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Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor.

Wackenfors, Angelica LU ; Vikman, Petter LU ; Nilsson, Elisabeth LU ; Edvinsson, Lars LU and Malmsjö, Malin LU (2006) In European Journal of Pharmacology 531(1-3). p.259-263
Abstract
The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT(1) and AT(2) receptor blockers candesartan and PD 123319. Both angiotensin AT(1) and AT(2) receptors were detected on the endothelium by imnitmohistochemistry. (c) 2005... (More)
The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT(1) and AT(2) receptor blockers candesartan and PD 123319. Both angiotensin AT(1) and AT(2) receptors were detected on the endothelium by imnitmohistochemistry. (c) 2005 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebral artery, hyperpolarising factor, angiotensin II, endothelium-derived, vasodilatation
in
European Journal of Pharmacology
volume
531
issue
1-3
pages
259 - 263
publisher
Elsevier
external identifiers
  • wos:000235566200039
  • pmid:16410000
  • scopus:32044470234
ISSN
1879-0712
DOI
10.1016/j.ejphar.2005.11.064
language
English
LU publication?
yes
id
1d4e1ca1-6c49-4fc7-a703-28a780ab705c (old id 150341)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16410000&dopt=Abstract
date added to LUP
2007-07-10 15:30:01
date last changed
2019-07-30 02:03:19
@article{1d4e1ca1-6c49-4fc7-a703-28a780ab705c,
  abstract     = {The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT(1) and AT(2) receptor blockers candesartan and PD 123319. Both angiotensin AT(1) and AT(2) receptors were detected on the endothelium by imnitmohistochemistry. (c) 2005 Elsevier B.V. All rights reserved.},
  author       = {Wackenfors, Angelica and Vikman, Petter and Nilsson, Elisabeth and Edvinsson, Lars and Malmsjö, Malin},
  issn         = {1879-0712},
  keyword      = {cerebral artery,hyperpolarising factor,angiotensin II,endothelium-derived,vasodilatation},
  language     = {eng},
  number       = {1-3},
  pages        = {259--263},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmacology},
  title        = {Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor.},
  url          = {http://dx.doi.org/10.1016/j.ejphar.2005.11.064},
  volume       = {531},
  year         = {2006},
}