Heart failure in first- and second-generation immigrants aged 18–54 years in Sweden : A national study
(2024) In ESC Heart Failure 11(6). p.3946-3959- Abstract
Purpose: We aimed at analysing the risk of congestive heart failure (CHF) among first- and second-generation immigrants in younger age groups. Methods: All individuals aged 18–54 years, n = 3 973 454 in the first-generation study and n = 3 817 560 in the second-generation study, were included. CHF was defined as at least one registered diagnosis in the National Patient Register between 1 January 1998 and 31 December 2018. Cox regression analysis was used to estimate the relative risk [hazard ratios (HRs) with 99% confidence intervals (CIs)] of incident CHF with adjustments for age, co-morbidities and socio-demographics. Results: In the first-generation study, a total of 85 719 cases of CHF were registered, 54 369 men and 31 350 women,... (More)
Purpose: We aimed at analysing the risk of congestive heart failure (CHF) among first- and second-generation immigrants in younger age groups. Methods: All individuals aged 18–54 years, n = 3 973 454 in the first-generation study and n = 3 817 560 in the second-generation study, were included. CHF was defined as at least one registered diagnosis in the National Patient Register between 1 January 1998 and 31 December 2018. Cox regression analysis was used to estimate the relative risk [hazard ratios (HRs) with 99% confidence intervals (CIs)] of incident CHF with adjustments for age, co-morbidities and socio-demographics. Results: In the first-generation study, a total of 85 719 cases of CHF were registered, 54 369 men and 31 350 women, where fully adjusted models showed HRs for all foreign-born men of 1.12 (99% CI 1.06–1.17) and for women of 0.99 (0.92–1.05). Groups with higher risk included men from Eastern Europe, Central Europe, Africa and Asia and women from Africa and Asia, and a lower risk was found among Latin American women. In the second-generation study, a total of 88 999 cases of CHF were registered, 58 403 men and 30 596 women, where fully adjusted models showed HRs for second-generation men of 1.04 (0.99–1.09) and women of 0.97 (0.90–1.04). Conclusions: The higher risk in some foreign-born groups needs to be paid attention to in clinical practice. The fact that almost all increased risks were attenuated and absent in second-generation immigrants suggests that lifestyle and environmental factors are more important than genetic differences in the risk of CHF.
(Less)
- author
- Wändell, Per LU ; Li, Xinjun LU ; Carlsson, Axel C. ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- congestive heart failure, immigrants, neighbourhood, sex, socio-economic status
- in
- ESC Heart Failure
- volume
- 11
- issue
- 6
- pages
- 3946 - 3959
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:39049515
- scopus:85199527448
- ISSN
- 2055-5822
- DOI
- 10.1002/ehf2.14998
- language
- English
- LU publication?
- yes
- id
- 1ce4ce83-6453-4375-9c05-b78c04a6ff29
- date added to LUP
- 2024-11-13 12:07:12
- date last changed
- 2025-06-12 05:26:34
@article{1ce4ce83-6453-4375-9c05-b78c04a6ff29,
abstract = {{<p>Purpose: We aimed at analysing the risk of congestive heart failure (CHF) among first- and second-generation immigrants in younger age groups. Methods: All individuals aged 18–54 years, n = 3 973 454 in the first-generation study and n = 3 817 560 in the second-generation study, were included. CHF was defined as at least one registered diagnosis in the National Patient Register between 1 January 1998 and 31 December 2018. Cox regression analysis was used to estimate the relative risk [hazard ratios (HRs) with 99% confidence intervals (CIs)] of incident CHF with adjustments for age, co-morbidities and socio-demographics. Results: In the first-generation study, a total of 85 719 cases of CHF were registered, 54 369 men and 31 350 women, where fully adjusted models showed HRs for all foreign-born men of 1.12 (99% CI 1.06–1.17) and for women of 0.99 (0.92–1.05). Groups with higher risk included men from Eastern Europe, Central Europe, Africa and Asia and women from Africa and Asia, and a lower risk was found among Latin American women. In the second-generation study, a total of 88 999 cases of CHF were registered, 58 403 men and 30 596 women, where fully adjusted models showed HRs for second-generation men of 1.04 (0.99–1.09) and women of 0.97 (0.90–1.04). Conclusions: The higher risk in some foreign-born groups needs to be paid attention to in clinical practice. The fact that almost all increased risks were attenuated and absent in second-generation immigrants suggests that lifestyle and environmental factors are more important than genetic differences in the risk of CHF.</p>}},
author = {{Wändell, Per and Li, Xinjun and Carlsson, Axel C. and Sundquist, Jan and Sundquist, Kristina}},
issn = {{2055-5822}},
keywords = {{congestive heart failure; immigrants; neighbourhood; sex; socio-economic status}},
language = {{eng}},
number = {{6}},
pages = {{3946--3959}},
publisher = {{John Wiley & Sons Inc.}},
series = {{ESC Heart Failure}},
title = {{Heart failure in first- and second-generation immigrants aged 18–54 years in Sweden : A national study}},
url = {{http://dx.doi.org/10.1002/ehf2.14998}},
doi = {{10.1002/ehf2.14998}},
volume = {{11}},
year = {{2024}},
}