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Prediagnostic serum selenium levels in relation to breast cancer survival and tumor characteristics

Sandsveden, Malte LU ; Nilsson, Emelie LU ; Borgquist, Signe LU ; Rosendahl, Ann H. LU and Manjer, Jonas LU (2020) In International Journal of Cancer 147(9). p.2424-2436
Abstract

Women with lower levels of serum selenium (Se) may have a worse survival in breast cancer than women with higher levels, despite no difference in incidence of the disease. Our study was conducted to test whether Se is associated with the aggressiveness of breast tumors. Both the risk of having a tumor characteristic associated with worse prognosis, as well as the overall and breast cancer-specific mortality, were studied. We identified breast cancer cases and controls within the Malmö Diet and Cancer Study, a population-based cohort with 17 035 women recruited between 1991 and 1996. Inclusion criteria were incident breast cancer. Exclusion criteria were carcinoma in situ and bilateral breast cancer. Controls were selected among breast... (More)

Women with lower levels of serum selenium (Se) may have a worse survival in breast cancer than women with higher levels, despite no difference in incidence of the disease. Our study was conducted to test whether Se is associated with the aggressiveness of breast tumors. Both the risk of having a tumor characteristic associated with worse prognosis, as well as the overall and breast cancer-specific mortality, were studied. We identified breast cancer cases and controls within the Malmö Diet and Cancer Study, a population-based cohort with 17 035 women recruited between 1991 and 1996. Inclusion criteria were incident breast cancer. Exclusion criteria were carcinoma in situ and bilateral breast cancer. Controls were selected among breast cancer-free women both from matching (n = 694) as well as randomization (n = 492). After exclusion, 1066 cases remained and were compared to controls regarding their prediagnostic serum Se levels and subsequent risk of having a certain tumor characteristic or intrinsic subtype. We also followed breast cancer patients regarding overall and breast cancer-specific mortality, comparing different Se quartiles. No association between serum Se quartile and any tumor characteristic or intrinsic subtype was found. Lower overall mortality was found among women in the highest Se quartile compared to the lowest using an adjusted Cox proportional hazards model, hazard ratio 0.63 (95% confidence interval: 0.44-0.89). Similar results were seen for breast cancer-specific mortality, 0.60 (0.37-0.98). The results of our study support that Se is associated with a lower mortality in breast cancer, not related to established prognostic factors.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast cancer, prognostic factors, selenium, survival, tumor
in
International Journal of Cancer
volume
147
issue
9
pages
13 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85086016202
  • pmid:32378183
ISSN
0020-7136
DOI
10.1002/ijc.33031
language
English
LU publication?
yes
id
1de99b4c-25ed-4f55-8d62-8ee4b650603e
date added to LUP
2020-12-28 14:49:38
date last changed
2024-05-31 04:56:40
@article{1de99b4c-25ed-4f55-8d62-8ee4b650603e,
  abstract     = {{<p>Women with lower levels of serum selenium (Se) may have a worse survival in breast cancer than women with higher levels, despite no difference in incidence of the disease. Our study was conducted to test whether Se is associated with the aggressiveness of breast tumors. Both the risk of having a tumor characteristic associated with worse prognosis, as well as the overall and breast cancer-specific mortality, were studied. We identified breast cancer cases and controls within the Malmö Diet and Cancer Study, a population-based cohort with 17 035 women recruited between 1991 and 1996. Inclusion criteria were incident breast cancer. Exclusion criteria were carcinoma in situ and bilateral breast cancer. Controls were selected among breast cancer-free women both from matching (n = 694) as well as randomization (n = 492). After exclusion, 1066 cases remained and were compared to controls regarding their prediagnostic serum Se levels and subsequent risk of having a certain tumor characteristic or intrinsic subtype. We also followed breast cancer patients regarding overall and breast cancer-specific mortality, comparing different Se quartiles. No association between serum Se quartile and any tumor characteristic or intrinsic subtype was found. Lower overall mortality was found among women in the highest Se quartile compared to the lowest using an adjusted Cox proportional hazards model, hazard ratio 0.63 (95% confidence interval: 0.44-0.89). Similar results were seen for breast cancer-specific mortality, 0.60 (0.37-0.98). The results of our study support that Se is associated with a lower mortality in breast cancer, not related to established prognostic factors.</p>}},
  author       = {{Sandsveden, Malte and Nilsson, Emelie and Borgquist, Signe and Rosendahl, Ann H. and Manjer, Jonas}},
  issn         = {{0020-7136}},
  keywords     = {{breast cancer; prognostic factors; selenium; survival; tumor}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{2424--2436}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Prediagnostic serum selenium levels in relation to breast cancer survival and tumor characteristics}},
  url          = {{http://dx.doi.org/10.1002/ijc.33031}},
  doi          = {{10.1002/ijc.33031}},
  volume       = {{147}},
  year         = {{2020}},
}