Advanced

Non-Lymphoma Hematological Malignancies in Systemic Lupus Erythematosus

Lu, Mary; Bernatsky, Sasha; Ramsey-Goldman, Rosalind; Petri, Michelle; Manzi, Susan; Urowitz, Murray B.; Gladman, Dafna; Fortin, Paul R.; Ginzler, Ellen M. and Yelin, Edward, et al. (2013) In Oncology 85(4). p.235-240
Abstract
Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n =... (More)
Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation. (C) 2013 S. Karger AG, Basel (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Systemic lupus erythematosus, Malignancy, Cancer
in
Oncology
volume
85
issue
4
pages
235 - 240
publisher
Karger
external identifiers
  • wos:000326934400007
  • scopus:84885036201
ISSN
1423-0232
DOI
10.1159/000350165
language
English
LU publication?
yes
id
1d2d69dd-2ce7-4bba-b4ef-1604476f8231 (old id 4204162)
date added to LUP
2014-01-03 10:46:01
date last changed
2019-02-20 01:51:07
@article{1d2d69dd-2ce7-4bba-b4ef-1604476f8231,
  abstract     = {Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation. (C) 2013 S. Karger AG, Basel},
  author       = {Lu, Mary and Bernatsky, Sasha and Ramsey-Goldman, Rosalind and Petri, Michelle and Manzi, Susan and Urowitz, Murray B. and Gladman, Dafna and Fortin, Paul R. and Ginzler, Ellen M. and Yelin, Edward and Bae, Sang-Cheol and Wallace, Daniel J. and Jacobsen, Soren and Dooley, Mary Anne and Peschken, Christine A. and Alarcon, Graciela S. and Nived, Ola and Gottesman, Lena and Criswell, Lindsey A. and Sturfelt, Gunnar and Dreyer, Lene and Lee, Jennifer L. and Clarke, Ann E.},
  issn         = {1423-0232},
  keyword      = {Systemic lupus erythematosus,Malignancy,Cancer},
  language     = {eng},
  number       = {4},
  pages        = {235--240},
  publisher    = {Karger},
  series       = {Oncology},
  title        = {Non-Lymphoma Hematological Malignancies in Systemic Lupus Erythematosus},
  url          = {http://dx.doi.org/10.1159/000350165},
  volume       = {85},
  year         = {2013},
}