Stem cell therapy for Parkinson's disease: where do we stand?
(2004) In Cell and Tissue Research 318(1). p.261-273- Abstract
- A major neuropathological feature of Parkinson's disease (PD) is the loss of nigrostriatal dopaminergic neuron. Patients exhibit motor symptoms, including bradykinesia, rigidity, and tremor. Neural grafting has been reported to restore striatial dopaminergic neurotransmission and induce symptomatic relief. The major limitation of cell replacement therapy for PD is the shortage of suitable donor tissue. The present review describes the possible sources of cells, including embryonic stem cells and somatic adult stem cells, both of which potentially could be used in cell therapy for PD, and discusses the advantages and disadvantages of each cell type.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/126710
- author
- Roybon, Laurent LU ; Christophersen, Nicolaj LU ; Brundin, Patrik LU and Li, Jia-Yi LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Parkinson's disease, Neural grafting, Embryonic stem cells, Somatic adult stem cells
- in
- Cell and Tissue Research
- volume
- 318
- issue
- 1
- pages
- 261 - 273
- publisher
- Springer
- external identifiers
-
- wos:000224618200027
- pmid:15309619
- scopus:5444236167
- ISSN
- 1432-0878
- DOI
- 10.1007/s00441-004-0946-y
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Wallenberg Neuroscience Centre, Lund (0131000110), Neuronal Survival (013212041), Neural Plasticity and Repair (013210080)
- id
- 1caf6c34-441f-4cc3-835d-a9b0a69f7076 (old id 126710)
- date added to LUP
- 2016-04-01 11:51:49
- date last changed
- 2022-04-20 22:58:03
@article{1caf6c34-441f-4cc3-835d-a9b0a69f7076, abstract = {{A major neuropathological feature of Parkinson's disease (PD) is the loss of nigrostriatal dopaminergic neuron. Patients exhibit motor symptoms, including bradykinesia, rigidity, and tremor. Neural grafting has been reported to restore striatial dopaminergic neurotransmission and induce symptomatic relief. The major limitation of cell replacement therapy for PD is the shortage of suitable donor tissue. The present review describes the possible sources of cells, including embryonic stem cells and somatic adult stem cells, both of which potentially could be used in cell therapy for PD, and discusses the advantages and disadvantages of each cell type.}}, author = {{Roybon, Laurent and Christophersen, Nicolaj and Brundin, Patrik and Li, Jia-Yi}}, issn = {{1432-0878}}, keywords = {{Parkinson's disease; Neural grafting; Embryonic stem cells; Somatic adult stem cells}}, language = {{eng}}, number = {{1}}, pages = {{261--273}}, publisher = {{Springer}}, series = {{Cell and Tissue Research}}, title = {{Stem cell therapy for Parkinson's disease: where do we stand?}}, url = {{http://dx.doi.org/10.1007/s00441-004-0946-y}}, doi = {{10.1007/s00441-004-0946-y}}, volume = {{318}}, year = {{2004}}, }