Implications of stress-induced gene expression for hematopoietic stem cell aging studies
(2024) In Nature Aging- Abstract
A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have strong implications for the design and interpretation of HSC aging studies.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1d38bf60-da6a-49ef-b15b-e41f742aa433
- author
- Konturek-Ciesla, Anna LU ; Olofzon, Rasmus LU ; Kharazi, Shabnam LU and Bryder, David LU
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Nature Aging
- publisher
- Springer
- external identifiers
-
- pmid:38228925
- scopus:85182486279
- DOI
- 10.1038/s43587-023-00558-z
- language
- English
- LU publication?
- yes
- id
- 1d38bf60-da6a-49ef-b15b-e41f742aa433
- date added to LUP
- 2024-02-16 11:19:36
- date last changed
- 2024-04-17 05:02:26
@article{1d38bf60-da6a-49ef-b15b-e41f742aa433, abstract = {{<p>A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have strong implications for the design and interpretation of HSC aging studies.</p>}}, author = {{Konturek-Ciesla, Anna and Olofzon, Rasmus and Kharazi, Shabnam and Bryder, David}}, language = {{eng}}, publisher = {{Springer}}, series = {{Nature Aging}}, title = {{Implications of stress-induced gene expression for hematopoietic stem cell aging studies}}, url = {{http://dx.doi.org/10.1038/s43587-023-00558-z}}, doi = {{10.1038/s43587-023-00558-z}}, year = {{2024}}, }