Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Vascular dynamics during laissez-faire healing in periocular defects assessed with laser speckle contrast imaging

Vennström Berggren, Johanna LU orcid ; Nääv Ottosson, Jens LU ; Tenland, Kajsa LU ; Naumovska, Magdalena LU ; Fontana, Morgana LU ; Merdasa, Aboma LU orcid and Malmsjö, Malin LU orcid (2025) In Orbit
Abstract

Purpose: To evaluate the role of blood perfusion and revascularization during the healing process of periocular defects treated with laissez-faire following tumor excision. Methods: Ten patients with periocular basal cell carcinomas underwent excision, followed by laissez-faire wound management. Blood perfusion was measured using laser speckle contrast imaging postoperatively. Results: Immediately after excision, perfusion increased in the wound edge and the peri-wound tissue, reaching approximately 157% of reference values (p < 0.01), reflecting immediate effects of surgery. At 1 week, perfusion increased further, likely driven by inflammation and angiogenesis (193%, p < 0.001). Perfusion gradually decreased at 6–8 weeks,... (More)

Purpose: To evaluate the role of blood perfusion and revascularization during the healing process of periocular defects treated with laissez-faire following tumor excision. Methods: Ten patients with periocular basal cell carcinomas underwent excision, followed by laissez-faire wound management. Blood perfusion was measured using laser speckle contrast imaging postoperatively. Results: Immediately after excision, perfusion increased in the wound edge and the peri-wound tissue, reaching approximately 157% of reference values (p < 0.01), reflecting immediate effects of surgery. At 1 week, perfusion increased further, likely driven by inflammation and angiogenesis (193%, p < 0.001). Perfusion gradually decreased at 6–8 weeks, aligning with active tissue remodeling, and continued to normalize at 4–5 months (123%, p > 0.05). By 12 months, perfusion returned to baseline levels, reflecting wound maturation (109%, p > 0.05). In cases with directing sutures, perfusion initially decreased to 64% at the wound edge, presumably due to tension-induced hypoperfusion, but returned to baseline after 6–8 weeks. Conclusion: This study highlights the critical role of blood perfusion in the healing of periocular defects treated with laissez-faire. The vascular network is preserved, enabling an immediate increase in perfusion, facilitating revascularization and wound healing. Further studies are needed to evaluate efficacy and long-term outcomes in comparison with reconstructive surgery.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Blood flow, laissez-faire, perfusion monitoring
in
Orbit
publisher
Taylor & Francis
external identifiers
  • scopus:105013780833
  • pmid:40833936
ISSN
0167-6830
DOI
10.1080/01676830.2025.2545402
language
English
LU publication?
yes
id
1de9a353-1ffd-4d5a-9f19-7f7aff56fac9
date added to LUP
2025-11-17 15:47:04
date last changed
2025-11-18 03:00:05
@article{1de9a353-1ffd-4d5a-9f19-7f7aff56fac9,
  abstract     = {{<p>Purpose: To evaluate the role of blood perfusion and revascularization during the healing process of periocular defects treated with laissez-faire following tumor excision. Methods: Ten patients with periocular basal cell carcinomas underwent excision, followed by laissez-faire wound management. Blood perfusion was measured using laser speckle contrast imaging postoperatively. Results: Immediately after excision, perfusion increased in the wound edge and the peri-wound tissue, reaching approximately 157% of reference values (p &lt; 0.01), reflecting immediate effects of surgery. At 1 week, perfusion increased further, likely driven by inflammation and angiogenesis (193%, p &lt; 0.001). Perfusion gradually decreased at 6–8 weeks, aligning with active tissue remodeling, and continued to normalize at 4–5 months (123%, p &gt; 0.05). By 12 months, perfusion returned to baseline levels, reflecting wound maturation (109%, p &gt; 0.05). In cases with directing sutures, perfusion initially decreased to 64% at the wound edge, presumably due to tension-induced hypoperfusion, but returned to baseline after 6–8 weeks. Conclusion: This study highlights the critical role of blood perfusion in the healing of periocular defects treated with laissez-faire. The vascular network is preserved, enabling an immediate increase in perfusion, facilitating revascularization and wound healing. Further studies are needed to evaluate efficacy and long-term outcomes in comparison with reconstructive surgery.</p>}},
  author       = {{Vennström Berggren, Johanna and Nääv Ottosson, Jens and Tenland, Kajsa and Naumovska, Magdalena and Fontana, Morgana and Merdasa, Aboma and Malmsjö, Malin}},
  issn         = {{0167-6830}},
  keywords     = {{Blood flow; laissez-faire; perfusion monitoring}},
  language     = {{eng}},
  publisher    = {{Taylor & Francis}},
  series       = {{Orbit}},
  title        = {{Vascular dynamics during laissez-faire healing in periocular defects assessed with laser speckle contrast imaging}},
  url          = {{http://dx.doi.org/10.1080/01676830.2025.2545402}},
  doi          = {{10.1080/01676830.2025.2545402}},
  year         = {{2025}},
}