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Non-coding RNAs to aid in neurological prognosis after cardiac arrest

Salgado-Somoza, Antonio; Stefanizzi, Francesca Maria; Stammet, Pascal; Erlinge, David LU ; Friberg, Hans LU ; Nielsen, Niklas LU and Devaux, Yvan (2018) In Non-coding RNA 4(4).
Abstract

Cardiovascular disease in general, and sudden cardiac death in particular, have an enormous socio-economic burden worldwide. Despite significant efforts to improve cardiopulmonary resuscitation, survival rates remain low. Moreover, patients who survive to hospital discharge have a high risk of developing severe physical or neurological symptoms. Being able to predict outcomes after resuscitation from cardiac arrest would make it possible to tailor healthcare approaches, thereby maximising efforts for those who would mostly benefit from aggressive therapy. However, the identification of patients at risk of poor recovery after cardiac arrest is still a challenging task which could be facilitated by novel biomarkers. Recent investigations... (More)

Cardiovascular disease in general, and sudden cardiac death in particular, have an enormous socio-economic burden worldwide. Despite significant efforts to improve cardiopulmonary resuscitation, survival rates remain low. Moreover, patients who survive to hospital discharge have a high risk of developing severe physical or neurological symptoms. Being able to predict outcomes after resuscitation from cardiac arrest would make it possible to tailor healthcare approaches, thereby maximising efforts for those who would mostly benefit from aggressive therapy. However, the identification of patients at risk of poor recovery after cardiac arrest is still a challenging task which could be facilitated by novel biomarkers. Recent investigations have recognised the potential of non-coding RNAs to aid in outcome prediction after cardiac arrest. In this review, we summarize recent discoveries and propose a handful of novel perspectives for the use of non-coding RNAs to predict outcome after cardiac arrest, discussing their use for precision medicine.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, Cardiac arrest, Non-coding RNAs
in
Non-coding RNA
volume
4
issue
4
publisher
MDPI AG
external identifiers
  • scopus:85059465632
DOI
10.3390/ncrna4040042
language
English
LU publication?
yes
id
1c79a28c-a575-4ea5-b8ce-08323b7ddeb7
date added to LUP
2019-01-23 12:38:08
date last changed
2019-02-20 11:44:01
@article{1c79a28c-a575-4ea5-b8ce-08323b7ddeb7,
  abstract     = {<p>Cardiovascular disease in general, and sudden cardiac death in particular, have an enormous socio-economic burden worldwide. Despite significant efforts to improve cardiopulmonary resuscitation, survival rates remain low. Moreover, patients who survive to hospital discharge have a high risk of developing severe physical or neurological symptoms. Being able to predict outcomes after resuscitation from cardiac arrest would make it possible to tailor healthcare approaches, thereby maximising efforts for those who would mostly benefit from aggressive therapy. However, the identification of patients at risk of poor recovery after cardiac arrest is still a challenging task which could be facilitated by novel biomarkers. Recent investigations have recognised the potential of non-coding RNAs to aid in outcome prediction after cardiac arrest. In this review, we summarize recent discoveries and propose a handful of novel perspectives for the use of non-coding RNAs to predict outcome after cardiac arrest, discussing their use for precision medicine.</p>},
  articleno    = {42},
  author       = {Salgado-Somoza, Antonio and Stefanizzi, Francesca Maria and Stammet, Pascal and Erlinge, David and Friberg, Hans and Nielsen, Niklas and Devaux, Yvan},
  keyword      = {Biomarkers,Cardiac arrest,Non-coding RNAs},
  language     = {eng},
  month        = {12},
  number       = {4},
  publisher    = {MDPI AG},
  series       = {Non-coding RNA},
  title        = {Non-coding RNAs to aid in neurological prognosis after cardiac arrest},
  url          = {http://dx.doi.org/10.3390/ncrna4040042},
  volume       = {4},
  year         = {2018},
}