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Bacterial interference-is deliberate colonization with Escherichia coli 83972 an alternative treatment for patients with recurrent urinary tract infection?

Sundén, Fredrik LU ; Håkansson, Lars; Ljunggren, Eva and Wullt, Björn LU (2006) 9th International Symposium on Urinary Tract Infection held during the 24th International Congress of Chemotherapy In International Journal of Antimicrobial Agents 28. p.26-29
Abstract
The increasing microbial antibiotic resistance motivates research for non-antibiotic treatment alternatives. In recurrent urinary tract infections (UTIs), 'bacterial interference' has attracted interest as a possible alternative treatment option. The observation that asymptomatic bacteriuria (ABU) protects against recurrent UTI has prompted clinical trials with deliberate colonization of the human urinary tract as an alternative approach in patients with recurrent UTI. The strain used for colonization, the ABU isolate Escherichia coli 83972, has been shown to cause symptom-free colonizations for long periods of time. Patients on long-term colonization report a subjective benefit, and UTI treatments are rare in colonized patients. This... (More)
The increasing microbial antibiotic resistance motivates research for non-antibiotic treatment alternatives. In recurrent urinary tract infections (UTIs), 'bacterial interference' has attracted interest as a possible alternative treatment option. The observation that asymptomatic bacteriuria (ABU) protects against recurrent UTI has prompted clinical trials with deliberate colonization of the human urinary tract as an alternative approach in patients with recurrent UTI. The strain used for colonization, the ABU isolate Escherichia coli 83972, has been shown to cause symptom-free colonizations for long periods of time. Patients on long-term colonization report a subjective benefit, and UTI treatments are rare in colonized patients. This report presents an update on open long-term E. coli 83972 colonization trials and describes the design of an ongoing randomized trial. (c) 2006 Published by Elsevier B.V. and the International Society of Chemotherapy. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Escherichia, recurrent urinary tract infections, bacterial interference, coli 83972, asymptomatic bacteriuria
in
International Journal of Antimicrobial Agents
volume
28
pages
26 - 29
publisher
Elsevier
conference name
9th International Symposium on Urinary Tract Infection held during the 24th International Congress of Chemotherapy
conference location
4-6 June 2005
external identifiers
  • wos:000240406100008
  • scopus:33746770968
ISSN
1872-7913
DOI
10.1016/j.ijantimicag.2006.05.007
language
English
LU publication?
yes
id
1df5db19-b2ec-4238-ba3f-f11dffbf3721 (old id 158915)
date added to LUP
2007-07-24 10:45:53
date last changed
2019-02-20 03:42:59
@article{1df5db19-b2ec-4238-ba3f-f11dffbf3721,
  abstract     = {The increasing microbial antibiotic resistance motivates research for non-antibiotic treatment alternatives. In recurrent urinary tract infections (UTIs), 'bacterial interference' has attracted interest as a possible alternative treatment option. The observation that asymptomatic bacteriuria (ABU) protects against recurrent UTI has prompted clinical trials with deliberate colonization of the human urinary tract as an alternative approach in patients with recurrent UTI. The strain used for colonization, the ABU isolate Escherichia coli 83972, has been shown to cause symptom-free colonizations for long periods of time. Patients on long-term colonization report a subjective benefit, and UTI treatments are rare in colonized patients. This report presents an update on open long-term E. coli 83972 colonization trials and describes the design of an ongoing randomized trial. (c) 2006 Published by Elsevier B.V. and the International Society of Chemotherapy.},
  author       = {Sundén, Fredrik and Håkansson, Lars and Ljunggren, Eva and Wullt, Björn},
  issn         = {1872-7913},
  keyword      = {Escherichia,recurrent urinary tract infections,bacterial interference,coli 83972,asymptomatic bacteriuria},
  language     = {eng},
  location     = {4-6 June 2005},
  pages        = {26--29},
  publisher    = {Elsevier},
  series       = {International Journal of Antimicrobial Agents},
  title        = {Bacterial interference-is deliberate colonization with Escherichia coli 83972 an alternative treatment for patients with recurrent urinary tract infection?},
  url          = {http://dx.doi.org/10.1016/j.ijantimicag.2006.05.007},
  volume       = {28},
  year         = {2006},
}