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Extracellular vesicle impact on immunity following blood transfusion

Marcoux, Genevieve LU ; Hasse, Stephan LU orcid ; Olsson, Martin L. LU orcid ; Egesten, Arne LU and Duchez, Anne Claire (2025) In Current Opinion in Immunology 95.
Abstract

Purpose of the Review: Recent insights into extracellular vesicles (EVs) derived from platelet (PC) and red blood cell concentrates (RBC), which form during blood product processing and storage. Recent Findings: EVs impact transfusion outcomes by modulating immune and inflammatory responses. Acting as lipid mediators and expressing adhesion molecules, EVs contribute to immune signaling via cytokines, DAMPs, and antigen-presenting molecules. In RBC, EVs accumulate during storage and are linked to endothelial cell (EC) activation, increased thrombotic risk, and tissue inflammation — especially under existing inflammatory conditions. While their effect on circulating immune cells is limited, they strongly activate tissue-resident immune... (More)

Purpose of the Review: Recent insights into extracellular vesicles (EVs) derived from platelet (PC) and red blood cell concentrates (RBC), which form during blood product processing and storage. Recent Findings: EVs impact transfusion outcomes by modulating immune and inflammatory responses. Acting as lipid mediators and expressing adhesion molecules, EVs contribute to immune signaling via cytokines, DAMPs, and antigen-presenting molecules. In RBC, EVs accumulate during storage and are linked to endothelial cell (EC) activation, increased thrombotic risk, and tissue inflammation — especially under existing inflammatory conditions. While their effect on circulating immune cells is limited, they strongly activate tissue-resident immune and EC. In PCs, platelet-derived EVs and other cell-specific EVs also emerge. Certain EV subtypes express CD27, CD70, CD39, and HLA antigens, altering T-cell, B-cell, and monocyte activity. These immunomodulatory effects may contribute to transfusion-related immunomodulation and alloimmunization. EVs in stored blood products influence immune responses highlighting the need for monitoring.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Immunology
volume
95
article number
102603
publisher
Elsevier
external identifiers
  • pmid:40609228
  • scopus:105009515959
ISSN
0952-7915
DOI
10.1016/j.coi.2025.102603
language
English
LU publication?
yes
id
1e31d7c8-566f-42f3-ac2f-8d6524a641d0
date added to LUP
2025-11-05 09:55:49
date last changed
2025-11-06 02:55:05
@article{1e31d7c8-566f-42f3-ac2f-8d6524a641d0,
  abstract     = {{<p>Purpose of the Review: Recent insights into extracellular vesicles (EVs) derived from platelet (PC) and red blood cell concentrates (RBC), which form during blood product processing and storage. Recent Findings: EVs impact transfusion outcomes by modulating immune and inflammatory responses. Acting as lipid mediators and expressing adhesion molecules, EVs contribute to immune signaling via cytokines, DAMPs, and antigen-presenting molecules. In RBC, EVs accumulate during storage and are linked to endothelial cell (EC) activation, increased thrombotic risk, and tissue inflammation — especially under existing inflammatory conditions. While their effect on circulating immune cells is limited, they strongly activate tissue-resident immune and EC. In PCs, platelet-derived EVs and other cell-specific EVs also emerge. Certain EV subtypes express CD27, CD70, CD39, and HLA antigens, altering T-cell, B-cell, and monocyte activity. These immunomodulatory effects may contribute to transfusion-related immunomodulation and alloimmunization. EVs in stored blood products influence immune responses highlighting the need for monitoring.</p>}},
  author       = {{Marcoux, Genevieve and Hasse, Stephan and Olsson, Martin L. and Egesten, Arne and Duchez, Anne Claire}},
  issn         = {{0952-7915}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Current Opinion in Immunology}},
  title        = {{Extracellular vesicle impact on immunity following blood transfusion}},
  url          = {{http://dx.doi.org/10.1016/j.coi.2025.102603}},
  doi          = {{10.1016/j.coi.2025.102603}},
  volume       = {{95}},
  year         = {{2025}},
}