biomarkers has been addressed in various clinical contexts. Initial studies suggested that miRNAs, such as the brain-enriched miR-124-3p, might improve outcome prediction after out-of-hospital cardiac arrest. The aim of this study is to determine the prognostic value of miR-122-5p in a large cohort of comatose survivors of out-of-hospital cardiac arrest. Methods. We analyzed 590 patients from the Targeted Temperature Management trial (TTM-trial). Circulating levels of miR-122-5p were measured in serum samples obtained 48 hours after return of spontaneous circulation. The primary end-point was poor neurological outcome at 6 months evaluated by the cerebral performance category score. The... (More)

Rationale. The value of microRNAs (miRNAs) as biomarkers has been addressed in various clinical contexts. Initial studies suggested that miRNAs, such as the brain-enriched miR-124-3p, might improve outcome prediction after out-of-hospital cardiac arrest. The aim of this study is to determine the prognostic value of miR-122-5p in a large cohort of comatose survivors of out-of-hospital cardiac arrest. Methods. We analyzed 590 patients from the Targeted Temperature Management trial (TTM-trial). Circulating levels of miR-122-5p were measured in serum samples obtained 48 hours after return of spontaneous circulation. The primary end-point was poor neurological outcome at 6 months evaluated by the cerebral performance category score. The secondary end-point was survival at the end of the trial. Results. Forty-eight percent of patients had a poor neurological outcome at 6 months and 43% were dead at the end of the trial. Levels of miR-122-5p were lower in patients with poor neurological outcome compared to patients with good neurological outcome (p < 0.001), independently of targeted temperature management regimen. Levels of miR-122-5p were significant univariate predictors of neurological outcome (odds ratios (OR), 95% confidence intervals (CI): 0.71 [0.57-0.88]). In multivariable analyses, miR-122-5p was an independent predictor of neurological outcome and improved the predictive value of a clinical model including miR-124-3p (integrated discrimination improvement of 0.03 [0.02-0.04]). In Cox proportional hazards models, miR-122-5p was a significant predictor of survival at the end of the trial. Conclusion. Circulating levels of miR-122-5p improve the prediction of outcome after out-of-hospital cardiac arrest.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarker, Cardiac arrest, microRNAs, Neurological function, Prognostic
in
Theranostics
volume
7
issue
10
pages
10 pages
publisher
Ivyspring International Publisher
external identifiers
  • scopus:85021202958
  • wos:000404028500001
ISSN
1838-7640
DOI
10.7150/thno.19851
language
English
LU publication?
yes
id
1baa46a0-d8b3-4482-ac93-7ab9081bbc08
date added to LUP
2017-08-18 14:27:40
date last changed
2018-09-09 04:53:36
@article{1baa46a0-d8b3-4482-ac93-7ab9081bbc08,
  abstract     = {<p>Rationale. The value of microRNAs (miRNAs) as biomarkers has been addressed in various clinical contexts. Initial studies suggested that miRNAs, such as the brain-enriched miR-124-3p, might improve outcome prediction after out-of-hospital cardiac arrest. The aim of this study is to determine the prognostic value of miR-122-5p in a large cohort of comatose survivors of out-of-hospital cardiac arrest. Methods. We analyzed 590 patients from the Targeted Temperature Management trial (TTM-trial). Circulating levels of miR-122-5p were measured in serum samples obtained 48 hours after return of spontaneous circulation. The primary end-point was poor neurological outcome at 6 months evaluated by the cerebral performance category score. The secondary end-point was survival at the end of the trial. Results. Forty-eight percent of patients had a poor neurological outcome at 6 months and 43% were dead at the end of the trial. Levels of miR-122-5p were lower in patients with poor neurological outcome compared to patients with good neurological outcome (p &lt; 0.001), independently of targeted temperature management regimen. Levels of miR-122-5p were significant univariate predictors of neurological outcome (odds ratios (OR), 95% confidence intervals (CI): 0.71 [0.57-0.88]). In multivariable analyses, miR-122-5p was an independent predictor of neurological outcome and improved the predictive value of a clinical model including miR-124-3p (integrated discrimination improvement of 0.03 [0.02-0.04]). In Cox proportional hazards models, miR-122-5p was a significant predictor of survival at the end of the trial. Conclusion. Circulating levels of miR-122-5p improve the prediction of outcome after out-of-hospital cardiac arrest.</p>},
  author       = {Devaux, Yvan and Salgado-Somoza, Antonio and Dankiewicz, Josef and Boileau, Adeline and Stammet, Pascal and Schritz, Anna and Zhang, Lu Lu and Vausort, Mélanie and Gilje, Patrik and Erlinge, David and Hassager, Christian and Wise, Matthew P and Kuiper, Michael and Friberg, Hans and Nielsen, Niklas and ,  and , },
  issn         = {1838-7640},
  keyword      = {Biomarker,Cardiac arrest,microRNAs,Neurological function,Prognostic},
  language     = {eng},
  number       = {10},
  pages        = {2555--2564},
  publisher    = {Ivyspring International Publisher},
  series       = {Theranostics},
  title        = {Incremental value of circulating MiR-122-5P to predict outcome after out of hospital cardiac arrest},
  url          = {http://dx.doi.org/10.7150/thno.19851},
  volume       = {7},
  year         = {2017},
}