Multiple sclerosis among first- and second-generation immigrant groups in Sweden
(2020) In Acta Neurologica Scandinavica 142(4). p.339-349- Abstract
Objectives: Risk of multiple sclerosis (MS) is low among first-generation immigrants in Sweden. We aimed to study incident MS in first- and second-generation immigrant groups. Materials & Methods: We included adults aged 18 years and older in Sweden in first-generation (n = 6 042 891) and second-generation (n = 4 860 469) sub-studies. MS was defined via two diagnoses in the Swedish National Patient Register. MS risk was estimated by Cox regression, with hazard ratios (HRs) and 95% confidence intervals (CI), in different immigrant groups, using Swedish-born as referents in first-generation sub-study, and individuals with Swedish-born parents in the second-generation. Full models were adjusted for age, geographic residence in Sweden,... (More)
Objectives: Risk of multiple sclerosis (MS) is low among first-generation immigrants in Sweden. We aimed to study incident MS in first- and second-generation immigrant groups. Materials & Methods: We included adults aged 18 years and older in Sweden in first-generation (n = 6 042 891) and second-generation (n = 4 860 469) sub-studies. MS was defined via two diagnoses in the Swedish National Patient Register. MS risk was estimated by Cox regression, with hazard ratios (HRs) and 95% confidence intervals (CI), in different immigrant groups, using Swedish-born as referents in first-generation sub-study, and individuals with Swedish-born parents in the second-generation. Full models were adjusted for age, geographic residence in Sweden, educational level, marital status, neighborhood socioeconomic status, and co-morbidity. Results: MS was diagnosed among 10 746 individuals in the first-generation sub-study, (men 3055 and women 7691), and 11 737 in the second-generation sub-study (men 3549 and women 8188) in the period 1998-2015. The annual incidence rate was higher in Swedish-born compared to foreign-born, 11.5 vs 6.3 per 100 000 person-years (age-standardized to the European standard population). Fully adjusted HRs were lower in first-generation immigrant men (HR 0.72, 0.64-0.82) and women (HR 0.67, 0.62-0.73), and in second-generation immigrant men (HR 0.88, 0.79-0.97) and women (HR 0.79; 0.73-0.84). Among first-generation immigrants, lower HRs were found in most groups. Significance: The MS risk was lower in first- and second-generation immigrants compared to Swedish-born or individuals with Swedish-born parents.
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- author
- Wändell, Per LU ; Fredrikson, Sten ; Carlsson, Axel C. ; Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2020-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- gender, immigrants, multiple sclerosis, neighborhood, socioeconomic status
- in
- Acta Neurologica Scandinavica
- volume
- 142
- issue
- 4
- pages
- 11 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85088313739
- pmid:32648932
- ISSN
- 0001-6314
- DOI
- 10.1111/ane.13314
- language
- English
- LU publication?
- yes
- id
- 1c91431d-11ad-485c-86db-f6c69ccb1e80
- date added to LUP
- 2021-01-26 13:24:48
- date last changed
- 2024-10-03 18:27:05
@article{1c91431d-11ad-485c-86db-f6c69ccb1e80, abstract = {{<p>Objectives: Risk of multiple sclerosis (MS) is low among first-generation immigrants in Sweden. We aimed to study incident MS in first- and second-generation immigrant groups. Materials & Methods: We included adults aged 18 years and older in Sweden in first-generation (n = 6 042 891) and second-generation (n = 4 860 469) sub-studies. MS was defined via two diagnoses in the Swedish National Patient Register. MS risk was estimated by Cox regression, with hazard ratios (HRs) and 95% confidence intervals (CI), in different immigrant groups, using Swedish-born as referents in first-generation sub-study, and individuals with Swedish-born parents in the second-generation. Full models were adjusted for age, geographic residence in Sweden, educational level, marital status, neighborhood socioeconomic status, and co-morbidity. Results: MS was diagnosed among 10 746 individuals in the first-generation sub-study, (men 3055 and women 7691), and 11 737 in the second-generation sub-study (men 3549 and women 8188) in the period 1998-2015. The annual incidence rate was higher in Swedish-born compared to foreign-born, 11.5 vs 6.3 per 100 000 person-years (age-standardized to the European standard population). Fully adjusted HRs were lower in first-generation immigrant men (HR 0.72, 0.64-0.82) and women (HR 0.67, 0.62-0.73), and in second-generation immigrant men (HR 0.88, 0.79-0.97) and women (HR 0.79; 0.73-0.84). Among first-generation immigrants, lower HRs were found in most groups. Significance: The MS risk was lower in first- and second-generation immigrants compared to Swedish-born or individuals with Swedish-born parents.</p>}}, author = {{Wändell, Per and Fredrikson, Sten and Carlsson, Axel C. and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina}}, issn = {{0001-6314}}, keywords = {{gender; immigrants; multiple sclerosis; neighborhood; socioeconomic status}}, language = {{eng}}, month = {{10}}, number = {{4}}, pages = {{339--349}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Neurologica Scandinavica}}, title = {{Multiple sclerosis among first- and second-generation immigrant groups in Sweden}}, url = {{http://dx.doi.org/10.1111/ane.13314}}, doi = {{10.1111/ane.13314}}, volume = {{142}}, year = {{2020}}, }