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Implications of stress-induced gene expression for hematopoietic stem cell aging studies

Konturek-Ciesla, Anna LU ; Olofzon, Rasmus LU orcid ; Kharazi, Shabnam LU and Bryder, David LU (2024) In Nature Aging
Abstract

A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have strong implications for the design and interpretation of HSC aging studies.

Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Nature Aging
publisher
Springer
external identifiers
  • pmid:38228925
  • scopus:85182486279
DOI
10.1038/s43587-023-00558-z
language
English
LU publication?
yes
id
1d38bf60-da6a-49ef-b15b-e41f742aa433
date added to LUP
2024-02-16 11:19:36
date last changed
2024-04-17 05:02:26
@article{1d38bf60-da6a-49ef-b15b-e41f742aa433,
  abstract     = {{<p>A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have strong implications for the design and interpretation of HSC aging studies.</p>}},
  author       = {{Konturek-Ciesla, Anna and Olofzon, Rasmus and Kharazi, Shabnam and Bryder, David}},
  language     = {{eng}},
  publisher    = {{Springer}},
  series       = {{Nature Aging}},
  title        = {{Implications of stress-induced gene expression for hematopoietic stem cell aging studies}},
  url          = {{http://dx.doi.org/10.1038/s43587-023-00558-z}},
  doi          = {{10.1038/s43587-023-00558-z}},
  year         = {{2024}},
}