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Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging

Andersson, Roger LU ; Evertsson, Maria LU ; Toftevall, Hanna; Cinthio, Magnus LU ; Fredriksson, Sarah LU and Jansson, Tomas LU (2016) 2016 IEEE International Ultrasonics Symposium, IUS 2016 In 2016 IEEE International Ultrasonics Symposium, IUS 2016 2016-November.
Abstract

Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to physical size of the embedded superparamagnetic iron oxide nanoparticles. Given the same Fe concentration a weaker response, by a factor of 2, was detected with the larger nanoparticles. However, approximately seven times larger response remains, given the volume ratio between particles, implying a seven times larger response per binding event.... (More)

Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to physical size of the embedded superparamagnetic iron oxide nanoparticles. Given the same Fe concentration a weaker response, by a factor of 2, was detected with the larger nanoparticles. However, approximately seven times larger response remains, given the volume ratio between particles, implying a seven times larger response per binding event. We hypothesize that this can have bearing in molecular imaging.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
contrast agents, iron oxide, molecular imaging, nanoparticles, superparamagnetic
in
2016 IEEE International Ultrasonics Symposium, IUS 2016
volume
2016-November
publisher
IEEE Computer Society
conference name
2016 IEEE International Ultrasonics Symposium, IUS 2016
external identifiers
  • scopus:84996559013
ISBN
9781467398978
DOI
10.1109/ULTSYM.2016.7728380
language
English
LU publication?
yes
id
1dcf905e-9ebb-41c7-b3d4-298a7b87be00
date added to LUP
2016-12-12 10:44:20
date last changed
2017-01-01 08:43:02
@inproceedings{1dcf905e-9ebb-41c7-b3d4-298a7b87be00,
  abstract     = {<p>Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In this experimental phantom study we observed a variation in the magnetomotive response in respect to physical size of the embedded superparamagnetic iron oxide nanoparticles. Given the same Fe concentration a weaker response, by a factor of 2, was detected with the larger nanoparticles. However, approximately seven times larger response remains, given the volume ratio between particles, implying a seven times larger response per binding event. We hypothesize that this can have bearing in molecular imaging.</p>},
  author       = {Andersson, Roger and Evertsson, Maria and Toftevall, Hanna and Cinthio, Magnus and Fredriksson, Sarah and Jansson, Tomas},
  booktitle    = {2016 IEEE International Ultrasonics Symposium, IUS 2016},
  isbn         = {9781467398978},
  keyword      = {contrast agents,iron oxide,molecular imaging,nanoparticles,superparamagnetic},
  language     = {eng},
  month        = {11},
  publisher    = {IEEE Computer Society},
  title        = {Effect of nanoparticle size and magnetic field strength on the displacement signal in magnetomotive ultrasound imaging},
  url          = {http://dx.doi.org/10.1109/ULTSYM.2016.7728380},
  volume       = {2016-November},
  year         = {2016},
}