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Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging

Andersson, Roger LU ; Evertsson, Maria LU ; Toftevall, Hanna ; Cinthio, Magnus LU orcid ; Fredriksson, Sarah LU and Jansson, Tomas LU (2016) 2016 IEEE International Ultrasonics Symposium, IUS 2016 2016-November.
Abstract

Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to physical size of the embedded superparamagnetic iron oxide nanoparticles. Given the same Fe concentration a weaker response, by a factor of 2, was detected with the larger nanoparticles. However, approximately seven times larger response remains, given the volume ratio between particles, implying a seven times larger response per binding event.... (More)

Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to physical size of the embedded superparamagnetic iron oxide nanoparticles. Given the same Fe concentration a weaker response, by a factor of 2, was detected with the larger nanoparticles. However, approximately seven times larger response remains, given the volume ratio between particles, implying a seven times larger response per binding event. We hypothesize that this can have bearing in molecular imaging.

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author
; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
contrast agents, iron oxide, molecular imaging, nanoparticles, superparamagnetic
host publication
2016 IEEE International Ultrasonics Symposium, IUS 2016
volume
2016-November
article number
7728380
publisher
IEEE Computer Society
conference name
2016 IEEE International Ultrasonics Symposium, IUS 2016
conference location
Tours, France
conference dates
2016-09-18 - 2016-09-21
external identifiers
  • scopus:84996559013
ISBN
9781467398978
DOI
10.1109/ULTSYM.2016.7728380
language
English
LU publication?
yes
id
1dcf905e-9ebb-41c7-b3d4-298a7b87be00
date added to LUP
2016-12-12 10:44:20
date last changed
2024-10-05 08:03:36
@inproceedings{1dcf905e-9ebb-41c7-b3d4-298a7b87be00,
  abstract     = {{<p>Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to physical size of the embedded superparamagnetic iron oxide nanoparticles. Given the same Fe concentration a weaker response, by a factor of 2, was detected with the larger nanoparticles. However, approximately seven times larger response remains, given the volume ratio between particles, implying a seven times larger response per binding event. We hypothesize that this can have bearing in molecular imaging.</p>}},
  author       = {{Andersson, Roger and Evertsson, Maria and Toftevall, Hanna and Cinthio, Magnus and Fredriksson, Sarah and Jansson, Tomas}},
  booktitle    = {{2016 IEEE International Ultrasonics Symposium, IUS 2016}},
  isbn         = {{9781467398978}},
  keywords     = {{contrast agents; iron oxide; molecular imaging; nanoparticles; superparamagnetic}},
  language     = {{eng}},
  month        = {{11}},
  publisher    = {{IEEE Computer Society}},
  title        = {{Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging}},
  url          = {{http://dx.doi.org/10.1109/ULTSYM.2016.7728380}},
  doi          = {{10.1109/ULTSYM.2016.7728380}},
  volume       = {{2016-November}},
  year         = {{2016}},
}