A Monte-Carlo program converting activity distributions to absorbed dose distributions in a radionuclide treatment planning system
(1996) In Acta Oncologica 35(3). p.367-372- Abstract
- In systemic radiation therapy, the absorbed dose distribution must be calculated from the individual activity distribution. A computer code has been developed for the conversion of an arbitrary activity distribution to a 3-D absorbed dose distribution. The activity distribution can be described either analytically or as a voxel based distribution, which comes from a SPECT acquisition. Decay points are sampled according to the activity map, and particles (photons and electrons) from the decay are followed through the tissue until they either escape the patient or drop below a cut off energy. To verify the calculated results, the mathematically defined MIRD phantom and unity density spheres have been included in the code. Also other... (More)
- In systemic radiation therapy, the absorbed dose distribution must be calculated from the individual activity distribution. A computer code has been developed for the conversion of an arbitrary activity distribution to a 3-D absorbed dose distribution. The activity distribution can be described either analytically or as a voxel based distribution, which comes from a SPECT acquisition. Decay points are sampled according to the activity map, and particles (photons and electrons) from the decay are followed through the tissue until they either escape the patient or drop below a cut off energy. To verify the calculated results, the mathematically defined MIRD phantom and unity density spheres have been included in the code. Also other published dosimetry data were used for verification. Absorbed fractions and S-values were calculated. A comparison with simulated data from the code with MIRD data shows good agreement. The S values are within 10-20% of published MIRD S values for most organs. Absorbed fractions for photons and electrons in spheres (masses between 1 g and 200 kg) are within 10-15% of those published. Radial absorbed dose distributions in a necrotic tumor show good agreement with published data. The application of the code in a radionuclide therapy dose planning system, based on quantitative SPECT, is discussed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1110840
- author
- Tagesson, Magnus ; Ljungberg, Michael LU and Strand, Sven-Erik LU
- organization
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Oncologica
- volume
- 35
- issue
- 3
- pages
- 367 - 372
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:8679268
- scopus:0029952594
- ISSN
- 1651-226X
- DOI
- 10.3109/02841869609101653
- language
- English
- LU publication?
- yes
- id
- 1d224037-0ee1-4fbc-96a2-b35e45a49b78 (old id 1110840)
- date added to LUP
- 2016-04-01 17:05:49
- date last changed
- 2022-01-29 00:17:40
@article{1d224037-0ee1-4fbc-96a2-b35e45a49b78,
abstract = {{In systemic radiation therapy, the absorbed dose distribution must be calculated from the individual activity distribution. A computer code has been developed for the conversion of an arbitrary activity distribution to a 3-D absorbed dose distribution. The activity distribution can be described either analytically or as a voxel based distribution, which comes from a SPECT acquisition. Decay points are sampled according to the activity map, and particles (photons and electrons) from the decay are followed through the tissue until they either escape the patient or drop below a cut off energy. To verify the calculated results, the mathematically defined MIRD phantom and unity density spheres have been included in the code. Also other published dosimetry data were used for verification. Absorbed fractions and S-values were calculated. A comparison with simulated data from the code with MIRD data shows good agreement. The S values are within 10-20% of published MIRD S values for most organs. Absorbed fractions for photons and electrons in spheres (masses between 1 g and 200 kg) are within 10-15% of those published. Radial absorbed dose distributions in a necrotic tumor show good agreement with published data. The application of the code in a radionuclide therapy dose planning system, based on quantitative SPECT, is discussed.}},
author = {{Tagesson, Magnus and Ljungberg, Michael and Strand, Sven-Erik}},
issn = {{1651-226X}},
language = {{eng}},
number = {{3}},
pages = {{367--372}},
publisher = {{Taylor & Francis}},
series = {{Acta Oncologica}},
title = {{A Monte-Carlo program converting activity distributions to absorbed dose distributions in a radionuclide treatment planning system}},
url = {{http://dx.doi.org/10.3109/02841869609101653}},
doi = {{10.3109/02841869609101653}},
volume = {{35}},
year = {{1996}},
}