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Postoperative studies on parathyroid hormone secretion in patients operated on for primary hyperparathyroidism

Bergenfelz, A LU ; Nordén, N E LU and Ahrén, B LU (1993) In Clinica Chimica Acta 219(1-2). p.67-77
Abstract

The secretion of intact parathyroid hormone (PTH) was investigated in 11 patients operated on for parathyroid adenoma at 1 year after surgery and compared with that of seven healthy individuals and five patients operated on because of clinical and biochemical signs of primary hyperparathyroidism with equivocal diagnosis after surgery. The investigation was performed by infusing Na2EDTA and CaCl2 at constant rates. No significant difference was found in the suppressibility of PTH secretion by calcium. The set point (the calcium concentration required for half-maximal inhibition of PTH secretion) was slightly lower in patients (1.20 +/- 0.02 mmol/l) compared with healthy subjects (1.23 +/- 0.03 mmol/l; P < 0.05). During the... (More)

The secretion of intact parathyroid hormone (PTH) was investigated in 11 patients operated on for parathyroid adenoma at 1 year after surgery and compared with that of seven healthy individuals and five patients operated on because of clinical and biochemical signs of primary hyperparathyroidism with equivocal diagnosis after surgery. The investigation was performed by infusing Na2EDTA and CaCl2 at constant rates. No significant difference was found in the suppressibility of PTH secretion by calcium. The set point (the calcium concentration required for half-maximal inhibition of PTH secretion) was slightly lower in patients (1.20 +/- 0.02 mmol/l) compared with healthy subjects (1.23 +/- 0.03 mmol/l; P < 0.05). During the hypocalcemic EDTA infusion, the secretion of PTH was higher in controls compared with patients (P < 0.01). By comparing the data from the infusion tests in patients operated on for parathyroid adenomas with the data obtained from the patients with equivocal diagnosis after parathyroid surgery, a good probability for the diagnosis could be obtained.

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published
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keywords
Adenoma, Aged, Aged, 80 and over, Calcifediol, Calcium Chloride, Edetic Acid, Female, Humans, Hyperparathyroidism, Male, Middle Aged, Parathyroid Hormone, Parathyroid Neoplasms, Postoperative Period, Vitamin D
in
Clinica Chimica Acta
volume
219
issue
1-2
pages
11 pages
publisher
Elsevier
external identifiers
  • scopus:0027423723
ISSN
0009-8981
DOI
10.1016/0009-8981(93)90198-D
language
English
LU publication?
yes
id
1e45a436-a4ce-4d26-bdf0-a54cdd41a4e1
date added to LUP
2017-05-10 17:45:12
date last changed
2017-05-14 04:51:13
@article{1e45a436-a4ce-4d26-bdf0-a54cdd41a4e1,
  abstract     = {<p>The secretion of intact parathyroid hormone (PTH) was investigated in 11 patients operated on for parathyroid adenoma at 1 year after surgery and compared with that of seven healthy individuals and five patients operated on because of clinical and biochemical signs of primary hyperparathyroidism with equivocal diagnosis after surgery. The investigation was performed by infusing Na2EDTA and CaCl2 at constant rates. No significant difference was found in the suppressibility of PTH secretion by calcium. The set point (the calcium concentration required for half-maximal inhibition of PTH secretion) was slightly lower in patients (1.20 +/- 0.02 mmol/l) compared with healthy subjects (1.23 +/- 0.03 mmol/l; P &lt; 0.05). During the hypocalcemic EDTA infusion, the secretion of PTH was higher in controls compared with patients (P &lt; 0.01). By comparing the data from the infusion tests in patients operated on for parathyroid adenomas with the data obtained from the patients with equivocal diagnosis after parathyroid surgery, a good probability for the diagnosis could be obtained.</p>},
  author       = {Bergenfelz, A and Nordén, N E and Ahrén, B},
  issn         = {0009-8981},
  keyword      = {Adenoma,Aged,Aged, 80 and over,Calcifediol,Calcium Chloride,Edetic Acid,Female,Humans,Hyperparathyroidism,Male,Middle Aged,Parathyroid Hormone,Parathyroid Neoplasms,Postoperative Period,Vitamin D},
  language     = {eng},
  month        = {10},
  number       = {1-2},
  pages        = {67--77},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {Postoperative studies on parathyroid hormone secretion in patients operated on for primary hyperparathyroidism},
  url          = {http://dx.doi.org/10.1016/0009-8981(93)90198-D},
  volume       = {219},
  year         = {1993},
}