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Anxiety, depression and quality of life in relation to SARS-CoV-2 antibodies in individuals living with diabetes during the second wave of COVID-19

Lind, Alexander LU ; Yang, Cao ; Hugo, Hesser ; Maria, Hårdstedt ; Stefan, Jansson ; Lernmark, Åke LU orcid ; Martin, Sundqvist ; Staffan, Tevell ; Cheng-ting, Tsai and Jeanette, Wahlberg , et al. (2024) In Diabetes Epidemiology and Management 13.
Abstract

Aims: The objective was to compare anxiety, depression, and quality of life (QoL) in individuals living with type 1 (T1D) and type 2 (T2D) diabetes with matched controls during the second wave of the COVID-19 pandemic. Methods: Via randomization, individuals living with diabetes T1D (n = 203) and T2D (n = 413), were identified during February-July 2021 through health-care registers. Population controls (n = 282) were matched for age, gender, and residential area. Questionnaires included self-assessment of anxiety, depression, QoL, and demographics in relation to SARS-CoV-2 exposure. Blood was collected through home-capillary sampling, and SARS-CoV-2 Nucleocapsid (NCP) and Spike antibodies (SC2_S1) were determined by multiplex Antibody... (More)

Aims: The objective was to compare anxiety, depression, and quality of life (QoL) in individuals living with type 1 (T1D) and type 2 (T2D) diabetes with matched controls during the second wave of the COVID-19 pandemic. Methods: Via randomization, individuals living with diabetes T1D (n = 203) and T2D (n = 413), were identified during February-July 2021 through health-care registers. Population controls (n = 282) were matched for age, gender, and residential area. Questionnaires included self-assessment of anxiety, depression, QoL, and demographics in relation to SARS-CoV-2 exposure. Blood was collected through home-capillary sampling, and SARS-CoV-2 Nucleocapsid (NCP) and Spike antibodies (SC2_S1) were determined by multiplex Antibody Detection by Agglutination-PCR (ADAP) assays. Results: Younger age and health issues were related to anxiety, depression, and QoL, with no differences between the study groups. Female gender was associated with anxiety, while obesity was associated with lower QoL. The SARS‑CoV‑2 NCP seroprevalence was higher in T1D (8.9 %) compared to T2D (3.9 %) and controls (4.0 %), while the SARS‑CoV‑2 SC2_S1 seroprevalence was higher for controls (25.5 %) compared to T1D (16.8 %) and T2D (14.0 %). Conclusions: A higher SARS‑CoV‑2 infection rate in T1D may be explained by younger age and higher employment rate, and the associated increased risk for viral exposure.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anxiety, COVID-19, Depression, Diabetes, Quality of life, SARS-CoV-2, Virus antibodies
in
Diabetes Epidemiology and Management
volume
13
article number
100194
publisher
Elsevier B.V.
external identifiers
  • scopus:85182889973
ISSN
2666-9706
DOI
10.1016/j.deman.2023.100194
language
English
LU publication?
yes
id
1d0cabbc-f06a-4ee9-9c33-413fa82557aa
date added to LUP
2024-02-19 14:31:38
date last changed
2024-02-21 16:07:54
@article{1d0cabbc-f06a-4ee9-9c33-413fa82557aa,
  abstract     = {{<p>Aims: The objective was to compare anxiety, depression, and quality of life (QoL) in individuals living with type 1 (T1D) and type 2 (T2D) diabetes with matched controls during the second wave of the COVID-19 pandemic. Methods: Via randomization, individuals living with diabetes T1D (n = 203) and T2D (n = 413), were identified during February-July 2021 through health-care registers. Population controls (n = 282) were matched for age, gender, and residential area. Questionnaires included self-assessment of anxiety, depression, QoL, and demographics in relation to SARS-CoV-2 exposure. Blood was collected through home-capillary sampling, and SARS-CoV-2 Nucleocapsid (NCP) and Spike antibodies (SC2_S1) were determined by multiplex Antibody Detection by Agglutination-PCR (ADAP) assays. Results: Younger age and health issues were related to anxiety, depression, and QoL, with no differences between the study groups. Female gender was associated with anxiety, while obesity was associated with lower QoL. The SARS‑CoV‑2 NCP seroprevalence was higher in T1D (8.9 %) compared to T2D (3.9 %) and controls (4.0 %), while the SARS‑CoV‑2 SC2_S1 seroprevalence was higher for controls (25.5 %) compared to T1D (16.8 %) and T2D (14.0 %). Conclusions: A higher SARS‑CoV‑2 infection rate in T1D may be explained by younger age and higher employment rate, and the associated increased risk for viral exposure.</p>}},
  author       = {{Lind, Alexander and Yang, Cao and Hugo, Hesser and Maria, Hårdstedt and Stefan, Jansson and Lernmark, Åke and Martin, Sundqvist and Staffan, Tevell and Cheng-ting, Tsai and Jeanette, Wahlberg and Johan, Jendle}},
  issn         = {{2666-9706}},
  keywords     = {{Anxiety; COVID-19; Depression; Diabetes; Quality of life; SARS-CoV-2; Virus antibodies}},
  language     = {{eng}},
  publisher    = {{Elsevier B.V.}},
  series       = {{Diabetes Epidemiology and Management}},
  title        = {{Anxiety, depression and quality of life in relation to SARS-CoV-2 antibodies in individuals living with diabetes during the second wave of COVID-19}},
  url          = {{http://dx.doi.org/10.1016/j.deman.2023.100194}},
  doi          = {{10.1016/j.deman.2023.100194}},
  volume       = {{13}},
  year         = {{2024}},
}