Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies
Javanshiri, Keivan LU
; Drakenberg, Tove
; Haglund, Mattias
LU
and Englund, Elisabet
LU
(2022)
In Journal of Parkinson's Disease
12(4).
p.1125-1131
- Abstract
- Background: Alpha-synucleinopathies (AS) are characterized by pathologic aggregations of alpha-synuclein (α-syn) in the central nervous system, and comprise dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. Previous studies on AS have reported findings of α-syn pathology in the peripheral nervous system of multiple organs, including the heart.
Objective: The aim of this study was to further investigate and confirm the presence of cardiac α-syn in AS compared to other major neurocognitive disorders in a neuropathologically confirmed cohort.
Methods: All deceased patients with performed autopsy and with neuropathologically confirmed AS at the Clinical Department of Pathology in Lund 2010-May 2021... (More) - Background: Alpha-synucleinopathies (AS) are characterized by pathologic aggregations of alpha-synuclein (α-syn) in the central nervous system, and comprise dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. Previous studies on AS have reported findings of α-syn pathology in the peripheral nervous system of multiple organs, including the heart.
Objective: The aim of this study was to further investigate and confirm the presence of cardiac α-syn in AS compared to other major neurocognitive disorders in a neuropathologically confirmed cohort.
Methods: All deceased patients with performed autopsy and with neuropathologically confirmed AS at the Clinical Department of Pathology in Lund 2010-May 2021 were evaluated for inclusion. Cases with insufficiently sampled cardiac tissue or only limited neuropathological investigation were excluded. An age-matched group of individuals with other neurodegenerative diseases, having no α-syn in the CNS, served as controls. In total, 68 AS and 32 control cases were included in the study. Immunohistochemistry for detection of cardiac α-syn aggregates was performed.
Results: The AS group had a significantly higher prevalence of cardiac α-syn pathology (p≤0.001) than the control group, 82% and 0%, respectively.
Conclusion: This study confirms the association between AS and the presence of cardiac α-syn in a neuropathologically confirmed cohort. This motivates further research on potential pathophysiological effects on cardiac function in AS patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1c9bc7e8-53ec-4fd6-b76f-aba5e5891007
- author
- Javanshiri, Keivan
LU
; Drakenberg, Tove
; Haglund, Mattias
LU
and Englund, Elisabet
LU
- organization
- publishing date
- 2022-05-24
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Parkinson's Disease
- volume
- 12
- issue
- 4
- pages
- 1125 - 1131
- publisher
- IOS Press
- external identifiers
-
- pmid:35275559
- scopus:85131198125
- ISSN
- 1877-718X
- DOI
- 10.3233/JPD-223161
- project
- Cardiac and vascular pathology in Lewy body disease and Alzheimer's disease: exploring neurocognitive disorder beyond the brain
- language
- English
- LU publication?
- yes
- id
- 1c9bc7e8-53ec-4fd6-b76f-aba5e5891007
- date added to LUP
- 2022-06-19 12:43:06
- date last changed
- 2023-05-15 10:56:18
@article{1c9bc7e8-53ec-4fd6-b76f-aba5e5891007,
abstract = {{Background: Alpha-synucleinopathies (AS) are characterized by pathologic aggregations of alpha-synuclein (α-syn) in the central nervous system, and comprise dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. Previous studies on AS have reported findings of α-syn pathology in the peripheral nervous system of multiple organs, including the heart.<br/><br/>Objective: The aim of this study was to further investigate and confirm the presence of cardiac α-syn in AS compared to other major neurocognitive disorders in a neuropathologically confirmed cohort.<br/><br/>Methods: All deceased patients with performed autopsy and with neuropathologically confirmed AS at the Clinical Department of Pathology in Lund 2010-May 2021 were evaluated for inclusion. Cases with insufficiently sampled cardiac tissue or only limited neuropathological investigation were excluded. An age-matched group of individuals with other neurodegenerative diseases, having no α-syn in the CNS, served as controls. In total, 68 AS and 32 control cases were included in the study. Immunohistochemistry for detection of cardiac α-syn aggregates was performed.<br/><br/>Results: The AS group had a significantly higher prevalence of cardiac α-syn pathology (p≤0.001) than the control group, 82% and 0%, respectively.<br/><br/>Conclusion: This study confirms the association between AS and the presence of cardiac α-syn in a neuropathologically confirmed cohort. This motivates further research on potential pathophysiological effects on cardiac function in AS patients.}},
author = {{Javanshiri, Keivan and Drakenberg, Tove and Haglund, Mattias and Englund, Elisabet}},
issn = {{1877-718X}},
language = {{eng}},
month = {{05}},
number = {{4}},
pages = {{1125--1131}},
publisher = {{IOS Press}},
series = {{Journal of Parkinson's Disease}},
title = {{Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies}},
url = {{http://dx.doi.org/10.3233/JPD-223161}},
doi = {{10.3233/JPD-223161}},
volume = {{12}},
year = {{2022}},
}