Basal Metabolic Requirements, Biomarkers of Cardiometabolic Health, and Anthropometric Measures of Obesity in Women and Men With Restricted Growth Conditions
Merrell, Lucy H. ; Smith, Harry A. ; Carroll, Harriet A. LU
; Chen, Yung Chih
; Thompson, Dylan
; Gonzalez, Javier T.
; Atkinson, Greg
and Betts, James A.
(2025)
In American Journal of Medical Genetics, Part A
- Abstract
Population-specific thresholds have not been defined for the levels of adiposity and systemic biomarkers that predict chronic health risks in people with restricted growth conditions. Here, anthropometric measures of adiposity, basal metabolic requirements, and fasted blood samples were obtained from adults with restricted growth (age 41 ± 14 years, height 1.30 ± 0.10 m, body mass 60.5 ± 18.3 kg, female: male n = 24:13, achondroplasia n = 26; mean ± SD). Basal metabolic rate was 6529 ± 1703 kJ·d−1 and total mass-normalized energy requirements were higher for females versus males. Plasma concentrations of glucose (5.55 ± 0.73 mmol·L−1), insulin (36.4 ± 19.9 pmol·L−1) and lipids (triacylglycerol 0.84 ±... (More)
Population-specific thresholds have not been defined for the levels of adiposity and systemic biomarkers that predict chronic health risks in people with restricted growth conditions. Here, anthropometric measures of adiposity, basal metabolic requirements, and fasted blood samples were obtained from adults with restricted growth (age 41 ± 14 years, height 1.30 ± 0.10 m, body mass 60.5 ± 18.3 kg, female: male n = 24:13, achondroplasia n = 26; mean ± SD). Basal metabolic rate was 6529 ± 1703 kJ·d−1 and total mass-normalized energy requirements were higher for females versus males. Plasma concentrations of glucose (5.55 ± 0.73 mmol·L−1), insulin (36.4 ± 19.9 pmol·L−1) and lipids (triacylglycerol 0.84 ± 0.37 mmol·L−1; total cholesterol 4.54 ± 0.85 mmol·L−1; high-density lipoprotein cholesterol 1.41 ± 0.31 mmol·L−1; low-density lipoprotein cholesterol 2.73 ± 0.69 mmol·L−1) were mostly within healthy clinical reference ranges. Sagittal abdominal diameter was positively correlated with plasma glucose and leptin concentrations (r = 0.85; 95% CI: 0.61, 0.95; p < 0.0001, and r = 0.85; 95% CI: 0.61, 0.95; p < 0.0001, respectively). Mean ± SD body mass index (BMI) was 36.1 ± 11.0 kg·m−2. However, we found that body mass scaled to height by the power of 1.4 (95% CI: 0.2, 2.6) rather than 2 associated with conventional BMI. Conventional biomarkers of cardiometabolic health are not substantially elevated in these individuals with restricted growth despite the classification of obesity using height-dependent references (e.g., traditional BMI).
(Less)
- author
- Merrell, Lucy H.
; Smith, Harry A.
; Carroll, Harriet A.
LU
; Chen, Yung Chih
; Thompson, Dylan
; Gonzalez, Javier T.
; Atkinson, Greg
and Betts, James A.
- organization
- publishing date
- 2025
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- achondroplasia, cardiometabolic health, metabolic requirements, skeletal dysplasia
- in
- American Journal of Medical Genetics, Part A
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:40935802
- scopus:105015493397
- ISSN
- 1552-4825
- DOI
- 10.1002/ajmg.a.64235
- language
- English
- LU publication?
- yes
- id
- 1e305066-062c-4535-8b48-3bc12cc8e7e7
- date added to LUP
- 2025-11-13 14:20:44
- date last changed
- 2025-12-11 17:14:41
@article{1e305066-062c-4535-8b48-3bc12cc8e7e7,
abstract = {{<p>Population-specific thresholds have not been defined for the levels of adiposity and systemic biomarkers that predict chronic health risks in people with restricted growth conditions. Here, anthropometric measures of adiposity, basal metabolic requirements, and fasted blood samples were obtained from adults with restricted growth (age 41 ± 14 years, height 1.30 ± 0.10 m, body mass 60.5 ± 18.3 kg, female: male n = 24:13, achondroplasia n = 26; mean ± SD). Basal metabolic rate was 6529 ± 1703 kJ·d<sup>−1</sup> and total mass-normalized energy requirements were higher for females versus males. Plasma concentrations of glucose (5.55 ± 0.73 mmol·L<sup>−1</sup>), insulin (36.4 ± 19.9 pmol·L<sup>−1</sup>) and lipids (triacylglycerol 0.84 ± 0.37 mmol·L<sup>−1</sup>; total cholesterol 4.54 ± 0.85 mmol·L<sup>−1</sup>; high-density lipoprotein cholesterol 1.41 ± 0.31 mmol·L<sup>−1</sup>; low-density lipoprotein cholesterol 2.73 ± 0.69 mmol·L<sup>−1</sup>) were mostly within healthy clinical reference ranges. Sagittal abdominal diameter was positively correlated with plasma glucose and leptin concentrations (r = 0.85; 95% CI: 0.61, 0.95; p < 0.0001, and r = 0.85; 95% CI: 0.61, 0.95; p < 0.0001, respectively). Mean ± SD body mass index (BMI) was 36.1 ± 11.0 kg·m<sup>−2</sup>. However, we found that body mass scaled to height by the power of 1.4 (95% CI: 0.2, 2.6) rather than 2 associated with conventional BMI. Conventional biomarkers of cardiometabolic health are not substantially elevated in these individuals with restricted growth despite the classification of obesity using height-dependent references (e.g., traditional BMI).</p>}},
author = {{Merrell, Lucy H. and Smith, Harry A. and Carroll, Harriet A. and Chen, Yung Chih and Thompson, Dylan and Gonzalez, Javier T. and Atkinson, Greg and Betts, James A.}},
issn = {{1552-4825}},
keywords = {{achondroplasia; cardiometabolic health; metabolic requirements; skeletal dysplasia}},
language = {{eng}},
publisher = {{John Wiley & Sons Inc.}},
series = {{American Journal of Medical Genetics, Part A}},
title = {{Basal Metabolic Requirements, Biomarkers of Cardiometabolic Health, and Anthropometric Measures of Obesity in Women and Men With Restricted Growth Conditions}},
url = {{http://dx.doi.org/10.1002/ajmg.a.64235}},
doi = {{10.1002/ajmg.a.64235}},
year = {{2025}},
}